Anti-diabetic Effect of Opuntia humifusa Extracts in Diabetic db/db Mice
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Background: This study examined the anti-diabetic effects of Opuntia. humifusa extract (OHE) in diabetic db/db mice. Methods and Results: The 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity and α- glucosidase and α-amylase inhibitory activities of OHE (oral administration for 4 weeks) was eval- uated using biochemical parameters and histological analyses of the pancreas. Oral administration of OHE reduced plasma glucose and fructosamine levels, without affecting body weight or food intake. Additionally, it improved blood lipid parameters and restored the of islet structure in dia- betic db/db mice. Conclusion: The present study provides evidence for the anti-diabetic effect of OHE in db/db mice. These results suggest that OHE can be used as a medicinal supplement or functional foods for anti-diabetic therapy.
Abstract
Background: This study examined the anti-diabetic effects of Opuntia. humifusa extract (OHE) in diabetic db/db mice. Methods and Results: The 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity and α- glucosidase and α-amylase inhibitory activities of OHE (oral administration for 4 weeks) was eval- uated using biochemical parameters and histological analyses of the pancreas. Oral administration of OHE reduced plasma glucose and fructosamine levels, without affecting body weight or food intake. Additionally, it improved blood lipid parameters and restored the of islet structure in dia- betic db/db mice. Conclusion: The present study provides evidence for the anti-diabetic effect of OHE in db/db mice. These results suggest that OHE can be used as a medicinal supplement or functional foods for anti-diabetic therapy.
참고문헌 (28)
- Bouche C, "The cellular fate of glucose and its relevance in type 2 diabetes", Endocrine Reviews, 25, pp.807~830 (2004)
- Casirola DM, "α-Glucosidase inhibitors prevent diet-induced increases in intestinal sugar transport in diabetic mice", Metabolism, 55, pp.832~841 (2006)
- Chavez-Santoscoy RA., "Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity of nine prickly pear(Opuntia spp. )juices", Plant Foods for Human Nutrition, 64, pp.146~152 (2009)
- Cho JY, "Radical scavenging and anti-inflammatory activity of extracts from Opuntia humifusa Raf", Journal of Pharmacy and Pharmacology, 58, pp.113~119 (2006)
- Dinis TC, "Action of phenolic derivatives(acetaminophen, salicylate, and 5-aminosalicylate)as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers", Archives of Biochemistry and Biophysics, 315, pp.161~169 (1994)
- du Toit R, "Comparison of the antioxidant content of fruits, vegetables and teas measured as vitamin C equivalents", Toxicology, 166, pp.63~69 (2001)
- Gao J, "Combined effects of green tea extracts, green tea polyphenols or epigallocatechin gallate with acarbose on inhibition against alpha-amylase and alpha-glucosidase in vitro", Molecules, 18, pp.11614~11623 (2013)
- Gao T, "Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb", International Journal of Biological Macromolecules, 49, pp.580~586 (2011)
- Goldstein BJ, "Insulin resistance as the core defect in type 2 diabetes mellitus", American Journal of Cardiology, 90, pp.3G~10G (2002)
- Gurzov EN, "Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2", Cell Metabolism, 20, pp.85~102 (2014)
- Hahm SW, "Opuntia humifusa stems lower blood glucose and cholesterol levels in streptozotocin-induced diabetic rats", Nutrition Research, 31, pp.479~487 (2011)
- Han AR, "Inhibitory effect of Opuntia humifusa fruit water extract on solar ultraviolet- induced MMP-1 expression", International Journal of Molecular Sciences, 19, pp.2503~ (2018)
- Howard BV, "Lipoprotein metabolism in diabetes mellitus", Journal of Lipid Research, 28, pp.613~628 (1987)
- Ihara Y, "Hyperglycemia causes oxidative stress in pancreatic β-cells of GK rats, a model of type 2 diabetes", Diabetes, 48, pp.927~932 (1999)
- Isomaa B, "Cardiovascular morbidity and mortality associated with the metabolic syndrome", Diabetes Care, 24, pp.683~689 (2001)
- Kang JY, "Opuntia humifusa supplementation increased bone density by regulating parathyroid hormone and osteocalcin in male growing rats", International Journal of Molecular Sciences, 13, pp.6747~6756 (2012)
- Kang YR, "Anti-obesity and anti-diabetic effects of Yerba Mate(Ilex paraguariensis)in C57BL", 6J mice fed a high-fat diet, 2012, pp.28, 23~29
- Koh LW, "Evaluation of different teas against starch digestibility by mammalian glycosidases", Journal of Agricultural and Food Chemistry, 58, pp.148~154 (2010)
- Kumar S, "alpha-glucosidase inhibitors from plants : A natural approach to treat diabetes", Pharmacognosy Reviews, 5, pp.19~29 (2011)
- Lee EJ, "Anti-diabetic and lipid profile effect of Astragalus membranaceus(Fisch. )Bunge fermented by Aspergillus awamori in db", db mice, 2021, pp.29, 263~272
- Liu F, "An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation inhibitory activities in 3T3-L1 cells", The Journal of Nutrition, 131, pp.2242~2247 (2001)
- Ngoc LTN, "Beneficial effects of Opuntia humifusa(Korean Cheonnyuncho)on human health based on antioxidant properties : Systematic review and meta-analysis", Antioxidants, 12, pp.174~ (2023)
- Shin JE, "Hypoglycemic activity of Opuntia ficus-indica var. sabotan on alloxan-or streptozotocin-induced diabetic mice", Korean Journal of Pharmacognosy, 34, pp.75~79 (2003)
- Wang X, "High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS", Toxicology Letters, 224, pp.16~23 (2014)
- Watson RT, "Intracellular organization of insulin signaling and GLUT4 translocation", Recent Progress in Hormone Research, 56, pp.175~193 (2001)
- Yang EI, "Biological activities of water-soluble polysaccharides from Opuntia humifusa stem in high-fat-diet-fed mice", Jouranl of Food Biochemistry, 43, pp.e12806~ (2019)
- Yoo CY, "Opuntia humifusa aqueous extract alleviates ethanol-induced gastric ulcer in a mouse model", Asian Pacific Journal of Tropical Biomedicine, 10, pp.403~410 (2020)
- Yoon JA, "Effects of Opuntia ficus-indica complex on lipid metabolism in streptozotocin-induced diabetic rats", Korean Journal of Food and Nutrition, 26, pp.526~534 (2013)