정신분열병의 선택적 주의력 저하의 보상 기전
Compensatory Neural Correlates of Selective Attention Deficit in Schizophrenics Showing Normal Accuracy during Stroop
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참고문헌
키워드
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Abstract
Objectives：This study investigated the compensatory neural correlate of selective attention deficit in schizophrenics showing near-normal performance. Methods：A ‘modified Stroop’ was developed that can be used measure the response time during functional imaging. An event-related functional magnetic resonance imaging study was carried out in 10 clinically stabilized schizophrenics and 10 healthy controls during the performance of a ‘modified Stroop’. In the ‘modified Stroop’, the subjects were required to respond with a two-button mouse to whether or not the color of a subsequent word corresponded to one of T-shirt. The significantly activated brain regions were investigated in a voxel-wise t-test of the Stroop load. Results：Schizophrenics, compared with healthy controls, showed poorer response time, but had similar accuracy. Compensatory activation in the right inferior frontal gyrus (IFG) was observed in schizophrenics. The left paracingulate sulcus was less activated in the schizophrenics than in the healthy controls. Conclusion：These results suggest that, in schizophrenics showing a normal accuracy during the Stroop, selective attention deficits might be related to the left paracingulate sulcus as well as the anterior cingulate. In addition, their deficits may be compensated with the right IFG. (J Korean Neuropsychiatr Assoc 2004;43(6):674-680)
참고문헌 (26)
- "What is the nature ofincreased Stroop interference in schizophrenia?", 101, pp.3~25 (1999)
- "Neurocognitive functioning in patients withschizophrenia: an overview", pp.1245~1257 (1995)
- "Information processing and attention dysfunctions inschizophrenia", 19, pp.233~259 (1993)
- H2O PET study during single-trial Stroop task performance, , 1997, 1670~1675
- "Anterior cingulate activation during Stroop task performance:aPET to MRI coregistration study of individual patients with schizophrenia", 159, pp.251~254 (2002)
- , 1992, 435~443
- "Role of the human anteriorcingulate cortex in the control of occulomotor,manual,and speechresponses:A positron emission tomography study", 70, pp.453~469 (1993)
- "Contributions of anterior cingulatecortex to behaviour", 118, pp.279~306 (1995)
- "Anterior cingulate metabolism correlates with stroop errors in paranoidschizophrenia patients", 25, pp.139~148 (2001)
- "Dissociatingthe role of the dorsolateral prefrontal and anterior cingulate cortex incognitive control", 288, pp.1835~1838 (2000)
- "Anevent-related functional MRI study of the Stroop color word interferencetask", 10, pp.552~560 (2000)
- "The counting stroop:An interference task specialized for functionalneuroimaging-Validation study with functional MRI", 6, pp.270~282 (1998)
- "The assessment and analysis of handedness:The Edinburghinventory", 9, pp.97~113 (1971)
- "Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia", 58, pp.280~288 (2001)
- "Improved assessment of significant activation in functional magneticresonance imaging(fMRI)use of a cluster-size threshold", 33, pp.636~647 (1995)
- "Blunted left cingulate activation in mood disorder subjectsduring a response interference task(the Stroop)", 9, pp.55~63 (1997)
- "Color-word matchingStroop task:separating interference and response conflict", 13, pp.29~36 (2001)
- "Cerebral gray and white matter reductions and clinicalcorrelates in patients with early onset schizophrenia", 50, pp.19~26 (2001)
- "Structural abnormalities in frontal,temporal,and limbic regions and interconnecting white matter tracts in schizophrenicpatients with prominent negative symptoms", 158, pp.234~243 (2001)
- "Model generation and testing to probe neural circuitry inthe cingulate cortex of postmortem schizophrenic brain", 242, pp.219~230 (1998)
- "Effects of age,medication,and illness duration on the N-acetylaspartate signal of the anterior cingulate region in schizophrenia", 41, pp.389~395 (2000)
- "Response selection in the human anterior cingulatecortex", 2, pp.920~924 (1999)
- "Event-related fMRI study of responseinhibition.Hum", 12, pp.100~109 (2001)
- "Brain activation patterns during a selective attentiontest-a functional MRI study in healthy volunteers and patientswith schizophrenia", 123, pp.1~15 (2003)
- "Functional anatomy of GO", NO-GO discrimination and responseselection-A PET study in man, 1996, pp.728, 79~89
- "Differences in frontal cortical activation by a workingmemory task after substitution of risperidone for typical antipsychoticdrugs in patients with schizophrenia", 96, pp.13432~13437 (1999)