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천식 환자에서 집먼지진드기 감작 유무에 따른 임상적 차이: 순천향 코호트 분석

The differences of clinical profiles by house dust mite sensitization in patients with asthmatics in Soonchunhyang University Hospital cohort

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키워드

주제분류소아과학

초록

Purpose: The majority of patients with allergic disease are highly sensitized to house dust mites (HDM). There is few data to observe sensitization rate to HDM in asthmatics in Korea. The aim of this study was to observe the differences of clinical profiles by HDM sensitization in patients with asthmatics in Soonchunhyang University Hospital (SCH) cohort. Methods: We recruited 2,345 asthmatic patients in SCH cohort. Lung function, body mass index and sputum and blood eosinophils, and PC20, and clinical profiles were compared by HDM sensitization. Results: Dermatophagoides farinae (Derf) and/or Dermatophagoides pteronyssinus (Derp) (+) sensitization rate was higher prevalence in male than in female. Compared with nonatopy asthmatics, Derf and/or Derp (+) asthmatics had early onset of age [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 32.5±0.51 vs. 36.1±0.88 vs. 43.1±0.54, P<0.05]. Derf and/or Derp (+) asthmatics had shorter duration of asthma symptom than that of nonatopy asthmatics. Derf and/or Derp (+) asthmatics had lower forced expiratory volume in one second and forced vital capacity than those of Derf and Derp (-) asthmatics. PC20 in Derf and/or Derp (+) asthmatics had lower than those of Derf and Derp (-) and nonatopy asthmatics [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 5.4±0.24 mg/mL vs. 6.59±0.52 mg/mL vs. 7.19±0.33 mg/mL, P<0.05]. Blood eosinophils number in Derf and/or Derp (+) asthmatics had higher than that of nonatopy asthmatics (414.7±131.1 vs. 350.6±14.0, P<0.05). Total immunoglobulin E (IgE) in Derf and/or Derp positive asthmatics had higher than that of Derf and Derp negative and nonatopy asthmatics. There was no difference of body mass index among three groups. Conclusions: Our data indicate that atopy asthmatics sensitized to Derf and/or Derp had early onset of age, high total IgE and airway responsiveness, and eosinophilic inflammation.

Abstract

Purpose: The majority of patients with allergic disease are highly sensitized to house dust mites (HDM). There is few data to observe sensitization rate to HDM in asthmatics in Korea. The aim of this study was to observe the differences of clinical profiles by HDM sensitization in patients with asthmatics in Soonchunhyang University Hospital (SCH) cohort. Methods: We recruited 2,345 asthmatic patients in SCH cohort. Lung function, body mass index and sputum and blood eosinophils, and PC20, and clinical profiles were compared by HDM sensitization. Results: Dermatophagoides farinae (Derf) and/or Dermatophagoides pteronyssinus (Derp) (+) sensitization rate was higher prevalence in male than in female. Compared with nonatopy asthmatics, Derf and/or Derp (+) asthmatics had early onset of age [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 32.5±0.51 vs. 36.1±0.88 vs. 43.1±0.54, P<0.05]. Derf and/or Derp (+) asthmatics had shorter duration of asthma symptom than that of nonatopy asthmatics. Derf and/or Derp (+) asthmatics had lower forced expiratory volume in one second and forced vital capacity than those of Derf and Derp (-) asthmatics. PC20 in Derf and/or Derp (+) asthmatics had lower than those of Derf and Derp (-) and nonatopy asthmatics [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 5.4±0.24 mg/mL vs. 6.59±0.52 mg/mL vs. 7.19±0.33 mg/mL, P<0.05]. Blood eosinophils number in Derf and/or Derp (+) asthmatics had higher than that of nonatopy asthmatics (414.7±131.1 vs. 350.6±14.0, P<0.05). Total immunoglobulin E (IgE) in Derf and/or Derp positive asthmatics had higher than that of Derf and Derp negative and nonatopy asthmatics. There was no difference of body mass index among three groups. Conclusions: Our data indicate that atopy asthmatics sensitized to Derf and/or Derp had early onset of age, high total IgE and airway responsiveness, and eosinophilic inflammation.

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관련 논문AI추천

집먼지진드기에 대한 감작: 집먼지진드기에 감작된 젊은 천식 환자에서 기도과민성과의 연관성송우정, 이상민, 이지은, 이진국, 조상헌, 황세민대한천식알레르기학회 · 천식 및 알레르기2012 · 제32권 제3호정상 혈청 총 IgE치를 보이는 알레르기 천식환자의 임상적 특성김옥기, 신홍준, 이성지, 이우진, 정성훈, 정지민, 최인선, 한의령대한천식알레르기학회 · 천식 및 알레르기2009 · 제29권 제2호소아 아토피 천식 환자에서 실내 흡입 알레르겐 특이 IgE 농도와 총 IgE 농도 및 기도 과민성 사이의 연관성우성일, 임정숙, 한윤수대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2009 · 제19권 제1호성인 집먼지진드기 알레르기 환자에서 특이 IgE 결합 성분항원 비교남영희, 박해심, 안준홍, 윤문경, 정진홍, 진현정대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2016 · 제4권 제3호천식 환아에서 집먼지진드기 감작이 기도과민성과 폐기능에 미치는 영향김은옥, 박강서, 진소희대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2007 · 제17권 제4호천식 환아에서 집먼지진드기 항원 감작과기도과민성 및 폐기능과의 관계김봉성, 김자형, 김효빈, 서희정, 이소연, 홍수종대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2005 · 제15권 제4호

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