서울의 2008-2009년 가을, 겨울철에 유행한 소아의 하기도 호흡기 바이러스 병원체의 규명
Identification of Viral Pathogens for Lower Respiratory Tract Infection in Children at Seoul During Autumn and Winter Seasons of the Year of 2008-2009
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목적:서울 지역의 급성 호흡기 감염의 원인이 되는 바이러스를 분석하고 임상적 특징과 비교, 분석하였다. 방 법:2008년 9월부터 2009년 3월까지 3개 대학병원에 입원한 5세 미만의 소아의 급성하기도감염환자에서 418개의 비인두흡입검체를 채취하여, 14종 바이러스를 multiplex PCR을 통한 진단하였다. 바이러스 양성 환자의 임상정보를 병원별, 시기별로 분석하였다. 결과:418명이 분석되었고, 연령은 평균 16.4개월, 성별비는 1.36대 1이었다. 환자들 중 56.2%에서 바이러스 양성을 보였고, RSV (35%)가 가장 많이 검출된 바이러스였으며, 다음은 hRV (22%)였으며, HBoV, ADV, hMPV, PIV1, IFV, hCoV, PIV2, PIV3가 검출되었다. 양성검체 중 21.9%에서 동시감염이 있었다. 결론:바이러스의 지역별, 시기별 지속적인 감시가 필요하며, 급성호흡기질환을 보이는 소아의 진료에, 유행하는 바이러스의 특징을 고려해야 할 것이다.
Abstract
Purpose:The Purposes of this study are to identify the circulating etiologic viruses of acute lower respiratory tract infection in children and to understand the relation with clinical diagnosis. Methods:We obtained a total of 418 nasopharyngeal aspirates from children admitted for their acute lower respiratory tract infections at three tertiary hospitals in Seoul from September 2008 to March 2009. We performed multiplex RT-PCR to identify 14 etiologic viruses and analyzed their emerging patterns and clinical features. Results:Average age of patients was 16.4 months old and the ratio of male to female was 1.36. Viruses were detected in 56.2% of a total of 418 samples. Respiratory syncytial virus (35%) was the most frequently detected and followed by human rhinovirus (22%), human bocavirus, adenovirus, human metapneumovirus, parainfluenza virus, influenza virus and human coronavirus. Co-infection reached 21.9 % of positive patients. Conclusion:When we manage the patients with acute lower respiratory infectious diseases, we should remind the role of various viral pathogens, which might be circulating by seasons and by local areas.
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