소아 키위 과일 알레르기 환자에서 성분 항원 진단의 효용성
Additional diagnostic value of component resolved diagnosis in children with kiwifruit allergy
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: In food allergy, significant component antigens can be assessed by using the microarray. The purpose of this study was to evaluate the diagnostic value of component resolved diagnosis (CRD) in young children with kiwifruit allergy. Methods: Through a retrospective review of medical records, we evaluated the clinical characteristics of 12 children who underwent measurement of serum immunoglobulin E concentrations to kiwifruit (kiwi-sigE) and were diagnosed as kiwifruit allergy. We applied ImmunoCAP ISAC-CRD 112 using the residual sera of patients at the initial visit. Results: The median age of kiwifruit allergic children was 33.5 months (range, 13 to 84 months), and the proportion of systemic reactions, including 2 anaphylaxis cases, was 66.7%. Four had localized reactions on the lips. A total of 11 (91.7%) were sensitized to Act d 1; among them, 8 were mono-sensitized to Act d 1 and 3 were sensitized to ≥2 kiwifruit components. There was no significant difference in CRD results between those with systemic reactions and those with local reactions. Conclusion: Act d 1 is the major allergenic component in Korean young children with clinical kiwifruit allergy. The additional diagnostic value of the CRD in diagnosing and predicting the severity of kiwifruit allergy is expected to be low in young children.
Abstract
Purpose: In food allergy, significant component antigens can be assessed by using the microarray. The purpose of this study was to evaluate the diagnostic value of component resolved diagnosis (CRD) in young children with kiwifruit allergy. Methods: Through a retrospective review of medical records, we evaluated the clinical characteristics of 12 children who underwent measurement of serum immunoglobulin E concentrations to kiwifruit (kiwi-sigE) and were diagnosed as kiwifruit allergy. We applied ImmunoCAP ISAC-CRD 112 using the residual sera of patients at the initial visit. Results: The median age of kiwifruit allergic children was 33.5 months (range, 13 to 84 months), and the proportion of systemic reactions, including 2 anaphylaxis cases, was 66.7%. Four had localized reactions on the lips. A total of 11 (91.7%) were sensitized to Act d 1; among them, 8 were mono-sensitized to Act d 1 and 3 were sensitized to ≥2 kiwifruit components. There was no significant difference in CRD results between those with systemic reactions and those with local reactions. Conclusion: Act d 1 is the major allergenic component in Korean young children with clinical kiwifruit allergy. The additional diagnostic value of the CRD in diagnosing and predicting the severity of kiwifruit allergy is expected to be low in young children.
참고문헌 (13)
- 정경욱, "Age- Based Causes and Clinical Characteristics of Immediate-Type Food Allergy in Korean Children", Allergy, Asthma & Immunology Research, 9(5), pp.423~430 (2017), 대한천식알레르기학회
- Lucas JS, "Kiwi fruit allergy : a review", Pediatr Allergy Immunol, 14, pp.420~428 (2003)
- 이정민, "소아 키위 알레르기의 임상 특성과 특이 immunoglobulin E 항체의 유용성", Allergy Asthma & Respiratory Disease, 1(1), pp.73~78 (2013), 대한 소아알레르기 호흡기학회
- 최원복, "자작나무에 감작된 소아에서 과일 알레르기를 진단하기 위한 microarray법에 의한 성분 항원검사", Allergy Asthma & Respiratory Disease, 3(3), pp.200~205 (2015), 대한 소아알레르기 호흡기학회
- 이상철, "잡초류 감작에 의한 성인 구강알레르기증후군 2예", Allergy Asthma & Respiratory Disease, 4(6), pp.458~461 (2016), 대한 소아알레르기 호흡기학회[DOI]
- Matricardi PM, "EAACI molecular allergology user's guide", Pediatr Allergy Immunol, 27(Suppl 23), pp.1~250 (2016)
- Tosca MA, "Kiwifruit anaphylaxis : the usefulness of molecular-based allergy diagnostics", J Investig Allergol Clin Immunol, 25, pp.227~229 (2015)
- Le TM, "Kiwifruit allergy across Europe : clinical manifestation and IgE recognition patterns to kiwifruit allergens", J Allergy Clin Immunol, 131, pp.164~171 (2013)
- Moreno Álvarez A, "Kiwifruit allergy in children : characterization of main allergens and patterns of recognition", Children(Basel), 2, pp.424~438 (2015)
- Wang J, "A comprehensive review on kiwifruit allergy : pathogenesis, diagnosis, management, and potential modification of allergens through processing", Compr Rev Food Sci Food Saf, 18, pp.500~513 (2019)
- Asaumi T, "Negative Act d 8 indicates systemic kiwifruit allergy among kiwifruit-sensitized children", Pediatr Allergy Immunol, 28, pp.291~294 (2017)
- Sirvent S, "Detailed characterization of Act d 12 and Act d 13 from kiwi seeds : implication in IgE cross-reactivity with peanut and tree nuts", Allergy, 69, pp.1481~1488 (2014)
- Nucera E, "The clinical meaning of positive latex sIgE in patients with food", pollen adverse reactions, 2012, pp.25, 445~453