주의력결핍/과잉행동 성향을 가진 대학생의 공간 작업 기억 결함에 관한 사건관련전위 연구
An event-related potential study of spatial working memory deficits in college students with ADHD traits
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초록
본 연구는 주의력결핍/과잉행동(attention deficit/hyperactivity; ADHD) 성향을 가지고 있는 대학생의 공간 작업 기억의 결함을 사건관련전위를 사용하여 조사하였다. Conners’ Adult ADHD Rating Scale-한국판과 성인 ADHD 자기보고 척도의 점수에 근거하여 ADHD 성향군(n=31)과 정상통제군(n=32)을 선정하였다. 공간 작업 기억의 측정에 공간 2-back 과제가 사용되었는데, 이 과제는 2 시행 전에 제시되었던 자극의 위치가 현재 제시되는 자극의 위치와 일치하는 일치 조건과 일치하지 않는 불일치 조건으로 구성되며, 일치 조건에서 가능한 빠르고 정확하게 반응하는 것이 요구된다. 행동 자료의 분석 결과, 정상통제군에 비해 ADHD 성향군이 일치 조건에서 유의하게 낮은 반응 정확률을 보였다. 사건관련전위의 경우, 정상통제군에 비해 ADHD 성향군에서 유의하게 지연된 N200 잠재기와 감소된 P300 진폭이 관찰되었다. 즉, ADHD 성향군은 공간 작업 기억 과제에서 행동 수행의 저하뿐만 아니라 작업 기억 과정에서 요구되는 자극 간의 비교 및 인출(N200), 정보의 최신화(P300)에서 정상통제군에 비해 저하된 신경생리적 기능을 보였다. 따라서 본 연구의 결과는 ADHD 성향군이 공간 작업 기억의 결함과 공간 작업 기억에 관여하는 신경생리적 기능의 결함 가지고 있음을 시사한다.
Abstract
This study investigated spatial working memory deficits in college students with attention-deficits/hyperactivity disorder (ADHD) traits using event-related potentials (ERPs) and spatial 2-back task. Based on the scores of the Conners’ Adult ADHD Rating Scale and Adult ADHD Self-Report Scale, ADHD-trait (n=31) and control (n=32) groups were selected. Participants were required to determine whether a current stimulus was in the same location as the stimulus presented 2 trials earlier. The ADHD-trait group showed significantly lower accuracy rate than the control group on the spatial 2-back task. In terms of ERPs, the ADHD-trait group exhibited significantly longer N200 latency as well as significantly smaller P300 amplitudes than the control group. The N200 and P300 components reflect the comparison of stimulus type, memory retrieval and memory updating, respectively. Therefore, the present results indicate that college students with ADHD traits have difficulties in comparison of relevant/irrelevant stimuli, memory retrieval and updating information in working memory. Results of this study further indicate that college students with ADHD traits have neurophysiological dysfunction associated with spatial working memory.
참고문헌 (91)
- Adler, L. A., "Adult ADHD Self-Report Scale-v1. 1 (ASRS-v1. 1) Symptom Checklist" (2003), World Health Organization
- American Psychiatric Association, "Diagnostic and statistical manual of mental disorders" (2013), American Psychiatric Association Press
- Baddeley, A. D., "Working memory, thought, and action" (2007), Oxford University Press
- Baddeley, A. D., "The psychology of learning and motivation", pp.47~89 (1974), Academic Press
- Barkley, R. A., "Behavioral inhibition, sustained attention, and executive functions : Constructing a unifying theory of ADHD", Psychological Bulletin, 121, pp.65~94 (1997)
- Barkley, R. A., "The relevance of the still lectures to attention-deficit", hyperactivity disorder : a commentary, 2006, pp.10, 137~140
- Barkley, R. A., "Adult ADHD : What the science says" (2008), Guilford Press
- Bayerl, M., "Disturbed brain activation during a working memory task in drug-naive adult patients with ADHD", Neuroreport, 21, pp.442~446 (2010)
- Bedard, A. C., "Reduced prefrontal efficiency for visuospatial working memory in attention-deficit", hyperactivity disorder, 2014, pp.53, 1020~1030
- Bledowski, C., "Localizing P300 generators in visual target and distractor processing : A combined event-related potential and functional magnetic resonance imaging study", The Journal of Neuroscience, 24, pp.9353~9360 (2004)
- Bollmann, S., "Age-dependent and-independent changes in attention-deficit", hyperactivity disorder(ADHD)during spatial working memory performance, 2017, pp.18, 279~290
- Brown, T. E., "Executive function impairments in high IQ adults with ADHD", Journal of Attention Disorders, 13, pp.161~167 (2009)
- Castellanos, F. X., "Neuroscience of attention-deficit", hyperactivity disorder : The search for endophenotypes, 2002, pp.3, 617~628
- 장문선, "성인 ADHD 성향집단의 하위군집 탐색:우울, 자아 존중감 및 대인관계 문제를 중심으로", Korean Journal of Clinical Psychology, 26(4), pp.827~843 (2007), 한국임상심리학회[DOI]
