금은화에서 분리한 Kaempferol-3-O-glucoside의 글루타메이트로 유도시킨 산화적 스트레스에 대한 HT22 신경세포 보호활성
Kaempferol-3-O-glucoside Isolated from Lonicera japonica Protects Neuronal HT22 Cells against Glutamate-Induced Oxidative Stress
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Background: In this study, we aim to test the neuroprotective activity of kaempferol-3-O-glucoside in HT22 cells originating from mice hippocam against glutamate induced oxidative stress and to elucidate the mechanisms of action of this neuroprotective activity. Methods and Results: Pretreatment of HT22 cells with kaempferol-3-O-glucoside increased cell viability after exposure to glutamate induced oxidative stress. Kaempferol-3-O-glucoside decreased reactive oxygen species and intracellular Ca2+ concentration, which increased with glutamate induced oxidative stress. Moreover, kaempferol-3-O-glucoside maintained the mitochondrial membrane potential at control levels, increased glutathione reductase and glutathione peroxidase levels, and synthesized high levels of the endogenous antioxidant glutathione. Conclusions: Overall, these results suggest that kaempferol-3-O-glucoside isolated from Lonicera japonica exerted a potent neuroprotective activity in glutamate injured HT22 cells through the antioxidative pathway and can be potentially used for the treatment or prevention of Alzheimer's disease.
Abstract
Background: In this study, we aim to test the neuroprotective activity of kaempferol-3-O-glucoside in HT22 cells originating from mice hippocam against glutamate induced oxidative stress and to elucidate the mechanisms of action of this neuroprotective activity. Methods and Results: Pretreatment of HT22 cells with kaempferol-3-O-glucoside increased cell viability after exposure to glutamate induced oxidative stress. Kaempferol-3-O-glucoside decreased reactive oxygen species and intracellular Ca2+ concentration, which increased with glutamate induced oxidative stress. Moreover, kaempferol-3-O-glucoside maintained the mitochondrial membrane potential at control levels, increased glutathione reductase and glutathione peroxidase levels, and synthesized high levels of the endogenous antioxidant glutathione. Conclusions: Overall, these results suggest that kaempferol-3-O-glucoside isolated from Lonicera japonica exerted a potent neuroprotective activity in glutamate injured HT22 cells through the antioxidative pathway and can be potentially used for the treatment or prevention of Alzheimer's disease.
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