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한국인 주의력결핍 과잉행동장애와 세로토닌 1B 수용체 유전자 자형성의 관련성 : 가족기반 연구 및 환자-대조군 연구

A Family-Based and Case-Control Association Study

정영철|임명호|유희정|김붕년|박태원|강대희
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2004.11|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제11권 제2호|pp. 146-154

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키워드

주의력결핍 과잉행동장애·세로토닌·5HT -1B 수용체·G861C 다형성·관련연구.
주제분류정신과학

초록

Abstract

Attention deficit hyperactivity disorder(ADHD) is the most common childhood psychiatric disorder, affecting 3-5% of school-aged children. Although the biological basis of ADHD is unknown, family studies provide strong evidence that ADHD has a genetic basis. Recent genetic studies have suggested associations between ADHD and serotonin 1B(5HT1B) receptor gene G861C polymorphism . The aim of this study is to test for the association between ADHD and 5HT1B receptor gene G861C polymorphism in Korean population. Method：We processed DNA extraction and genotyping. 106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test(TDT) and haplotype-based haplotype relative risk (HHRR). And the ADHD children were compared with 212 age and gender matched normal controls. Results：There was no statistical difference of distributions between ADHD cases and controls. We did not observe any preferential transmission of alleles of 5HT1B receptor gene G861C polymorphism in ADHD.Conclusions：Though there is the possibility of failing to detect small genetic effects, our results show no evidence of an association between ADHD and 5HT1B receptor gene G861C polymorphism in the Korean population and indicate that it is unlikely that the 5HT1B receptor is implicated in the susceptibility to ADHD.

참고문헌 (37)

  1. 조수철, "파탄적 행동장애의 유병률에 대한연구", 5, pp.141~149 (1994)
  2. 조수철, "소아정신질환의 개념", pp.146~150 (1999), 서울대학교출판부
  3. Stevenson J, "Evidence for a genetic etiology in hyperactivityin children", 22, pp.337~344 (1992)
  4. Gjone H,, "Genetic influenceon parent reported attention related problems in a Norweigangeneral population twin study", 35, pp.588~595 (1996)
  5. Levy F,, "Attention deficit hyperactivity disorder: A category or a continuum?Genetic analysis of a large-scale twin study", 36, pp.737~744 (1997)
  6. Rhee SH,, "Sex differencesin genetic and environmental influences on DSMIII-R attention deficit hyperactivity disorder", 108, pp.24~41 (1999)
  7. Halperin JM, "Serotonin,aggression,and parenteral psychopathology in children with attention-deficit hyperactivity disorder", 36, pp.1391~1398 (1997)
  8. Halperin JM, "Age-related changes in theassociation between serotonergic function and aggressionin boys with ADHD", 41, pp.682~689 (1997)
  9. Lucki I, "The spectrum of behaviors influenced by serotonin", 44, pp.151~162 (1998)
  10. Puumala T, "Changes in activities of dopamineand serotonin systems in the frontal cortex underlie poor choice accuracy and impulsivity of rats in an attentiontask", 83, pp.489~499 (1998)
  11. Gainetdinov RR, "Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity", 28, pp.397~401 (1999)
  12. Quist JF, "Genetics of childhood disorders XXIII. ADHD, Part 7: the serotonin system.", 40, pp.253~256 (2001)
  13. Sun HF, "Association study of novel human serotonin5-HT(1B)polymorphism with alcohol dependencein Taiwanese Han", 51, pp.896~901 (2002)
  14. Huang YY, "Substance abusedisorder and major depression are associated with the human 5-HT1B receptor gene(HTR1B)G861C polymorphism", 28, pp.163~169 (2003)
  15. Arango V, "Genetics of the serotonergic system in suicidal behavior", 37, pp.375~386 (2003)
  16. Soyka M, "Association of 5-HT1B receptor gene and antisocial behavior in alcoholism", 111, pp.101~109 (2004)
  17. Fisher SE, "A genomewide scanfor loci involved in attention-deficit", hyperactivity disorder, 2002, pp.70, 1183~1196
  18. Brunner D, "Anxiety,motoractivation and maternal-infant interaction in 5HT1Bknockout mice", 113, pp.587~601 (1999)
  19. Rempel NL, "Serotonin 1Breceptor activation mimics behavioral effects of presynapticserotonin release", 8, pp.201~211 (1993)
  20. Barness NM, "A review of central 5-HT receptorsand their function", 38, pp.1083~1152 (1999)
  21. Levy FO, "Molecular cloning ofa human serotonin receptor(S12)with a pharmacological profile resembling that of the 5-HT1D subtype", 267, pp.7553~7562 (1992)
  22. Huang Y, "Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue", 21, pp.238~246 (1999)
  23. Cigler T,, "Novel and previously reportedsingle-nucleotide polymorphism in the human 5-HT (1B) receptor gene: no association with cocaine or alcoholabuse or dependence", 105, pp.489~497 (2001)
  24. Hasegawa Y, "Association of a polymorphism of the serotonin 1Breceptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2", 109, pp.513~521 (2002)
  25. Stefulj J, B, "Serotonin 1B(5HT-1B) receptor polymorphism(G861C) in suicide victims: association studies in German and Slavic population", 127B, pp.48~50 (2004)
  26. Hawi Z,, "Serotonergic system and attention deficit hyperactivity disorder(ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample", 7, pp.718~725 (2002)
  27. Quist JF,, "The serotonin 5-HT1B receptorgene and attention deficit hyperactivity disorder", 8, pp.98~102 (2003)
  28. Faraone SV, "Report from the 4th International Meetingof the Attention Deficit Hyperactivity Disorder Molecular Genetics Network", 121B, pp.55~59 (2003)
  29. Sattler JM, "Assessment of children" (1992)
  30. Spielman RS, "Transmissiontest for linkage disequilibrium:the insulin gene regionand insulin-dependent diabetes mellitus(IDDM)", 52, pp.506~516 (1993)
  31. Terwilliger JD, "A haplotype-based “haplotyperelativerisk” approach to detecting allelic associations", 42, pp.337~346 (1992)
  32. Schaid DJ, "Genotype relative risk:methodsfor design and analysis of candidate-gene associationstudies", 53, pp.1114~1126 (1995)
  33. Ewens WJ, "The transmission", disequilibriumtest: history,subdivision,and admixture, 1995, pp.57, 455~464
  34. Spielman RS, "The TDT and other familybasedtests for linkage disequilibrium and association", 59, pp.983~989 (1996)
  35. Nishiguchi N, "No evidence of an associationbetween 5HT1B receptor gene polymorphismand suicide victims in Japanese population", 105, pp.343~345 (2001)
  36. Halperin JM, "Serotonergic function inaggressive and nonaggressive boy with attention deficithyperactivity disorder", 152, pp.243~248 (1994)
  37. Castellanos FX,, "Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivitydisorder", 52, pp.305~316 (1995)

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