- Cocchi, L., "Altered functional brain connectivity in a non-clinical sample of young adults with attention-deficit", hyperactivity disorder, 2012, pp.32, 17753~17761
- Colzato, L. S., "Working Memory Reloaded : Tyrosine Repletes Updating in the N-Back Task", Frontiers in Behavioral Neuroscience, 7, pp.200~ (2013)
- Conners, C. K., "Conners’ Adult ADHD rating scales : Technical manual" (1999), Multi-Health Systems
- Crego, A., "Binge drinking affects attentional and visual working memory processing in young university students", Alcoholism, Clinical and Experimental Research, 33, pp.1870~1879 (2009)
- Cubillo, A., "Structural and functional brain imaging in adult attention-deficit", hyperactivity disorder, 2010, pp.10, 603~620
- Cubillo, A., "Drug-specific laterality effects on frontal lobe activation of atomoxetine and methylphenidate in attention deficit hyperactivity disorder boys during working memory", Psychological Medicine, 44, pp.633~646 (2014)
- Daffner, K. R., "Mechanisms underlying age-and performance-related differences in working memory", Journal of Cognitive Neuroscience, 23, pp.1298~1314 (2011)
- Dinn, W. M., "Adult attention-deficit", hyperactivity disorder: Neuropsychological correlates and clinical presentation, 2001, pp.46(1-2), 114~121
- Donchin, E., "Is the P300 component a manifestation of context updating?", Behavioral and Brain Sciences, 11, pp.357~374 (1988)
- Dores, A. R., "Study of behavioural and neural bases of visuo-spatial working memory with an fMRI paradigm based on an n-back task", Journal of Neuropsychology, 11, pp.122~134 (2017)
- Dowson, J. H., "Impaired spatial working memory in adults with attention-deficit", hyperactivity disorder : Comparisons with performance in adults with borderline personality disorder and in control subjects, 2004, pp.110, 45~54
- Ecker, U. K., "The components of working memory updating: An experimental decomposition and individual differences", Journal of Experimental Psychology. Learning, Memory, and Cognition, 36, pp.170~189 (2010)
- Ehlis, A. C., "Reduced lateral prefrontal activation in adult patients with attention-deficit", hyperactivity disorder(ADHD)during a working memory task : a functional near-infrared spectroscopy(fNIRS)study, 2008, pp.42, 1060~1067
- Elisa, R. N., "Inattention, working memory, and goal neglect in a community sample", Frontiers in Psychology, 7, pp.1428~ (2016)
- First, M. B., "Structured clinical interview for DSM-IV axis I disorder" (1996), New York State Psychiatric Institute
- Folstein, J. R., "Influence of cognitive control and mismatch on the N2 component of the ERP : A review", Psychophysiology, 45, pp.152~170 (2008)
- Fostick, L., "The effect of attention-Deficit", Hyperactivity disorder and methylphenidate treatment on the adult auditory temporal order judgment threshold, 2017, pp.60, 2124~2128
- Gathercole, S. E., "Attentional and executive function behaviours in children with poor working memory", Learning and Individual Differences, 18, pp.214~223 (2008)
- Gevins, A., "High-resolution EEG mapping of cortical activation related to working memory : Effects of task difficulty, type of processing, and practice", Cerebral Cortex, 7, pp.374~385 (1997)
- Hervey, A. S., "Neuropsychology of adults with attention-deficit", hyperactivity disorder : A meta-analytic review, 2004, pp.18, 485~503
- Hudziak, J, J., "A dimensional approach to developmental psychopathology", International Journal of Methods in Psychiatric Research, 16(S1), pp.S16~S23 (2007)
- Huffmeijer, R., "Reliability of event-related potentials : The influence of number of trials and electrodes", Physiology & Behavior, 130, pp.13~22 (2014)
- Hur, J., "Emotional influences on perception and working memory", Cognition & Emotion, 31, pp.1294~1302 (2017)
- Jacola, L. M., "Clinical Utility of the N-back Task in Functional Neuroimaging Studies of Working Memory", Journal of Clinical and Experimental Neuropsychology, 36, pp.875~886 (2014)
