Antioxidative and Hepatoprotective Effects of Lythrum salicaria
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Several parts of Lythrum salicaria were used for this study. Scavenging activities on radicals, inhibitory activity on linoleic acid peroxidation and total phenol contents of extracts from root, flower, and aerial part were evaluated. Flower and root selected from in vitro assay were subjected to in vivo assay on CCL4-induced liver injury rat model for two weeks. Carbon tetrachloride intoxication on rats produced large amounts of hepatic lipid peroxidation product, thiobarbituric acid reactive substance (TBARS) compared with normal rats. Treatment with root extract of L. salicaria (LSR) showed effective inhibitory activity on lipid peroxidation product. Administration with LSR extract significantly alleviated CCL4- induced increase in GPT activity which were more effective than silymarin. The results of this study suggest that root and flower of L. salicaria have antioxidant and liver protecting activities, and root part is the most effective candidate to develop a new functional material.
Abstract
Several parts of Lythrum salicaria were used for this study. Scavenging activities on radicals, inhibitory activity on linoleic acid peroxidation and total phenol contents of extracts from root, flower, and aerial part were evaluated. Flower and root selected from in vitro assay were subjected to in vivo assay on CCL4-induced liver injury rat model for two weeks. Carbon tetrachloride intoxication on rats produced large amounts of hepatic lipid peroxidation product, thiobarbituric acid reactive substance (TBARS) compared with normal rats. Treatment with root extract of L. salicaria (LSR) showed effective inhibitory activity on lipid peroxidation product. Administration with LSR extract significantly alleviated CCL4- induced increase in GPT activity which were more effective than silymarin. The results of this study suggest that root and flower of L. salicaria have antioxidant and liver protecting activities, and root part is the most effective candidate to develop a new functional material.
참고문헌 (39)
- Achliya GS, "Evaluation of hepatoprotective effect of Amalkadi Ghita against carbon tetrachloride-induced hepatic damage in rats", Journal of Ethnophamacology, 90, pp.229~232 (2004)
- Altanlar N, "Antilisterial activity of some plants used in folk medicine", Pharmaceutical Biology, 44, pp.91~94 (2006)
- Ahmed A, "Evaluation of the efficacy of Lawsonia alba in the alleviation of carbon tetrachloride-induced oxidative stress", Journal of Ethnopharmacology, 69, pp.157~164 (2000)
- Becker H, "Bioactivity guided isolation of antimicrobial compounds from Lythrum salicaria", Fitoterapia, 7, pp.580~584 (2005)
- Botsoglou NA, "Rapid, sensitive and specific thiobarbituric acid methods for measuring lipid peroxidation in animal tissues, food and foodstuffs", Journal of Agricultural and Food Chemistry, 42, pp.1931~1937 (1994)
- Bradford MM, "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding", Analytical Biochemistry, 72, pp.248~254 (1976)
- Bruck R, "Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers", Journal of Hepatology, 35, pp.457~464 (2001)
- Chen LH, "Effects of acute alcohol-intoxication on liver antioxidant defense systems in rats", Biochemical Archives, 8, pp.95~100 (1992)
- Chen LH, "Large doses of ethanol and activities of liver-enzymes which detoxify reactive oxygen species : effects of antioxidants", Biochemical Archives, 12, pp.95~104 (1996)
- Coban T, "Antioxidant activities of plants used in traditional medicine in Turkey", Pharmaceutical Biology, 41, pp.608~613 (2003)
- Ellman GL, "Tissue sulfhydryl group", Archives of Biochemistry and Biophysics, 82, pp.70~72 (1959)
- Flohe' L, "Superoxide dismutase assays. In Methods in Enzymology Vol. 105", pp.93~105 (1984), Academic Press
- Flohe' L, "Determination of glutathione peroxidase. In Handbook of Free Radicals and Antioxidants in Biomedicine, vol III", pp.283~284 (1989), CRC Press Inc
