소아 급성특발성두드러기에서 성분 항원에 대한 감작
Sensitization to component antigens in acute idiopathic urticaria in children
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Purpose: The aim of this study was to evaluate hidden allergens of acute idiopathic urticaria (AIU) in childhood by using the component-resolved diagnostics (CRD). Methods: We applied CRD using pathogenesis-related protein family number 10 (PR-10) and nonspecific lipid transfer proteins (nsLTP). Results: Twenty-two of the 74 AIU children (29.7%) were found to be positive on CRD. Ten children were positive to nMal d 1 for apple (value range, 1.10–40.59), 6 to rConr a 1 for hazelnut (1.53–11.97), 4 to rPru p 1 for peach (1.32–11.83). 6 to rAra h 8 for peanut (1.20–8.12), 6 to nAct d 8 for kiwi (0.85–3.32), 4 to rBet v 1 for birch (2.49–54.28), and 3 to rAln g 1 for alder (2.32–5.74). Six children were positive to nPru p 3 for peach (1.45–18.77), 4 to rCor a 8 for hazelnut (2.56–9.19), 2 to nArt v 3 for mugwort (3.40–7.42), and 3 to rBet v2 to profilin of birch (2.56–17.46). Ten children with AIU were positive to multiple component proteins. For hazelnut, 5 children were positive to PR-10 (rConr a 1) and nsLTP (rConr a 1). For peach, 3 children were positive to PR-10 (rPru p 1) and nsLTP (nPru p 3).
Abstract
Purpose: The aim of this study was to evaluate hidden allergens of acute idiopathic urticaria (AIU) in childhood by using the component-resolved diagnostics (CRD). Methods: We applied CRD using pathogenesis-related protein family number 10 (PR-10) and nonspecific lipid transfer proteins (nsLTP). Results: Twenty-two of the 74 AIU children (29.7%) were found to be positive on CRD. Ten children were positive to nMal d 1 for apple (value range, 1.10–40.59), 6 to rConr a 1 for hazelnut (1.53–11.97), 4 to rPru p 1 for peach (1.32–11.83). 6 to rAra h 8 for peanut (1.20–8.12), 6 to nAct d 8 for kiwi (0.85–3.32), 4 to rBet v 1 for birch (2.49–54.28), and 3 to rAln g 1 for alder (2.32–5.74). Six children were positive to nPru p 3 for peach (1.45–18.77), 4 to rCor a 8 for hazelnut (2.56–9.19), 2 to nArt v 3 for mugwort (3.40–7.42), and 3 to rBet v2 to profilin of birch (2.56–17.46). Ten children with AIU were positive to multiple component proteins. For hazelnut, 5 children were positive to PR-10 (rConr a 1) and nsLTP (rConr a 1). For peach, 3 children were positive to PR-10 (rPru p 1) and nsLTP (nPru p 3).
참고문헌 (26)
- Tuncel T, "Pediatricians' approach to children with acute urticaria", Minerva Pediatr, 68, pp.96~102 (2016)
- Carr TF, "Chapter 21: urticaria and angioedema", Allergy Asthma Proc, 33(Suppl 1), pp.S70~S72 (2012)
- Steele C, "Diagnosis of immediate food allergy", BMJ, 349, pp.g3695~ (2014)
- Valenta R, "Recombinant allergens for immunoblot diagnosis of tree-pollen allergy", J Allergy Clin Immunol, 88, pp.889~894 (1991)
- Thomas WR, "Cloning and expression of DNA coding for the major house dust mite allergen Der p 1 in Escherichia coli", Int Arch Allergy Appl Immunol, 85, pp.127~129 (1988)
- Valenta R, "Diagnosis of grass pollen allergy with recombinant timothy grass (Phleum pratense) pollen allergens", Int Arch Allergy Immunol, 97, pp.287~294 (1992)
- Valenta R, "Recombinant allergen molecules: tools to study effector cell activation", Immunol Rev, 179, pp.119~127 (2001)
- Canonica GW, "A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics", World Allergy Organ J, 6, pp.17~ (2013)
- Sastre J, "Molecular diagnosis in allergy", Clin Exp Allergy, 40, pp.1442~1460 (2010)
- Valenta R, "The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT)", Clin Exp Allergy, 29, pp.896~904 (1999)
- Wang J, "Correlation of IgE", IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy, 2010, pp.125, 695~702
- Melioli G, "The added value of allergen microarray technique to the management of poly-sensitized allergic patients", Curr Opin Allergy Clin Immunol, 12, pp.434~439 (2012)
- Ruiz-García M, "Profilin: a relevant aeroallergen?", J Allergy Clin Immunol, 128, pp.416~418 (2011)
- Hauser M, "Panallergens and their impact on the allergic patient", Allergy Asthma Clin Immunol, 6, pp.1~ (2010)
- Sastre J, "How molecular diagnosis can change allergen-specific immunotherapy prescription in a complex pollen area", Allergy, 67, pp.709~711 (2012)
- Tripodi S, "Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: implications for specific immunotherapy", J Allergy Clin Immunol, 129, pp.834~839 (2012)
- Nicolaou N, "Molecular diagnosis of peanut and legume allergy", Curr Opin Allergy Clin Immunol, 11, pp.222~228 (2011)
- Shreffler WG, "Microarrayed recombinant allergens for diagnostic testing", J Allergy Clin Immunol, 127, pp.843~849 (2011)
- Borres MP, "Use of allergen components begins a new era in pediatric allergology", Pediatr Allergy Immunol, 22, pp.454~461 (2011)
- Eigenmann PA, "Component-resolved diagnosis in food allergy, are micro-array assays helpful to the clinician?", Allergy, 63, pp.1519~1520 (2008)
- Mittermann I, "Recombinant allergen-based IgE testing to distinguish bee and wasp allergy", J Allergy Clin Immunol, 125, pp.1300~1307 (2010)
- Müller U, "IgE to recombinant allergens Api m 1, Ves v 1, and Ves v 5 distinguish double sensitization from crossreaction in venom allergy", Allergy, 67, pp.1069~1073 (2012)
- Walsh J, "Diagnosis and assessment of food allergy in children and young people in primary care and community settings: NICE clinical guideline", Br J Gen Pract, 61, pp.473~475 (2011)
- Vereda A, "Peanut allergy: clinical and immunologic differences among patients from 3 different geographic regions", J Allergy Clin Immunol, 127, pp.603~607 (2011)
- Luengo O, "Component resolved diagnosis: when should it be used?", Clin Transl Allergy, 4, pp.28~ (2014)
- Valenta R, "From allergen genes to allergy vaccines", Annu Rev Immunol, 28, pp.211~241 (2010)