예쁜꼬마선충을 이용한 홍삼 추출물의 항스트레스, 수명 연장 효능 평가 및 파킨슨 질환에의 효과 연구
Effects of Red Ginseng Extracts on Response to Environmental Stress, Lifespan, and Parkinson’s Disease in Caenorhabditis elegans
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Cellular oxidative damage caused by reactive oxygen species, byproducts of intra- cellular metabolic processes, is considered a major causal factor of aging. Many anti-oxidant mole- cules have been studied for their anti-aging and lifespan-extending effects in various model organisms ranging from yeast to mice. Methods and Results: This study examined the effects of red ginseng extract on the stress response, lifespan, and age-related diseases using Caenorhabditis elegans as a model system. Red ginseng extract shows anti-oxidant activity in vitro and in vivo. Resistance to heat stress and ultra- violet irradiation was also significantly enhanced by red ginseng extract. Treatment with a 1/10 dilution of red ginseng extracts increased the mean and maximum lifespans without reducing fertil- ity, which is frequently observed in many lifespan-extending interventions. In a genetic model of Parkinson’s disease, red ginseng extract completely blocked the degeneration of dopaminergic neu- rons and decreased alpha-synuclein expression. Conclusions: Red ginseng extracts have anti-stress and lifespan-extending effects, and can reduce the risk of Parkinson’s disease. These findings suggested that red ginseng is a strong candidate for the development of novel nutriceuticals against aging and Parkinson’s disease.
Abstract
Background: Cellular oxidative damage caused by reactive oxygen species, byproducts of intra- cellular metabolic processes, is considered a major causal factor of aging. Many anti-oxidant mole- cules have been studied for their anti-aging and lifespan-extending effects in various model organisms ranging from yeast to mice. Methods and Results: This study examined the effects of red ginseng extract on the stress response, lifespan, and age-related diseases using Caenorhabditis elegans as a model system. Red ginseng extract shows anti-oxidant activity in vitro and in vivo. Resistance to heat stress and ultra- violet irradiation was also significantly enhanced by red ginseng extract. Treatment with a 1/10 dilution of red ginseng extracts increased the mean and maximum lifespans without reducing fertil- ity, which is frequently observed in many lifespan-extending interventions. In a genetic model of Parkinson’s disease, red ginseng extract completely blocked the degeneration of dopaminergic neu- rons and decreased alpha-synuclein expression. Conclusions: Red ginseng extracts have anti-stress and lifespan-extending effects, and can reduce the risk of Parkinson’s disease. These findings suggested that red ginseng is a strong candidate for the development of novel nutriceuticals against aging and Parkinson’s disease.
참고문헌 (30)
- Carr AC, "Vitamin C and immune function", Nutrients, 9, pp.1~25 (2017)
- Du X, "The role of α-synuclein oligomers in parkinson’s disease", International Journal of Molecular Sciences, 21, pp.1~17 (2020)
- Finkel T, "Signal transduction by reactive oxygen species", Journal of Cell Biology, 194, pp.7~15 (2011)
- Golden TR, "Oxidative stress and aging : beyond correlation", Aging Cell, 1, pp.117~123 (2002)
- Gong L, "Neuroprotective mechanisms of ginsenoside Rb1 in central nervous system diseases", Frontiers in Pharmacology, 13, pp.1~25 (2022)
- Gruber J, "Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans", Annals of the New York Academy of Sciences, 1100, pp.530~542 (2007)
- Guo Y, "Mitochondria-wide association study of common variants in osteoporosis", Annals of Human Genetics, 75, pp.569~574 (2011)
- Harman D, "Aging : A theory based on free radical and radiation chemistry", Journal of Gerontology, 11, pp.298~300 (1956)
- Hong CE, "Anti-inflammatory and anti-oxidative effects of Korean red ginseng extract in human keratocytes", Immune Network, 11, pp.42~49 (2011)
- Hughes SE, "Genetic and pharmacological factors that influence reproductive aging in nematodes", PLOS Genetics, 3, pp.e25~ (2007)
- Kim CK, "Buckwheat extract increases resistance to oxidative stress and lifespan in Caenorhabditis elegans", Korean Journal of Medicinal Crop Science, 21, pp.1~6 (2013)
- Kim JS, "Selenocysteine modulates resistance to environmental stress and confers anti-aging effects in C. elegans", Clinics, 72, pp.491~498 (2017)
- Kim SA, "Butein increases resistance to oxidative stress and lifespan with positive effects on the risk of age-related diseases in Caenorhabditis elegans", Antioxidants, 13, pp.155~ (2024)
- Kwak YS, "Protective effect of red ginseng non-saponin fraction on toxicity induced by 2, 3, 7, 8-Tetrachlorodibenzo-ρ-dioxin in rats", Korean Journal of Medicinal Crop Science, 29, pp.201~209 (2021)
- Lane RK, "The role of mitochondrial dysfunction in age-related diseases", Biochimica et Biophysica Acta, 1847, pp.1387~1400 (2015)
- Liguori I, "Oxidative stress, aging, and diseases", Clinical Interventions in Aging, 13, pp.757~772 (2018)
- Li X, "Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition through inhibiting NLRP1 inflammasome and autophagy dysfunction in APP", PS1 mice, 2023, pp.27, 6~
- Lopez-Otin C, "The hallmarks of aging", Cell, 153, pp.1194~1217 (2013)
- Nyarko K., "Quercetin - Effects on human health", pp.89~103 (2024), Intechopen
- Oh SI, "Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans", Clinics, 70, pp.380~386 (2015)
- Oh SI, "N-acetyl-L-cysteine mimics the effect of dietary restriction on lifespan and reduces amyloid beta-induced toxicity in Caenorhabditis elegans", Food Science and Biotechnology, 26, pp.783~790 (2017)
- Park SH, "Effects of fisetin, a plant-derived flavonoid, on response to oxidative stress, aging, and age-related diseases in Caenorhabditis elegans", Pharmaceuticals, 15, pp.1528~ (2022)
- Peto R, "Asymptotically efficient rank invariant test procedures", Journal of the Royal Statistical Society. Series A (General), 135, pp.185~207 (1972)
- Ristow M, "Extending life span by increasing oxidative stress", Free Radical Biology and Medicine, 51, pp.327~336 (2011)
- Santos DF, "Oxidative stress and aging : synergies for age related diseases", FEBS Letters, 598, pp.2074~2091 (2024)
- Schieber M, "ROS function in redox signaling and oxidative stress", Current Biology, 24, pp.453~462 (2014)
- Seong BJ, "Antioxidant activity and angiotensin converting enzyme by Lycii fructus extracts prepared by adding white ginseng and red ginseng", Korean Journal of Medicinal Crop Science, 26, pp.370~381 (2018)
- Varanasi SS, "Mitochondrial DNA Deletion Associated Oxidative Stress and Severe Male Osteoporosis", Osteoporosis International, 10, pp.143~149 (1999)
- Won SM, "Tenebrio molitor extracts modulate the response to environmental stressors and extend lifespan in Caenorhabditis elegans", Journal of Medicinal Food, 19, pp.938~944 (2016)
- Xia J, "Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches", Science Advances, 8, pp.eabj1262~ (2022)