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정신분열병 환자의 작동기억 이상에 대한 기능적 자기공명영상 연구

Working Memory Deficits in Patients with Schizophrenia : fMRI Investigation

김정진|이수정|이철|김태석|이창욱|배치운|백인호|박여진|노사봉
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2005.06|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제12권 제1호|pp. 32-41

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참고문헌

키워드

정신분열병·작동기억·기능자기공명영상.Schizophrenia·Working memory·fMRI.
주제분류정신과학

초록

Abstract

objective：Impaired processing of working memory is one of the cognitive deficits seen in patients with schizophrenia. This aimed at corroborating the differences in the brain activities involved in the process of working memory between patients with schizophrenia and the control subjects. Method：Fourteen patients with schizophrenia and 12 healthy volunteers were recruited in this study. Functional magnetic resonance imaging(fMRI) was used to assess cortical activities during the performance of a 2-back visual working memory paradigm using the Korean alphabet as mnemonic content. Results：Group analysis revealed that left lateral prefrontal cortex and right parietal lobule showed decreased cortical activities in the patient group. On the other hand, an increased activation in left superior and middle frontal gyrus, left middle temporal gyrus, right cuneus, both occipital lobes, right fusiform gyrus and right cingulate gyrus. The activation in left anterior lobe and both declive of cerebellum was also increased. Conclusions：This study showed a decreased activation in left lateral prefrontal and right parietal neural networks from the patient group and confirmed the earlier findings on the impaired working memory of patients with schizophrenia using fMRI investigation. The regions implicated in our study suggest an abnormal functioning of the fronto-parietal cortical areas that are critical to the information processing stream, which might be correspondent to common pathophysiology rather than a common etiology in schizophrenia.

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