The hepatoprotective effects of silkworm: Insights into molecular mechanisms and implications
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The liver, a multifunctional organ, plays a vital role in maintaining overall health and well-being by regulating metabolism, detoxification, nutrient storage, hormone balance, and immune function. Liver diseases, such as hepatitis, cirrhosis, fatty liver disease, and liver cancer, have significant clinical implications and remain a global health concern. This article reviews the therapeutic potential of silkworm larvae (Bombyx mori) and explores their underlying molecular mechanisms in protecting against liver diseases. Silkworm larvae are rich in proteins, vitamins, minerals, and n-3 fatty acids, making them a promising candidate for therapeutic applications. The anti-inflammatory mechanisms of silkworm larvae involve modulating the production of cytokine such as TNF-α and interleukins, inflammatory enzymes including cyclooxygenase-2 and macrophage polarization, thereby attenuating liver inflammation. Silkworm larvae also exhibit anti-oxidative effects by scavenging free radicals, reducing intracellular reactive oxygen species and enhancing the liver's antioxidant defense system. Moreover, silkworms have been reported to decrease the serum alcohol concentration and lipid accumulation. Understanding the therapeutic properties of silkworm larvae contributes to the development of innovative strategies for liver injury prevention and treatment. Further research is warranted to elucidate the precise signaling pathways involved in the anti-inflammatory and anti-oxidative effects of silkworm larvae, paving the way for potential therapeutic interventions in liver diseases.
Abstract
The liver, a multifunctional organ, plays a vital role in maintaining overall health and well-being by regulating metabolism, detoxification, nutrient storage, hormone balance, and immune function. Liver diseases, such as hepatitis, cirrhosis, fatty liver disease, and liver cancer, have significant clinical implications and remain a global health concern. This article reviews the therapeutic potential of silkworm larvae (Bombyx mori) and explores their underlying molecular mechanisms in protecting against liver diseases. Silkworm larvae are rich in proteins, vitamins, minerals, and n-3 fatty acids, making them a promising candidate for therapeutic applications. The anti-inflammatory mechanisms of silkworm larvae involve modulating the production of cytokine such as TNF-α and interleukins, inflammatory enzymes including cyclooxygenase-2 and macrophage polarization, thereby attenuating liver inflammation. Silkworm larvae also exhibit anti-oxidative effects by scavenging free radicals, reducing intracellular reactive oxygen species and enhancing the liver's antioxidant defense system. Moreover, silkworms have been reported to decrease the serum alcohol concentration and lipid accumulation. Understanding the therapeutic properties of silkworm larvae contributes to the development of innovative strategies for liver injury prevention and treatment. Further research is warranted to elucidate the precise signaling pathways involved in the anti-inflammatory and anti-oxidative effects of silkworm larvae, paving the way for potential therapeutic interventions in liver diseases.
참고문헌 (73)
- Acharya P, "Cellular mechanisms of liver fibrosis", Front Pharmacol, 12, pp.671640~ (2021)
- Bettermann K, "TAK1 suppresses a NEMO-dependent but NF-κBindependent pathway to liver cancer", Cancer cell, 17, pp.481~496 (2010)
- Breuhahn K, "Dysregulation of growth factor signaling in human hepatocellular carcinoma", Oncogene, 25, pp.3787~3800 (2006)
- Browning JD, "Molecular mediators of hepatic steatosis and liver injury", J Clin Invest, 114, pp.147~152 (2004)
- Cantó C, "PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure", Curr Opin Lipidol, 20, pp.98~105 (2009)
- Cho HD, "Solid state fermentation process with Aspergillus kawachii enhances the cancersuppressive potential of silkworm larva in hepatocellular carcinoma cells", BMC Complement Altern Med, 19, pp.241~ (2019)
- 조재민, "Protective Effect of Silkworm (Bombyx mori) Powder against Diethylnitrosamine-induced Hepatotoxicity in Mice", 산업식품공학, 20(4), pp.342~348 (2016), 한국산업식품공학회
- Jae-Min Cho, "Protective Effect of Boiled and Freeze-dried Mature Silkworm Larval Powder Against Diethylnitrosamine-induced Hepatotoxicity in Mice", 대한암예방학회지, 21(3), pp.173~181 (2016), 대한암예방학회[DOI]
