Comparison of silkworm powder from 3 Bombyx mori varieties on alcohol metabolism in rats
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Increased alcohol consumption is a burden on the world because it is associated with various health problems. However, the effects of silkworms on alcohol metabolism have not been studied yet. The hard-to-eat mature silkworms have become easier to ingest recently due to the development of technology, steam-lyophilising mature silkworm larvae. In this study, we investigated and compared the effects of SMSPs from three silkworm varieties, Baekokjam, Golden-silk and Yeonnokjam weaving white, golden, and light green cocoons on alcohol metabolism in vivo. Sprague-Dawley rats pretreated with three SMSPs (0.1 g/kg or 1 g/kg body weight) or normal diet (AIN-76A) for 2 weeks were subjected to intragastric administration of absolute ethanol (3 g/kg body weight, 3 h). Three SMSPs did not affect the final body weight and liver weight. All 3 SMSPs were effective to reduce the enzymes in alcohol metabolism, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), and liver damage and enzymes involved in liver damage, aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Among SMSP from 3 varieties of silkworm, preadministration of 1 g/kg Baekokjam SMSP showed the most effective suppressive effect on the activities of ADH, ALDH, AST and ALT. The Baekokjam SMSP contained higher amounts of beneficial amino acids than Golden-silk or Yeonnokjam SMSP. These results suggest that Baekokjam SMSP might be used as a new and promising candidate for improving alcohol metabolism and liver injury through promoting rapid alcohol metabolism.
Abstract
Increased alcohol consumption is a burden on the world because it is associated with various health problems. However, the effects of silkworms on alcohol metabolism have not been studied yet. The hard-to-eat mature silkworms have become easier to ingest recently due to the development of technology, steam-lyophilising mature silkworm larvae. In this study, we investigated and compared the effects of SMSPs from three silkworm varieties, Baekokjam, Golden-silk and Yeonnokjam weaving white, golden, and light green cocoons on alcohol metabolism in vivo. Sprague-Dawley rats pretreated with three SMSPs (0.1 g/kg or 1 g/kg body weight) or normal diet (AIN-76A) for 2 weeks were subjected to intragastric administration of absolute ethanol (3 g/kg body weight, 3 h). Three SMSPs did not affect the final body weight and liver weight. All 3 SMSPs were effective to reduce the enzymes in alcohol metabolism, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), and liver damage and enzymes involved in liver damage, aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Among SMSP from 3 varieties of silkworm, preadministration of 1 g/kg Baekokjam SMSP showed the most effective suppressive effect on the activities of ADH, ALDH, AST and ALT. The Baekokjam SMSP contained higher amounts of beneficial amino acids than Golden-silk or Yeonnokjam SMSP. These results suggest that Baekokjam SMSP might be used as a new and promising candidate for improving alcohol metabolism and liver injury through promoting rapid alcohol metabolism.
