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복합 고온 전처리 더덕 추출물의 미백 활성 탐색

Screening of Skin Whitening Activity of Codonopsis lanceolata Extract by Complex Steaming Process

김지웅|이현용|권희석|임혜원|김지선
한국약용작물학회|2013.02|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제21권 제1호|pp. 54-60

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키워드

Antioxidative activityCodonopsis lanceolataHigh Pressure ProcessStepwise Hot Steaming ProcessSkin Whitening

초록

According to previous reports, antioxidant activities of Codonopsis lanceolata could be increased by a steaming process. This study was performed to improve its antioxidant activity and skin whitening activities of C. lanceolata by high pressure and stepwise steaming complex process. The complex processed C. lanceolata showed highest free radical scavenging acitivity as 45.21%, and for phenol and flavonoid contents, complex processed C. lanceolata contained higher than those from conventional extraction process or steaming process alone. The Cytotoxicity of all C. lanceolata extracts also showed low cytotoxicity against human fibroblast cell (CCD-986sk) as 4.49 ~ 10.40%. In whitening activity, high inhibition of tyrosinase activity was estimated as 25.08% by adding the extracts from complex process. We found that whitening and antioxidant activity of complex processed C. lancolata extract was higher than those obtained from conventional extraction and a steaming process because various kinds of antioxidant compounds could be easily released by combined process, compared to one of each process.

Abstract

According to previous reports, antioxidant activities of Codonopsis lanceolata could be increased by a steaming process. This study was performed to improve its antioxidant activity and skin whitening activities of C. lanceolata by high pressure and stepwise steaming complex process. The complex processed C. lanceolata showed highest free radical scavenging acitivity as 45.21%, and for phenol and flavonoid contents, complex processed C. lanceolata contained higher than those from conventional extraction process or steaming process alone. The Cytotoxicity of all C. lanceolata extracts also showed low cytotoxicity against human fibroblast cell (CCD-986sk) as 4.49 ~ 10.40%. In whitening activity, high inhibition of tyrosinase activity was estimated as 25.08% by adding the extracts from complex process. We found that whitening and antioxidant activity of complex processed C. lancolata extract was higher than those obtained from conventional extraction and a steaming process because various kinds of antioxidant compounds could be easily released by combined process, compared to one of each process.

참고문헌 (34)

