ALDH2 유전자형에 따라 나이, 성별로 나누어 비교한 혈중 아세트알데히드 농도에 관한 연구
Comparison Study on the Blood Acetaldehyde Concentration According to ALDH2 Genotype, Age, Gender
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
ObjectivesZZAlcohol is metabolized to acetaldehyde by alcohol dehydrogenase enzyme in the liver and then acetaldehyde is metabolized to acetone by aldehyde dehydrogenase (ALDH) in the liver. There are two main ALDH enzymes which metabolize the acetaldehyde produced during ethanol oxidation. In particular, in the presence of the ALDH2 1*2 allele, the activity of the ALDH 2 enzyme is lowered. As a result, acetaldehyde metabolism is slowed down and acetaldehyde accumulates in the body compared to the ALDH2 1*1 allele. There are many studies that have investigated the blood acetaldehyde concentration according to the ALDH2 genotype, but there are few studies to compare this with age. So we investigated the blood acetaldehyde concentration according to ALDH2 genotype, age and gender. MethodsZZAccording to the ALDH2 genotype, we divided the group by gender and age. We divided the age group in to three groups which ranged from 20 to 34 years old, from 35 to 49 years old, and lastly from 50 to 64 years old. And then we collected blood samples after 15 min, 30 min, 1 hr, 2 hr, 3 hr, 4 hr, 5 hr and 15 hr of after drinking to measure the blood acetaldehyde concentration. ResultsZZIn ALDH2 1*2 allele group, there are significant differences of the blood acetaldehyde concentration between the age groups. In ALDH2 1*2 allele and male group, there are significant differences of the blood acetaldehyde concentration between the age groups. ConclusionsZZThere are significant differences of the blood acetaldehyde concentration between the age groups according to ALDH2 genotype. Also, there are significant differences of the blood acetaldehyde concentration between the age groups with male gender and ALDH2 1*2 allele. Studies about other factors that may influence the blood acetaldehyde concentration are needed.
Abstract
ObjectivesZZAlcohol is metabolized to acetaldehyde by alcohol dehydrogenase enzyme in the liver and then acetaldehyde is metabolized to acetone by aldehyde dehydrogenase (ALDH) in the liver. There are two main ALDH enzymes which metabolize the acetaldehyde produced during ethanol oxidation. In particular, in the presence of the ALDH2 1*2 allele, the activity of the ALDH 2 enzyme is lowered. As a result, acetaldehyde metabolism is slowed down and acetaldehyde accumulates in the body compared to the ALDH2 1*1 allele. There are many studies that have investigated the blood acetaldehyde concentration according to the ALDH2 genotype, but there are few studies to compare this with age. So we investigated the blood acetaldehyde concentration according to ALDH2 genotype, age and gender. MethodsZZAccording to the ALDH2 genotype, we divided the group by gender and age. We divided the age group in to three groups which ranged from 20 to 34 years old, from 35 to 49 years old, and lastly from 50 to 64 years old. And then we collected blood samples after 15 min, 30 min, 1 hr, 2 hr, 3 hr, 4 hr, 5 hr and 15 hr of after drinking to measure the blood acetaldehyde concentration. ResultsZZIn ALDH2 1*2 allele group, there are significant differences of the blood acetaldehyde concentration between the age groups. In ALDH2 1*2 allele and male group, there are significant differences of the blood acetaldehyde concentration between the age groups. ConclusionsZZThere are significant differences of the blood acetaldehyde concentration between the age groups according to ALDH2 genotype. Also, there are significant differences of the blood acetaldehyde concentration between the age groups with male gender and ALDH2 1*2 allele. Studies about other factors that may influence the blood acetaldehyde concentration are needed.
참고문헌 (26)
- Zakhari S, "Overview : how is alcohol metabolized by the body?", Alcohol Res Health, 29, pp.245~254 (2006)
- Quertemont E, "Role of acetaldehyde in mediating the pharmacological and behavioral effects of alcohol", Alcohol Res Health, 29, pp.258~265 (2006)
- Eriksson CJ, "The role of acetaldehyde in the actions of alcohol(update 2000)", Alcohol Clin Exp Res, 25(Suppl 1), pp.15S~32S (2001)
- Quertemont E, "The role of acetaldehyde in the neurobehavioral effects of ethanol : a comprehensive review of animal studies", Prog Neurobiol, 75, pp.247~274 (2005)
- Quertemont E, "Behavioral characterization of acetaldehyde in C57BL", 6J mice : locomotor, hypnotic, anxiolytic and amnesic effects, 2004, pp.177, 84~92
- Brown ZW, "Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats", Psychopharmacology(Berl), 64, pp.271~276 (1979)
- Rodd-Henricks ZA, "The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats", Pharmacol Biochem Behav, 72, pp.55~64 (2002)
- Belluzzi JD, "Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats", Neuropsychopharmacology, 30, pp.705~712 (2005)
- Foddai M, "Acetaldehyde increases dopaminergic neuronal activity in the VTA", Neuropsychopharmacology, 29, pp.530~536 (2004)
- Peng GS, "Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations", Hum Genomics, 3, pp.121~ (2009)
- Goedde HW, "Distribution of ADH2 and ALDH2 genotypes in different populations", Hum Genet, 88, pp.344~346 (1992)
- Mizoi Y, "Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese", Pharmacol Biochem Behav, 18(Suppl 1), pp.127~133 (1983)
- Wall TL, "A genetic association with the development of alcohol and other substance use behavior in Asian Americans", J Abnorm Psychol, 110, pp.173~178 (2001)
- Li TK, "Genetic and environmental influences on alcohol metabolism in humans", Alcohol Clin Exp Res, 25, pp.136~144 (2001)
- Kang TS, "Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups", J Clin Pharm Ther, 34, pp.225~230 (2009)
- Enomoto N, "Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes", Alcohol Clin Exp Res, 15, pp.141~144 (1991)
- Yokoyama A, "Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype", Alcohol Clin Exp Res, 32, pp.1607~1614 (2008)
- Collins AC, "Variations in alcohol metabolism : influence of sex and age", Pharmacol Biochem Behav, 3, pp.973~978 (1975)
- Meier P, "Age, alcohol metabolism and liver disease", Curr Opin Clin Nutr Metab Care, 11, pp.21~26 (2008)
- Matsuda T, "Increased DNA damage in ALDH2-deficient alcoholics", Chem Res Toxicol, 19, pp.1374~1378 (2006)
- Hashimoto T, "ALDH2 1510 G", A(Glu487Lys)polymorphism interaction with age in head and neck squamous cell carcinoma, 2006, pp.27, 334~338
- Shin CM, "Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotype in the Korean population", Int J Epidemiol, 40, pp.1047~1055 (2011)
- Kimura M, "Gender differences in the effects of ADH1B and ALDH2 polymorphisms on alcoholism", Alcohol Clin Exp Res, 35, pp.1923~1927 (2011)
- Kishimoto R, "Gender-related differences in mouse hepatic ethanol metabolism", J Nutr Sci Vitaminol(Tokyo), 48, pp.216~224 (2002)
- Mumenthaler MS, "Gender differences in moderate drinking effects", Alcohol Res Health, 23, pp.55~64 (1999)
- Zeiner AR, "Gender differences in peak acetaldehyde concentration after an acute dose of ethanol", Neurobehav Toxicol Teratol, 5, pp.201~204 (1983)