피부에서의 백삼 분획물의 멜라닌 색소 저해효과
Inhibitory Effect of White Ginseng Fraction on Skin Pigmentation
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초록
In our previous study, ethylacetate fraction of white ginseng (root of Panax ginseng C.A. Meyer) extractinhibited mushroom tyrosinase activity and melanin production in melanocytes. This study examined its effects on theexpresion of melanin biosynthesis-related enzymes to explore the depigmenting pathway. Moreover, depigmenting effect onanimal skin was examined using UV-B induced hyperpigmented skin of brown guinea pigs. The ethylacetate fraction of thewhite ginseng extract exhibited depigmenting activity in the skin of brown guinea pig without visible edema. In addition, thisfraction reduced tyrosinase expression in melanocytes. The results suggested that ethylacetate fraction of white ginsengextract might be used as skin depigmenting material by inhibition of tyrosinase activity and expression.
Abstract
In our previous study, ethylacetate fraction of white ginseng (root of Panax ginseng C.A. Meyer) extractinhibited mushroom tyrosinase activity and melanin production in melanocytes. This study examined its effects on theexpresion of melanin biosynthesis-related enzymes to explore the depigmenting pathway. Moreover, depigmenting effect onanimal skin was examined using UV-B induced hyperpigmented skin of brown guinea pigs. The ethylacetate fraction of thewhite ginseng extract exhibited depigmenting activity in the skin of brown guinea pig without visible edema. In addition, thisfraction reduced tyrosinase expression in melanocytes. The results suggested that ethylacetate fraction of white ginsengextract might be used as skin depigmenting material by inhibition of tyrosinase activity and expression.
참고문헌 (15)
- Ando H, "Linoleic acid and α-linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin", Arch. Dermatol. Res, 290, pp.375~381 (1998)
- 최상윤, "도깨비부채 뿌리 추출물의 멜라닌 생성억제효과", 한국약용작물학회지, 14(1), pp.27~30 (2006), 한국약용작물학회
- Fang J, "Functional expression and characterization of aegypi dopachrome conversion enzyme", Biochem. Biophys. Res. Commun, 290, pp.287~293 (2002)
- Hill HZ, "Melanin: a two edged sword?", Pigment Cell Res, 10, pp.158~161 (1997)
- 황은영, "백삼과 홍삼의 페놀성 성분 함량 및 멜라닌 생성억제효과", Journal of Ginseng Research, 30(2), pp.82~87 (2006), 고려인삼학회
- Iozumi K, "Role of tyrosinase as the determinant of pigmentation in cultured human melanocytes", J. Invest. Dermatol, 100, pp.806~811 (1993)
- Kim KS, "Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression", Pigment Cell Res, 19, pp.90~98 (2005)
- 공연희, "도깨비 부채 뿌리 추출물의 피부 과다색소침착에 미치는 영향", 한국약용작물학회지, 15(6), pp.434~436 (2007), 한국약용작물학회
- Lin JY, "Melanocyte biology and skin pigmentation", Nature, 455, pp.843~850 (2007)
- Marmol V, "Tyrosinase and related protein in mammalian pigmentation", FEBS Lett, 381, pp.165~168 (1996)
- Parvez S, "Survey and mechanism of skin depigmenting and lightening agents", Phytother. Res, 20, pp.921~934 (2006)
- Pawelek JM, "After dopachrome?", Pigment Cell Res, 4, pp.53~62 (1991)
- Slominski A, "Melanin pigmentation in mammalian skin and its hormonal regulation", Physiol. Rev, 84, pp.1155~1228 (2004)
- Tsukamoto K, "A second tyrosinase related protein, TRP-2, is a melanogenic enzyme termed dopa chrome tautomerase", EMBO J, 11, pp.519~526 (1992)
- Wang N, "Tyrosinase maturation through the mammalian secretory pathway: bringing color to life", Pigment Cell Res, 19, pp.3~18 (2006)