- Crusz SM, "Inflammation and cancer : advances and new agents", Nat Rev Clin Oncol, 12, pp.584~596 (2015)
- Deori M, "Antioxidant and antigenotoxic effects of pupae of the muga silkworm Antheraea assamensis", Food Biosci, 5, pp.108~114 (2014)
- Elsebaie EM, "Principles of Nutritional Management in Patients with Liver Dysfunction—A Narrative Review", Livers, 3, pp.190~218 (2023)
- Fan JB, "Antioxidant activities of silk sericin from silkworm Bombyx mori", J Food Biochem, 33, pp.74~88 (2009)
- Friedman SL, "Cytokines and fibrogenesis", Seminars in liver disease (1999), Thieme Medical Publishers, Inc
- Fukata M, "Role of Toll-like receptors in gastrointestinal malignancies", Oncogene, 27, pp.234~243 (2008)
- Gluchowski NL, "Lipid droplets and liver disease : from basic biology to clinical implications", Nat Rev Gastroenterol Hepatol, 14, pp.343~355 (2017)
- Gressner AM, "Roles of TGF-beta in hepatic fibrosis", Front Biosci, 7, pp.793~807 (2002)
- Hong KS, "Silkworm(Bombyx mori)powder supplementation alleviates alcoholic fatty liver disease in rats", J Funct Foods, 43, pp.29~36 (2018)
- Ikejima K, "Leptin receptor–mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat", Gastroenterology, 122, pp.1399~1410 (2002)
- 지상덕, "Nutrition composition differences among steamed and freeze-dried mature silkworm larval powders made from 3 Bombyx mori varieties weaving different colored cocoons", International Journal of Industrial Entomology and Biomaterials, 33(1), pp.6~14 (2016), 한국잠사학회
- Sang Deok Ji, "Nutrient compositions of Bombyx mori mature silkworm larval powders suggest their possible health improvement effects in humans", Journal of Asia-Pacific Entomology, 19(4), pp.1027~1033 (2016), 한국응용곤충학회
- Kang FB, "B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2", STAT3, Cancer Cell Int, pp.2015, 15[DOI]
- Kang PD, "Breeding of New Silkworm Variety Golden silk, a Yellow Cocoon Color for Spring Rearing Season", Korean J Ser Sci, 49, pp.14~17 (2007)
- Karin M, "Nuclear factor-kappaB in cancer development and progression", Nature, 441, pp.431~436 (2006)
- 김용순, "Effect of Silkworm (Bombyx mori) Excrement Powder on the Alcoholic Hepatotoxicity in Rats", 생명과학회지, 18(10), pp.1342~1347 (2008), 한국생명과학회
- Koretz RL, "Nutritional support in liver disease–an updated systematic review", Curr Opin Gastroenterol, 39, pp.115~124 (2023)
- Kunz RI, "L. d. FC Ribeiro and MRM Natali", BioMed Res Int, 2016, pp.8175701~ (2016)
- Lagouge M, "Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha", Cell, 127, pp.1109~1122 (2006)
- Lang A, "Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells", J Hepatol, 33, pp.49~58 (2000)
- 이다영, "Comparative effect of silkworm powder from 3 Bombyx mori varieties on ethanol-induced gastric injury in rat model", International Journal of Industrial Entomology and Biomaterials, 35(1), pp.14~21 (2017), 한국잠사학회
- 이다영, "Comparison of silkworm powder from 3 Bombyx mori varieties on alcohol metabolism in rats", International Journal of Industrial Entomology and Biomaterials, 35(1), pp.22~29 (2017), 한국잠사학회
- Lee DY, "Hepatoprotective effects of steamed and freeze-dried mature silkworm larval powder against ethanol-induced fatty liver disease in rats", Foods, 9, pp.285~ (2020)
- Lee Da-Young, "Hongjam prevents hepatic damage against ethanol-induced fatty liver disease in rats", Journal of Asia-Pacific Entomology, 26(2), pp.1~6 (2023), 한국응용곤충학회[DOI]
- 이다영, "Low dose administration of mature silkworm powder induces gastric mucosal defense factors in ethanol-induced gastric injury rat model", Food Science and Biotechnology, 32(11), pp.1551~1559 (2023), 한국식품과학회[DOI]
- Lee DY, "Administration of steamed and freeze-dried mature silkworm larval powder prevents hepatic fibrosis and hepatocellular carcinogenesis by blocking TGF-β", STAT3 signaling cascades in rats, 2020, pp.9, 568~
- Lieber CS, "Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats", Biochem Biophys Res Comm, 370, pp.44~48 (2008)
- Lin WW, "A cytokine-mediated link between innate immunity, inflammation, and cancer", J Clin Invest, 117, pp.1175~1183 (2007)
- Long X, "Silkworm pupa oil attenuates acetaminophen-induced acute liver injury by inhibiting oxidative stress mediated NF-κB signaling", Food Sci Nutr, 8, pp.237~245 (2020)
- Long YC, "AMP-activated protein kinase signaling in metabolic regulation", J Clin Invest, 116, pp.1776~1783 (2006)
- Louvet A, "Alcoholic liver disease : mechanisms of injury and targeted treatment", Nat Rev Gastroenterol Hepatol, 12, pp.231~242 (2015)
