Ameliorating Effects of Cinnamomum loureiroi and Rosa laevigata Extracts Mixture against Trimethyltin-induced Learning and Memory Impairment Model
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Background: A critical features of Alzheimer’s disease (AD) is cognitive dysfunction, which partly arises from decreased in acetylcholine levels. AD afftected brains are characterized by extensive oxidative stress, which is thought to be primarily induced by the amyloid beta (Aβ) peptide. In a previous study, Cinnamomum loureiroi tincture inhibited acetylcholinesterase (AchE) activity. That study identified AChE inhibitor in the C. loureiroi extract. Furthermore, the C. loureiroi extract enhanced memory in a trimethyltin (TMT)-induced model of cognitive dysfunction, as assessed via two behavioral tests. Rosa laevigata extract protected against oxidative stress-induced cytotoxicity. Administrating R. laevigata extracts to mice significantly reversed Aβ-induced learning and memory impairment, as shown in behavioral tests. Methods and Results: We conducted behavioral to examine the synergistic effects of C. loureiroi and R. laevigata extracts in inhibiting AChE and counteracting TMT-induced learning and memory losses. We also performed biochemical assays. The biochemical results showed a relationship between increased oxidative stress and cholinergic neurons damage in TMT-treated mice. Conclusions: A diet containing C. loureiroi and R. laevigata extracts ameliorated learning and memory impairments in the Y-maze and passive avoidance tests, and exerted synergistic inhibitory effect against AChE and lipid peroxidation.
Abstract
Background: A critical features of Alzheimer’s disease (AD) is cognitive dysfunction, which partly arises from decreased in acetylcholine levels. AD afftected brains are characterized by extensive oxidative stress, which is thought to be primarily induced by the amyloid beta (Aβ) peptide. In a previous study, Cinnamomum loureiroi tincture inhibited acetylcholinesterase (AchE) activity. That study identified AChE inhibitor in the C. loureiroi extract. Furthermore, the C. loureiroi extract enhanced memory in a trimethyltin (TMT)-induced model of cognitive dysfunction, as assessed via two behavioral tests. Rosa laevigata extract protected against oxidative stress-induced cytotoxicity. Administrating R. laevigata extracts to mice significantly reversed Aβ-induced learning and memory impairment, as shown in behavioral tests. Methods and Results: We conducted behavioral to examine the synergistic effects of C. loureiroi and R. laevigata extracts in inhibiting AChE and counteracting TMT-induced learning and memory losses. We also performed biochemical assays. The biochemical results showed a relationship between increased oxidative stress and cholinergic neurons damage in TMT-treated mice. Conclusions: A diet containing C. loureiroi and R. laevigata extracts ameliorated learning and memory impairments in the Y-maze and passive avoidance tests, and exerted synergistic inhibitory effect against AChE and lipid peroxidation.
참고문헌 (22)
- Berchtold NC, "Evolution in the conceptualization of dementia and Alzheimer’s disease : Grecoroman period to the 1960s", Neurobiology of Aging, 19, pp.173~189 (1998)
- Butterfield DA, "Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer’s disease and mild cognitive impairment", Free Radical Biology and Medicine, 43, pp.658~677 (2007)
- 최수정, "2,4-Di-tert-butylphenol from Sweet Potato Protects Against Oxidative Stress in PC12 Cells and in Mice", Journal of Medicinal Food, 16(11), pp.977~983 (2013), 한국식품영양과학회[DOI]
- Choi SJ, "Protective effect of Rosa laevigata against amyloid beta peptide-induced oxidative stress", Amyloid : The Journal of Protein Folding Disorders, 13, pp.6~12 (2006)
- Choi SJ, "Ameliorative effect of 1, 2-benzenedicarboxylic acid dinonyl ester against amyloid beta peptide-induced neurotoxicity", Amyloid : The Journal of Protein Folding Disorders, 16, pp.15~24 (2009)
- 최수정, "Perilla frutescens Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity", Journal of Medicinal Food, 19(3), pp.281~289 (2016), 한국식품영양과학회[DOI]
- Ellman GL, "A new and rapid colorimetric determination of acetylcholinesterase activity", Biochemical Pharmacology, 7, pp.88~95 (1961)
- Geloso MC, "Trimethyltininduced hippocampal degeneration as a tool to investigate neurodegenerative processes", Neurochemistry International, 58, pp.729~738 (2011)
- Hestrin S, "The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application", Journal of Biological Chemistry, 180, pp.249~261 (1949)
- Inestrosa NC, "Acetylcholinesterase accelerates assembly of amyloid-β-peptides into Alzheimer's fibrils : Possible role of the peripheral site of the enzyme", Neuron, 16, pp.881~891 (1996)
- 정명환, "Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice", 한국약용작물학회지, 20(1), pp.8~15 (2012), 한국약용작물학회
- Kim CR, "2, 4-Bis(1, 1-dimethylethyl)phenol from Cinnamomum loureirii improves cognitive deficit, cholinergic dysfunction, and oxidative damage in tmt-treated mice", Biological and Pharmaceutical Bulletin, 40, pp.932~935 (2017)
- Kim CR, "Cinnamomum loureirii extract inhibits acetylcholinesterase activity and ameliorates trimethyltin-induced cognitive dysfunction in mice", Biological and Pharmaceutical Bulletin, 39, pp.1130~1136 (2016)
- Kim JK, "Effects of methoxsalen from Poncirus trifoliata on acetylcholinesterase and trimethyltininduced learning and memory impairment", Bioscience Biotechnology and Biochemistry, 75, pp.1984~1989 (2011)
- Loullis CC, "Hippocampal muscarinic receptor loss following trimethyl tin administration", Pharmacology Biochemistry and Behavior, 22, pp.147~151 (1985)
- McGleenon BM, "Acetylcholinesterase inhibitors in Alzheimer’s disease", British Journal of Clinical Pharmacology, 48, pp.471~480 (1999)
- Nabeshima T, "Memory impairment and neuronal dysfunction induced by β-amyloid protein in rats", The Tohoku Journal of Experimental Medicine, 174, pp.241~249 (1994)
- Ohno K, "Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans", Proceedings of the National Academy of Sciences of the United States of America, 98, pp.2017~2022 (2001)
- Shuto M, "Endogenous and exogenous glucocorticoids prevent trimethyltin from causing neuronal degeneration of the mouse brain in vivo : Involvement of oxidative stress pathways", Journal of Pharmacological Sciences, 110, pp.424~436 (2009)
- Smith DG, "The redox chemistry of the Alzheimer’s disease amyloid β peptide", Biochimica et Biophysica Acta(BBA)-Biomembranes, 1768, pp.1976~1990 (2007)
- Wang X, "Acute trimethyltin exposure induces oxidative stress response and neuronal apoptosis in Sebastiscus marmoratus", Aquatic Toxicology, 90, pp.58~64 (2008)
- 고운철, "미성숙 진귤 과피 추출물이 신경세포 사멸에 미치는 영향", 한국약용작물학회지, 23(2), pp.144~149 (2015), 한국약용작물학회[DOI]