- Jaeggi, S. M., "The concurrent validity of the N-back task as a working memory measure", Memory, 18, pp.394~412 (2010)
- 장경미, "주의력결핍", 과잉행동 성향을 가진 대학생의 신경심리 기능에 관한 연구, 2015, pp.20(3), 665~685[DOI]
- Kane, M. J., "Working memory, attention control, and the N-back task : A question of construct validity", Journal of Experimental Psychology, 33, pp.615~622 (2007)
- Kaplan, R. F., "A review of adult ADHD : A neuropsychological and neuroimaging perspective", CNS Spectrums, 7, pp.355~362 (2002)
- Keage, H. A., "ERP indices of working memory updating in AD", HD : Differential aspects of development, subtype, and medication, 2008, pp.25, 32~41
- Kessler, R. C., "The World Health Organization Adult ADHD Self-Report Scale(ASRS) : a short screening scale for use in the general population", Psychological Medicine, 35, pp.245~256 (2005)
- 김호영, "한국판 Conners 성인 ADHD 평정척도의 신뢰도 및 타당도 연구: 대학생 표본을 중심으로", Korean Journal of Clinical Psychology, 24(1), pp.171~186 (2005), 한국임상심리학회
- 김지혜, "The WHO Adult ADHD Self-Report Scale: Reliability and Validity of the Korean Version", PSYCHIATRY INVESTIGATION, 10(1), pp.41~46 (2013), 대한신경정신의학회[DOI]
- 김주영, "성인 ADHD 성향군의 우울․불안과 수면의 질의 관계", 상담학연구, 11(1), pp.75~89 (2010), 한국상담학회[DOI]
- 김명선, "작업 기억의 신경생리적 기전: 사건관련전위 연구", Korean Journal of Clinical Psychology, 23(2), pp.313~326 (2004), 한국임상심리학회
- 김설기, "Deficits in Verbal Working Memory among College Students with Attention- Deficit", Hyperactivity Disorder Traits: An Event-related Potential Study, 2016, pp.14(1), 64~73[DOI]
- Kim, S., "Adult ADHD and working memory : Neural evidence of impaired encoding", Clinical Neurophysiology, 125, pp.1596~1603 (2014)
- Ko, C. H., "Brain activation deficit in increased-load working memory tasks among adults with ADHD using fMRI", European Archives of Psychiatry and Clinical Neuroscience, 263, pp.561~573 (2013)
- Kobel, M., "Effects of methylphenidate on working memory functioning in children with attention deficit", hyperactivity disorder, 2009, pp.13, 516~523
- Kofler, M. J., "ADHD and working memory : the impact of central executive deficits and exceeding storage", rehearsal capacity on observed inattentive behavior, 2010, pp.38, 149~161
- Kok, A., "On the utility of P3 amplitude as a measure of processing capacity", Psychophysiology, 38, pp.557~577 (2001)
- 이상일, "성인 ADHD 성향군의 오류 후 행동 특성", 한국심리학회지: 인지 및 생물, 27(3), pp.519~542 (2015), 한국인지및생물심리학회[DOI]
- 이상일, "성인 ADHD 증상 가장 집단의 연속수행과제 수행 특성", Korean Journal of Clinical Psychology, 35(2), pp.411~433 (2016), 한국임상심리학회[DOI]
- Lee, Y. S., "Validity of short forms of the Korean-Wechsler Adult Intelligence Scale", The Korean Journal of Clinical Psychology, 14, pp.111~116 (1995)
- Lis, S., "Objective measurement of motor activity during cognitive performance in adults with attention-deficit", hyperactivity disorder, 2010, pp.122, 285~294
- Liu, Z. X., "EEG alpha power during maintenance of information in working memory in adults with ADHD and its plasticity due to working memory training : A randomized controlled trial", Clinical Neurophysiology, 127, pp.1307~1320 (2016)
- Lockwood, K. A., "Differentiation of attention-deficit", hyperactivity disorder subtypes : Application of a neuropsychological model of attention, 2001, pp.23, 317~330
- Lopez Zunini, R. A., "Event-related potentials elicited during working memory are altered in mild cognitive impairment", International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology, 109, pp.1~8 (2016)
- Luck, S. J., "An intorduction to the event-related potential technique" (2014), MIT press
- Mariani, M. A., "Neuropsychological and academic functioning in preschool boys with attention deficit hyperactivity disorder", Developmental Neuropsychology, 13, pp.111~129 (1997)
- Martin, J., "Genetic risk for neurodevelopmental traits in the general population", Biological Psychiatry, 76, pp.664~671 (2014)
- Mattfeld, A. T., "Dissociation of working memory impairments and attention-deficit", hyperactivity disorder in the brain, 2015, pp.10, 274~282