참고문헌 (25)
- Agarwal DP, "Human aldehyde dehydrogenases:Their role in alcoholism", Alcohol, 6, pp.517~523 (1989)
- Cederbaum AI, "Alcohol metabolism", Clin Liver Dis, 16, pp.667~685 (2012)
- Cequera A, "Biomarkers for liver fibrosis: Advances, advantages and disadvantages", Revista de Gastroenterología de México (English Edition), 79, pp.187~199 (2014)
- Jae-Min Cho, "Protective Effect of Boiled and Freeze-dried Mature Silkworm Larval Powder Against Diethylnitrosamine-induced Hepatotoxicity in Mice", 대한암예방학회지, 21(3), pp.173~181 (2016), 대한암예방학회
- Sun-Gil Do, "Silk fibroin hydrolysate exerts an anti-diabetic effect by increasing pancreatic β cell mass in C57BL", KsJ-db, Journal of Veterinary Science, pp.2012, 13(4)[DOI]
- 지상덕, "Nutrition composition differences among steamed and freeze-dried mature silkworm larval powders made from 3 Bombyx mori varieties weaving different colored cocoons", International Journal of Industrial Entomology, 33(1), pp.6~14 (2016), 한국잠사학회
- Sang Deok Ji, "Nutrient compositions of Bombyx mori mature silkworm larval powders suggest their possible health improvement effects in humans", Journal of Asia-Pacific Entomology, 19(4), pp.1027~1033 (2016), 한국응용곤충학회
- Ji SD, "Development of processing technology for edible mature silkworm", J Seri Entomol Sci, 53, pp.38~43 (2015)
- 정수한, "Effect of Beverage Containing Fermented Akebia quinata Extracts on Alcoholic Hangover", Preventive Nutrition and Food Science, 21(1), pp.9~13 (2016), 한국식품영양과학회[DOI]
- Kang PD, "Breeding of new silkworm variety golden silk, a yellow cocoon color for spring rearing season", J Seri Entomol Sci, 49, pp.14~17 (2007)
- 김용순, "Effect of Silkworm (Bombyx mori) Excrement Powder on the Alcoholic Hepatotoxicity in Rats", 생명과학회지, 18(10), pp.1342~1347 (2008), 한국생명과학회
- Kunz RI, "Silkworm sericin : Properties and biomedical applications", Biomed Res Int, 2016, pp.8175701~ (2016)
- Lee S, "Breeding of new silkworm variety "Baeg Ok Jam"", Res Rept RDA, 26, pp.58~64 (1984)
- Louvet A, "Alcoholic liver disease : mechanisms of injury and targeted treatment", Nat Rev Gastroenterol Hepatol, 12, pp.231~242 (2015)
- Mathews S, "Animals models of gastrointestinal and liver diseases. Animal models of alcoholinduced liver disease: pathophysiology, translational relevance, and challenges", Am J Physiol Gastrointest Liver Physiol, 306, pp.G819~G823 (2014)
- Mattia CJ, "Free radical induction in the brain and liver by products of toluene catabolism", Biochem Pharmacol, 46, pp.103~110 (1993)
- Park JE, "Enhanced ethanol catabolism in orphan nuclear receptor SHP-null mice", Am J Physiol Gastrointest Liver Physiol, 310, pp.G799~G807 (2016)
- Park JH, "Green tea extract(Camellia sinensis)fermented by Lactobacillus fermentum attenuates alcohol-induced liver damage", Biosci Biotechnol Biochem, 76, pp.2294~2300 (2012)
- 류강선, "1-Deoxynojirimycin Content and Blood Glucose-Lowering Effect of Silkworm (Bombyx mori) Extract Powder", International Journal of Industrial Entomology, 27(2), pp.237~242 (2013), 한국잠사학회
- Scoccianti C, "Female breast cancer and alcohol consumption: a review of the literature", Am J Prev Med, 46, pp.S16~S25 (2014)
- 서지연, "Enhancement of Alcohol Metabolism by Sprouted Peanut Extract in SD Rats", Preventive Nutrition and Food Science, 19(1), pp.1~4 (2014), 한국식품영양과학회[DOI]
- Shield KD, "Global alcohol exposure estimates by country, territory and region for 2005--a contribution to the Comparative Risk Assessment for the 2010Global Burden of Disease Study", Addiction, 108, pp.912~922 (2013)
- Sung CK, "Taraxerone enhances alcohol oxidation via increases of alcohol dehyderogenase(ADH)and acetaldehyde dehydrogenase(ALDH)activities and gene expressions", Food Chem Toxicol, 50, pp.2508~2514 (2012)
- Swift R, "Alcohol hangover-mechanisms and mediators", Alcohol Health Res World, 22, pp.54~60 (1998)
- Tahir M, "Chrysin modulates ethanol metabolism in Wistar rats : a promising role against organ toxicities", Alcohol Alcohol, 46, pp.383~392 (2011)