  1. 안봉전, "추출조건에 따른 울금의 항산화 및 미백 효과", 한국약용작물학회지, 14(3), pp.168~172 (2006), 한국약용작물학회
  2. Bennett PB, "High pressure biology and medicine", pp.1~428 (1998), University of Rochester Press
  3. Bernadette EK, "Protective effect against sunburn of combined systemic ascorbic acid and a-tocopherol", Experimental Dermatology, 38, pp.45~48 (1998)
  4. Cha JY, "Effects of hesperetin and naringenin on lipid concentration in orotic acid treated mice", Korean Journal of Life Science, 9, pp.389~394 (1999)
  5. 조영락, "산지별 더덕 추출물의 폐암 및 난소암에 대한 항암 효능", 산업식품공학, 15(1), pp.1~5 (2011), 한국산업식품공학회
  6. Dietz BM, "Xanthohumol isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase", Chemical Research in Toxicology, 18, pp.1296~1305 (2005)
  7. Fang YZ, "Free radicals, antioxidants, and nutrition", Nutrition, 18, pp.872~879 (2002)
  8. Gutfinger T., "Polyphenols in olive oils", Journal of the American Oil Chemists’ Society, 58, pp.966~967 (1981)
  9. 하상근, "Effect of the BuOH Soluble Fraction of Cinnamomum camphora on Melanin Biosynthesis", 한국약용작물학회지, 17(4), pp.293~300 (2009), 한국약용작물학회
  10. Han EG, "Effect of Codonopsis lanceolata water extract on the levels of lipid in rats fed high fat diet", Korean Journal of Society of Food Science and Nutrition, 27, pp.940~944 (1998)
  11. Ishihara K, "Pigment production in murine melanoma cell is regulated by tyrosinase, tyrosinase-related protein 1 (TRP1), DOPAchrome tautomerase (TRP2) and a melanogenic inhibitor", Journal of Investigative Dermatology, 2, pp.126~131 (1993)
  12. 정명훈, "고로쇠 및 우산고로쇠나무의 부위별 미백 및 피부면역 활성", 한국임학회지, 99(4), pp.470~478 (2010), 한국임학회
  13. 지선옥, "상백피 추출물의 항산화 활성 및 미백효과", 한국자원식물학회지, 22(2), pp.145~151 (2009), 한국자원식물학회
  14. 정래승, "증숙 및 발효 더덕의 이화학적 특성 및 생리활성 변화", 한국식품과학회지, 44(1), pp.135~139 (2012), 한국식품과학회
  15. 정성제, "약용 식물 추출물의 항산화 활성 검색", Journal of the Korean Society for Applied Biological Chemistry, 47(1), pp.135~140 (2004), 한국응용생명화학회
  16. Kang KS, "Increase in the free radical scavenging activity of ginseng by heatprocessing", Biological and Pharmaceutical Bulletin, 29, pp.750~754 (2006)
  17. 김지선, "고로쇠 수액 나노입자의 항산화 활성 및 미백 효과의 증진", 한국약용작물학회지, 19(3), pp.191~197 (2011), 한국약용작물학회
  18. 김승섭, "산지별 더덕의 초고압 추출을 통한 항산화 활성 비교", 한국약용작물학회지, 18(4), pp.248~254 (2010), 한국약용작물학회
  19. Kim YJ, "Antimelanogenic and antioxidant properties of gallic acid", Biological and Pharmaceutical Bulletin, 30, pp.1052~1055 (2007)
  20. Komiyama K, "New inhibitors of melanogenesis, OH-3084 K1 and K2", The Journal of Antibiotics, 46, pp.1520~1525 (1993)
  21. 이계원, "가래나무 추출물의 미백효과", KSBB Journal, 25(1), pp.18~24 (2010), 한국생물공학회
  22. Lee JH, "Nutraceuticals, aging, and food oxidation, In Handbook of Functional Lipids", pp.325~350 (2006), Taylor & Francis Group LLC CRC Press
  23. Lerner AB, "Biochemistry of melanin formation", Physiological Reviews, 30, pp.91~126 (1950)
  24. Moreno MI, "Comparison of the free radical-scavenging activity of propolis from several regions of Argentina", Journal of Ethnopharmacology, 71, pp.109~114 (2000)
  25. Mosmann T, "Rapid colorimetric assay for cellular growth and survival : Application to proliferation and cytotoxicity assays", Journal of Immunological Methods, 65, pp.55~63 (1983)
  26. 남기열, "홍삼과 백삼의 비교 고찰", Journal of Ginseng Research, 29(1), pp.1~18 (2005), 고려인삼학회
  27. 박성진, "초고압 추출 처리에 의한 더덕 및 발효더덕의 항산화 증진", 한국식품영양과학회지, 39(12), pp.1898~1902 (2010), 한국식품영양과학회
  28. Park SN, "Skin aging and antioxidants", Journal of the Society of Cosmetic Scientists of Korea, 23, pp.75~132 (1997)
  29. 류혜숙, "더덕 추출물이 마우스 면역세포 증식에 미치는 영향", 한국식품영양학회지, 21(3), pp.263~268 (2008), 한국식품영양학회
  30. 서은종, "짝자래나무 추출물의 항산화 및 미백 효과", 한국식품과학회지, 42(6), pp.750~754 (2010), 한국식품과학회
  31. Sawabe A, "Toward use of the leaves of Perilla frutescens(L. )Britton var. Acuta kudo(red perilla)with Japanese dietary pickled plum(Umeboshi)", Journal of Oleo Science, 55, pp.413~422 (2006)
  32. Solano F, "Hypopigmenting agents : An updated review on biological, chemical and clinical aspects", Pigment Cell Research, 19, pp.550~571 (2006)
  33. Wang KH, "Cosmetic applications of selected traditional Chinese herbal medicines", Journal of Ethnopharmacology, 106, pp.3593~3599 (2006)
  34. 양서진, "연교 추출물의 항산화활성 및 미백 효과", 한국약용작물학회지, 19(6), pp.472~477 (2011), 한국약용작물학회

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