- McCabe, D. P., "The Relationship Between Working Memory Capacity and Executive Functioning : Evidence for a Common Executive Attention Construct", Neuropsychology, 24, pp.222~243 (2010)
- Missonnier, P., "EEG anomalies in adult ADHD subjects performing a working memory task", Neuroscience, 241, pp.135~146 (2013)
- Mostert, J. C., "Cognitive heterogeneity in adult attention deficit", hyperactivity disorder : A systematic analysis of neuropsychological measurements, 2015, pp.25, 2062~2074
- Nakao, Y., "Temporal activities during P3 components on the working memory-related brain regions: N-back ERP study", Proceedings of the IEEE-EMBS International Conference on Biomedical and Health Informatics, pp.424~427 (2012)
- Owen, A. M., "N-back working memory paradigm : A meta-analysis of normative functional neuroimaging studies", Human Brain Mapping, 25, pp.46~59 (2005)
- Panagiotidi, M., "Increased microsaccade rate in individuals with ADHD traits", Journal of Eye Movement Research, 10(1), pp.1~9 (2017)
- Panagiotidi, M., "Attention-deficit hyperactivity disorder-like traits and distractibility in the visual periphery", Perception, 46, pp.665~678 (2017)
- Panagiotidi, M., "The relationship between ADHD traits and sensory sensitivity in the general population", Comprehensive Psychiatry, 80, pp.179~185 (2018)
- Polich, J., "Updating P300 : An integrative theory of P3a and P3b", Clinical Neurophysiology, 118, pp.2128~2148 (2007)
- Polich, J., "Cognitive and biological determinants of P300 : An integrative review", Biological Psychology, 41, pp.103~146 (1995)
- Polner, B., "Gently restless : association of ADHD-like traits with response inhibition and interference control", European Archives of Psychiatry and Clinical Neuroscience, 265, pp.689~699 (2015)
- Rogers, M., "Inattention, working memory, and academic achievement in adolescents referred for attention deficit", hyperactivity disorder(ADHD), 2011, pp.17, 444~458
- Rohrbaugh, J. W., "Decision making and the P300 component of the cortical evoked response", Perception & Psychophysics, 15, pp.368~374 (1974)
- Saliasi, E., "The relationship between P3 amplitude and working memory performance differs in young and older adults", PLoS One, 8(5), pp.e63701~ (2013)
- Sandra Kooij, J. J., "Reliability, validity, and utility of instruments for self-report and informant report concerning symptoms of ADHD in adult patients", Journal of Attention Disorders, 11, pp.445~458 (2008)
- 서보경, "성인 주의력 결핍 및 과잉 행동 장애(ADHD)환자의 실행기능 연구", 한국심리학회지:일반, 31(2), pp.301~321 (2012), 한국심리학회
- Silverstein, A. B., "Agreement between a short form and the full scale as a function of the correlation between them", Journal of Clinical Psychology, 45, pp.929~931 (1989)
- Spencer, T. J., "Attention-deficit", hyperactivity disorder : Diagnosis, lifespan, comorbidities, and neurobiology, 2007, pp.32, 631~642
- Strand, M. T., "Improving working memory in children with attention-deficit", hyperactivity disorder : The separate and combined effects of incentives and stimulant medication, 2012, pp.40, 1193~1207
- Stroux, D., "Deficient interference control during working memory updating in adults with ADHD : An event-related potential study", Clinical Neurophysiology, 127, pp.452~463 (2016)
- Sutton, S., "The late positive complex. advances and new problems", Annals of the New York Academy of Sciences, 425, pp.1~23 (1984)
- Tillman, C., "The relation between working memory components and ADHD symptoms from a developmental perspective", Developmental Neuropsychology, 36, pp.181~198 (2011)
- Tucker, D. M., "Spatial sampling of head electrical fields : The geodesic sensor net", Electroencephalography and Clinical Neurophysiology, 87, pp.154~163 (1993)
- van Ewijk, H., "Visuospatial working memory in ADHD patients, unaffected siblings, and healthy controls", Journal of Attention Disorders, 18, pp.369~378 (2014)
- Weyandt, L. L., "Attention Deficit Hyperactivity Disorder From Genes to Patients", pp.457~486 (2005), Humana Press
- Yum T. H., "Manual of the Korean-Wechsler Adult Intelligence Scale" (1992), Korean Guidance Press