- Frei B, "Natural antioxidants in human health and disease", pp.25~55 (1994), Academic press
- Ha KT, "Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity", Journal of Ethnopharma-cology, 96, pp.529~535 (2005)
- Halliwell B, "Free radicals, antioxidants, and humans disease: where are we now?", Journal of Laboratory and Clinical Medicine, 119, pp.598~620 (1992)
- Honeckman A DVM, "Current concepts in the treatment of canine chronic hepatitis", Clinical Techniques in Small Animal Practice, 18, pp.239~244 (2003)
- Jeong HG, "Hepatoprotective effects of 18â-glycyrrhetinic acid on carbon tetrachloride-induced liver injury:inhibition of cytochrome P4502E1 expression", Pharmacological Research, 46, pp.221~227 (2002)
- Joy KL, "Inhibition by Picrorrhiza kurroa extract of oxygen free radical reactions and hepatic fibrosis in rats", Journal of Clinical Biochemistry and Nutrition, 27, pp.9~17 (1999)
- Jung BS, "Hyangyak-Seangyak Great Encyclopedia", pp.730~731 (1990), Young-Lim Publishing Co
- Kang HC, "Curcumin inhibits collagen synthesis and hepatic stellate cell activation in-vivo and in-vitro", Journal of Pharmacy and Pharmacology, 54, pp.119~126 (2002)
- Kim NM, "Effect of solvents and some extraction conditions on antioxidant activity in cinnamon extracts", Korean Journal of Food Science and Technology, 25, pp.204~209 (1993)
- Lamela M, "Effects of Lythrum salicaria in normoglycemic rats", Journal of Ethnopharmacology, 14, pp.83~91 (1985)
- Lamela M, "Effects of Lythrum salicaria extracts on hyperglycemic rats and mice", Journal of Ethnopharmacology, 15, pp.153~160 (1986)
- Lee KJ, "Protective effect of Platycodi radix on carbon tetrachlorice-induced hepatotoxicity", Food and Chemical Toxicology, 40, pp.517~525 (2002)
- 이승은, "박하의 in vitro 항산화활성", 한국약용작물학회지, 13(6), pp.255~260 (2005), 한국약용작물학회
- MacDonald-Wicks LK, "Vitamin E supplementation in the mitigation of carbon tetrachloride induced oxidative stress in rats", Journal of Nutritional Biochemistry, 14, pp.211~218 (2003)
- Meister A, "Glutathione metabolism and its selective modification", Journal of Biological Chemistry, 263, pp.17205~17208 (1988)
- Nishikimi M, "The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen", Biochemical and Biophysical Research Communications, 46, pp.849~854 (1972)
- Paola V, "Dietary antioxidant compounds and liver disease", Critical Reviews in Food Science and Nutrition, 44, pp.575~586 (2004)
- Rauha JP, "Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds", International Journal of Food Microbiology, 56, pp.3~12 (2000)
- Rodeiro I, "Potential hepatoprotective effects of new Cuban natural products in rat heatocytes culture", Toxicology In Vitro, 22, pp.1242~1249 (2008)
- Singh N, "Protective effect of potato peel extract against carbon tetrachloride-induced liver injury in rats", Environmetal Toxicology and Pharmacology, 26, pp.241~246 (2008)
- Takao TF, "A simple screening method for antioxidants and isolation of several antioxidants produced by marine bacteria from fish and shell fish", Bioscience Biotechnology and Biochemistry, 58, pp.1780~1783 (1994)
- Tasaduq SA, "Hepatocurative and antioxidant profile of HP-1, a polyherbal phyomedicine", Human and Experimental Toxicology, 22, pp.639~645 (2003)
- Tunalier Z, "Antioxidant, anti-inflammatory, antinociceptive activities and composition of Lythrum salicaria L. extracts", Journal of Ethnopharmacology, 110, pp.539~547 (2007)
- Wallig MA, "Induction of rat pancreativ glutathione-S-transferase and quinine reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts", Food and Chemical Toxicology, 35, pp.365~373 (1998)
- Wong CK, "Protective effects of seaweeds against liver injury caused by carbon tetrachloride in rats", Chemosphere, 41, pp.173~176 (2000)
- Yang KS, "Effect of Arctii fructus on low density lipoprotein oxidation", Korean Journal of Pharmacognocy, 28, pp.275~279 (1997)