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정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

Working Memory Dificits of Facial Images in Patients with Schizophrenia : fMRI Investigation

김정진|이수정|박여진|이철|김태석|김종진|배치운|백인호|박주미|전신수|이창욱|주라형
대한신경정신의학회 (Korean Neuropsychiatric Association)|2005.03|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제44권 제2호|pp. 198-206

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참고문헌

주제분류정신과학

초록

Abstract

Objectives：Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with schizophrenia.We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods：Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the performance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Results：The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the parietal lobule was observed from the patient group, all in the right hemisphere. Conclusion：A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

참고문헌 (58)

  1. "Emotion recognition via facial expressionand affective prosody in schizophrenia:a methodologicalreview", 22, pp.789~832 (2002)
  2. "A compensatorymirror cortical mechanism for facial affect processing inschizophrenia", 25, pp.915~924 (2001)
  3. "Implications forthe neural basis of social cognition for the study of schizophrenia", 160, pp.815~824 (2003)
  4. "Impairmentin basal limbic function in schizophrenia during affect recognition", 122, pp.115~124 (2003)
  5. "A fMRI study of facial emotion processing in patients with schizophrenia", 159, pp.1992~1999 (2002)
  6. "Structural and functionalabnormalities of the amygdala in schizophrenia", 985, pp.445~460 (2003)
  7. "Nosing in on the emotional brain", 6, pp.106~108 (2003)
  8. "Facial affect recognition in pre-lingually deaf people with schizophrenia", 61, pp.265~270 (2003)
  9. "Neurons in the cortex of the temporal lobe and in the amygdalaof the monkey with responses selective for faces", 3, pp.209~222
  10. "Perceptualand semantic components of memory for objects and faces:a PETstudy", 13, pp.430~443 (2001)
  11. "Direct comparison of the neural substrates of recognition memoryfor words and faces", 122, pp.1069~1083 (1999)
  12. "Visual imagery of famous faces:effects of memory and attention revealed by fMRI", 17, pp.1729~1741 (2002)
  13. "Schizophreniaand temporal lobe asymmetry:A post-mortem stereologicalstudy of tissue volume", 175, pp.127~134 (1999)
  14. "Anomalous asymmetry of fusiform and parahippocampalgyrus gray matter in schizophrenia:A postmortem study", 157, pp.40~44 (2000)
  15. "Fusiform gyrus volume reduction in first-episode schizophrenia:a magnetic resonance imaging study", 59, pp.775~781 (2002)
  16. "Fusiform gyrus volume reduction and facial recognition in chronicschizophrenia", 60, pp.349~355 (2003)
  17. "Recognitionmemory for faces in schizophrenia patients and their firstdegreerelatives", 40, pp.2314~2324 (2002)
  18. "Advances in the neuroimaging of cognitive functionsin schizophrenia", 15, pp.3~7 (2002)
  19. "Working memoryand prefrontal cortex dysfunction:specificity to schizophrenia comparedwith major depression", 53, pp.376~384 (2003)
  20. "The neural basis of the central executive system of working memory", 378, pp.279~281 (1995)
  21. "Dissociating working memory from task difficulty in human prefrontalcortex", 35, pp.1373~1380 (1997)
  22. "Concurrent performance of two working memory tasks potential mechanisms of interference", 8, pp.593~601 (1998)
  23. "Language comprehension andworking memory language comprehension and working memory deficitsin patients with schizophrenia", 60, pp.299~309 (2003)
  24. "No hypofrontality,but absence of prefrontal lateralizationcomparing verbal and spatial working memory in schizophrenia", 61, pp.175~184 (2003)
  25. "The Brief Psychiatric Rating Scale", 10, pp.799~812 (1962)
  26. "a practicalmethod for grading the cognitive state of patients for the clinician"
  27. "Two Factor Index of Social Position" (1965), Yale University Press
  28. "Raven’s Progressive Matrices and VocabularyScale" (1995), Oxford Psychologists Pres
  29. "From few to many illumination cone models for face recognition under variable lightingand pose", 23, pp.643~660 (2001)
  30. "Testing for a signal with unknown location and scale in astationary Gaussian random field", 23, pp.608~639 (1995)
  31. "Analysis of fMRI time-series revisited", 2, pp.45~53 (1995)
  32. "Co-planar Stereotaxic Atlas of the HumanBrain" (1988), Thieme,New York
  33. "How many subjects constitute astudy", 10, pp.1~5 (1999)
  34. "Mapping of gray matter changes in schizophrenia", 35, pp.1~14
  35. "Cerebral metabolic patterns in chronic and recent-onset schizophrenia", 122, pp.125~135 (2003)
  36. "Akinesia:a syndrome common to parkinsonism,retarded depression,and negative symptoms of schizophrenia", 33, pp.221~232 (1992)
  37. "Comparison of the effects of risperidone and haloperidolon regional cerebral blood flow in schizophrenia", 49, pp.704~715 (2001)
  38. "Cerebralmetabolism and risperidone treatment in schizophrenia", 60, pp.1~7 (2003)
  39. "Attentional activationof the cerebellum independent of motor involvement", 275, pp.1940~1943 (1997)
  40. "Prediction and preparation,fundamental functionsof the cerebellum", 4, pp.1~35 (1997)
  41. "Workingmemory for visual features and conjunctions in schizophrenia", 112, pp.61~71 (2003)
  42. "Evidence for altered cerebellarvermis neuronal integrity in schizophrenia", 107, pp.125~134 (2001)
  43. "Selective reduction of the posterior superior vermis inmen with chronic schizophrenia", 55, pp.61~67 (2002)
  44. "Schizophrenic subjects activate dorsolateral prefrontal cortex duringa working memory task,as measured by fMRI", 45, pp.1128~1137 (1999)
  45. "Schizophrenic subjects show aberrant fMRI activation of dorsolateralprefrontal cortex and basal ganglia during working memoryperformance", 48, pp.99~109 (2000)
  46. "Physiological dysfunction of the dorsolateral prefrontal cortex inschizophrenia revisited", 10, pp.1078~1092 (2000)
  47. "Abnormal fMRI response of the dorsolateral prefrontal cortexin cognitively intact siblings of patients with schizophrenia", 160, pp.709~719 (2003)
  48. "Functional MRI studies of spatial and nonspatial working memory", 7, pp.1~13 (1998)
  49. "Prefrontal-posterior parietal networks in schizophrenia:primarydysfunctions and secondary compensations", 53, pp.12~24 (2003)
  50. "Brain imaging of the central executivecomponent of working memory", 26, pp.105~125 (2002)
  51. "The role of theanterior prefrontal cortex in human cognition", 399, pp.148~151 (1999)
  52. "Working memory deficits and levels of N-acetylaspartate in patientswith schizophreniform disorder", 160, pp.483~489 (2003)
  53. "Rightlateral fusiform gyrus dysfunction during facial information processingin schizophrenia", 53, pp.1099~1112 (2003)
  54. "Laterality in functional brain imaging studies of schizophrenia", 25, pp.141~156 (1999)
  55. "Schizophrenia as the price that homo sapiens pays for language:a resolution of the central paradox in the origin of the species", 31, pp.118~129 (2000)
  56. "Thefunctional roles of prefrontal cortex in episodic memory", 121, pp.1249~1256 (1998)
  57. "Dissociating verbal and spatialworking memory using PET", 6, pp.11~20 (1996)
  58. "Human prefrontalcortex is not specific for working memory:a functional MRI study", 8, pp.274~282 (1998)

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