- Maeda S, "IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis", Cell, 121, pp.977~990 (2005)
- Meng X, "Lan HYTGF-Β. The Master Regulator Of Fibrosis", Nat Rev Nephrol, 12, pp.325~338 (2016)
- Moon AM, "Contemporary epidemiology of chronic liver disease and cirrhosis", Clin Gastroenterol Hepatol, 18, pp.2650~2666 (2020)
- Mosser DM, "Exploring the full spectrum of macrophage activation", Nat Rev Immunol, 8, pp.958~969 (2008)
- O’Shea RS, "Alcoholic liver disease", Hepatology, 51, pp.307~328 (2010)
- Park M, "Effect of bombyx mori on the liver protection of non-alcoholic fatty liver disease based on in vitro and in vivo models", Curr Issues Mol Biol, 43, pp.21~35 (2021)
- Potter JJ, "Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration", J Hepatol, 38, pp.281~288 (2003)
- Purushotham A, "Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation", Cell Metab, 9, pp.327~338 (2009)
- Kamidi Rahul, "In vitro screening of anti-skin aging and antioxidant properties of aqueous", solvent extracts from distinctive stages of silkworm (Bombyx mori L.) pupae, 2022, pp.45(1), 1~11[DOI]
- Rasineni K, "Molecular mechanism of alcoholic fatty liver", Indian J Pharmacol, 44, pp.299~ (2012)
- Reddy JK, "Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation", Am J Phys Gastrointest Liver Physiol, 290, pp.G852~G858 (2006)
- Rhyu J, "Newly discovered endocrine functions of the liver", World J Hepatol, 13, pp.1611~ (2021)
- Rogers CQ, "Adiponectin and alcoholic fatty liver disease", IUBMB life, 60, pp.790~797 (2008)
- Rui L, "Energy metabolism in the liver", Compr Physiol, 4, pp.177~ (2014)
- Sahoo A, "Pro-oxidative challenges and antioxidant protection during larval development of non-mulberry silkworm, Antheraea mylitta(Lepidoptera : Saturniidae)", Italian J Zool, 83, pp.3~14 (2016)
- Schulze RJ, "The cell biology of the hepatocyte : A membrane trafficking machine", J Cell Biol, 218, pp.2096~2112 (2019)
- Shek FW, "How can transforming growth factor beta be targeted usefully to combat liver fibrosis?", Eur J Gastroenterol Hepatol, 16, pp.123~126 (2004)
- Suzuki S, "Study of the Antioxidative Effects of Bombyx mori Silk Sericin in Cultures of Murine Retinal Photoreceptor Cells", Molecules, 27, pp.4635~ (2022)
- Svinka J, "STAT3 in hepatocellular carcinoma : new perspectives", Hepat Oncol, 1, pp.107~120 (2014)
- Tabunoki H, "Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson’s disease", PLoS One, 8, pp.e69130~ (2013)
- Tian Y, "Resveratrol supplement inhibited the NF-kappaB inflammation pathway through activating AMPKalpha-SIRT1 pathway in mice with fatty liver", Mol Cell Biochem, 422, pp.75~84 (2016)
- Tsukada S, "Mechanisms of liver fibrosis", Clin Chim Acta, 364, pp.33~60 (2006)
- Waidmann O, "Diagnostic and prognostic significance of cell death and macrophage activation markers in patients with hepatocellular carcinoma", J Hepatol, 59, pp.769~779 (2013)
- Witters LA, "Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5’-AMP-activated protein kinase", J Biol Chem, 267, pp.2864~2867 (1992)
- Xiong S, "Cancer-associated fibroblasts promote stem cell-like properties of hepatocellular carcinoma cells through IL-6", STAT3, Am J Cancer Res, pp.2018, 8[DOI]
- Xu J, "IL-6", STAT3 is a promising therapeutic target for hepatocellular carcinoma, 2021, pp.11, 760971~
- Xu Q, "Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways", Oncogene, 24, pp.5552~5560 (2005)
- Yu H, "Crosstalk between cancer and immune cells : role of STAT3 in the tumour microenvironment", Nat Rev Immunol, 7, pp.41~51 (2007)
- Yun SM, "Gastroprotective effect of mature silkworm, Bombyx mori against ethanol-induced gastric mucosal injuries in rats", J Funct Foods, 39, pp.279~286 (2017)
- Yun SM, "Xanthohumol Interferes with the Activation of TGF-β Signaling in the Process Leading to Intestinal Fibrosis", Nutrients, 15, pp.99~ (2022)
- Zhang F, "TGF-β induces M2-like macrophage polarization via SNAILmediated suppression of a pro-inflammatory phenotype", Oncotarget, 7, pp.52294~ (2016)
- Zhang P, "Similarities and differences : A comparative review of the molecular mechanisms and effectors of NAFLD and AFLD", Front Physiol, 12, pp.710285~ (2021)
- Zhang Y, "Identification and characterization of two novel antioxidant peptides from silkworm pupae protein hydrolysates", Eur Food Res Technol, 247, pp.343~352 (2021)
- Zhang YQ, "Applications of natural silk protein sericin in biomaterials", Biotechnol Adv, 20, pp.91~100 (2002)
