2002-2006년 서울지역 입원 환자에서의 급성 바이러스성하기도염의 역학조사
An Epidemiological Study of Acute Viral LowerRespiratory Tract Infections in Hospitalized Children from2002 to 2006 in Seoul, Korea
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초록
Purpose:Acute lower respiratory tract infections (ALRI) in children are mostly caused by viruses. This study aimed to define the causative viruses, and clinical manifestations during 4 years (2002-2006) and to determine seasonal occurrence of viral ALRI in Korean children by using our cumulative 10 year data (1996-2006). Methods:A total of 3,854 hospitalized patients due to viral ALRI at Samsung Medical Center, from October 2002 to July 2006, were analyzed. Nasopharyngeal aspirate was obtained for virus cultures. Respiratory viruses were identified using indirect immunofluorescent staining. Results:Viral agents were isolated in 9.8% (378 cases). The common identified pathogens were parainfluenza virus type 3 (32.3%), respiratory syncytial virus (RSV) (29.6%) and adenovirus (14.0%). The clinical patterns of viral ALRI were pneumonia (73.0%), bronchiolitis (20.9%), croup (3.7%) and tracheobronchitis (2.4%). The occurrence of viral ALRI was highest under 2 years of age. Pneumonia developed mostly by parainfluenza virus type 3 and RSV. The most frequent cause of bronchiolitis was RSV. Croup was frequently caused by parainfluenza virus. During the past 10 years, infections with parainfluenza virus type 3 and RSV epidemically occurred, whereas adenovirus was isolated throughout the study period. Conclusion:We could look through the etiological aspect of ALRI among pediatric inpatients during 10 years in Seoul by adding this 4 year data to the former 6 years data in our hospital. Our results may contribute to prevention and control of viral respiratory tract infections.
Abstract
Purpose:Acute lower respiratory tract infections (ALRI) in children are mostly caused by viruses. This study aimed to define the causative viruses, and clinical manifestations during 4 years (2002-2006) and to determine seasonal occurrence of viral ALRI in Korean children by using our cumulative 10 year data (1996-2006). Methods:A total of 3,854 hospitalized patients due to viral ALRI at Samsung Medical Center, from October 2002 to July 2006, were analyzed. Nasopharyngeal aspirate was obtained for virus cultures. Respiratory viruses were identified using indirect immunofluorescent staining. Results:Viral agents were isolated in 9.8% (378 cases). The common identified pathogens were parainfluenza virus type 3 (32.3%), respiratory syncytial virus (RSV) (29.6%) and adenovirus (14.0%). The clinical patterns of viral ALRI were pneumonia (73.0%), bronchiolitis (20.9%), croup (3.7%) and tracheobronchitis (2.4%). The occurrence of viral ALRI was highest under 2 years of age. Pneumonia developed mostly by parainfluenza virus type 3 and RSV. The most frequent cause of bronchiolitis was RSV. Croup was frequently caused by parainfluenza virus. During the past 10 years, infections with parainfluenza virus type 3 and RSV epidemically occurred, whereas adenovirus was isolated throughout the study period. Conclusion:We could look through the etiological aspect of ALRI among pediatric inpatients during 10 years in Seoul by adding this 4 year data to the former 6 years data in our hospital. Our results may contribute to prevention and control of viral respiratory tract infections.
참고문헌 (26)
- Park JL, "The epidemiology of children who admitted to the municipal hospital in pediatric department", J Korean Pediatr Soc, 28, pp.206~210 (1985)
- Denny FW, "Acute lower respiratory tract infections in nonhospitalized children", J Pediatr, 108, pp.635~646 (1986)
- Choi EH, "The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000- 2005", Clin Infect Dis, 43, pp.585~592 (2006)
- Park HY, "An epidemiological study of acute viral lower respiratory tract infections in hospitalized children from 1996 to 2002 in Seoul, Korea", Pediatr Allergy Respir Dis (Korea), 13, pp.216~226 (2003)
- Hashem M, "Back to basics: molecular tools in the diagnosis and management of infectious diseases", Pediatr Rev, 26, pp.15~20 (2005)
- Meerhoff TJ, "EISS RSV Task Group Surveillance recommendations based on an exploratory analysis of respiratory syncytial virus reports derived from the European Influenza Surveillance System", BMC Infect Dis, 6, pp.128~ (2006)
- Lee JH, "Clinical manifestations of acute viral lower tract infections by multiplex RT- PCR", Programm and Abstract, the 56th Annual Fall Meeting of the Korean Pediatric Society; 2006 Oct 20-21; Seoul. : The Korean Pediatric Society, 218~ (2006)
- Roh EJ, "Comparison of multiplex PCR with viral cultures and immunofluorescent antigen detection for respiratory virus in hospitalized children", Pediatr Allergy Respir Dis (Korea), 14(1), pp.32~ (2007)
- Berman S, "Acute lower respiratory tract illnesses in Cali, Colombia: a two- year ambulatory study", Pediatrics, 71, pp.210~218 (1983)
- Berman S, "Epidemiology of acute respiratory infections in children of developing countries", Rev Infect Dis, 13(6), pp.454~462 (1991)
- Sunakorn P, "Epidemiology of acute respiratory infections in young children from Thailand", Pediatr Infect Dis J, 9, pp.873~877 (1990)
- Ruutu P, "Viral lower respiratory tract infections in Filipino children", J Infect Dis, 161, pp.175~179 (1990)
- Muller-Pebody B, "Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995- March 1998", Epidemiol Infect, 129, pp.99~106 (2002)
- Denny FW, "Croup: an 11-year study in a pediatric practice", Pediatrics, 71, pp.871~876 (1983)
- Lee HJ, "Viral etiology and epidemiology of acute lower respiratory tract infections in children", Korean J Infec Dis, 27, pp.319~332 (1995)
- Jeon NL, "Etiology and clinical features of severe acute viral lower respiratory tract infections in children", J Korean Pediatr Soc, 43, pp.1558~1568 (2000)
- Lee SY, "Epidemiology of childhoood viral respiratory tract infections in Seoul", Pediatr Allergy Respi Dis (Korea), 9, pp.100~108 (1999)
- Glezen WP, "Influenza virus infections in infants", Pediatr Infect Dis J, 16, pp.1065~1068 (1997)
- Chapman RS, "The epidemiology of tracheobronchitis in pediatric practice", Am J Epidemiol, 114, pp.786~797 (1981)
- Schanzer DL, "Hospitalization attributable to influenza and other viral respiratory illnesses in Canadian children", Pediatr Infect Dis J, 25, pp.795~800 (2006)
- Tseng RK, "Influenza virus infections in Taiwan from 1979 to 1995", Jpn J Med Sci Biol, 49, pp.77~93 (1996)
- Nah SY, "Epidemiology of influenza virus over 8 years (1990- 1998) in Seoul, Korea", Korean J Infec Dis, pp.21~216 (1999)
- Fry AM, "Seasonal trends of human parainfluenza viral infections: United States, 1990-2004", Clin Infect Dis, 43, pp.1016~1022 (2006)
- Brandt CD, "Infections in 18,000 infants and children in a controlled study of respiratory tract diseaseⅡ.Variation in adenovirus infections by year and season", Am J Epidemiol, 95, pp.218~227 (1972)
- Nah SY, "Etiology and clinical features of acute viral lower respiratory tract infection in apparently healthy children", J Korean Pediatr Soc, 39, pp.1690~1699 (1996)
- Pyo JW, "Adenoviral respiratory tract infections in children", Korean J Infec Dis, 28, pp.493~501 (1996)
