소아 구강알레르기증후군의 원인과 임상 특성
Etiology and clinical feature of oral allergy syndrome in children
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Purpose: Oral allergy syndrome (OAS) is a unique allergic reaction to fresh fruits or vegetables, which is caused by cross-reactivity between foods and pollens. This study was conducted to investigate the clinical feature of OAS and relevant pollen allergens as well as the association between them in Korean children. Methods: This single-center study included 290 children who were sensitized to pollens at Severance Hospital, and the clinical characteristics of children with and without OAS were compared. A multicenter study included 97 children who were diagnosed with OAS at 3 hospitals between January 2008 and June 2014. The details of clinical features were collected by retrospective medical record reviews using a standardized case report form. The relevant pollen allergens were identified by skin prick tests and/or serum specific IgE levels. Results: The most commonly sensitized allergen was Japanese hop in pollen-sensitized children. Children with OAS were most commonly sensitized to birch and oak, and 12.4% of the pollen-sensitized children had OAS in the single center. The number of children who were newly diagnosed with OAS has increased over the past 7 years. The most common causative food of OAS was apple. More than 60% of patients with OAS had oral allergic reactions to multiple foods. Conclusion: OAS may be relatively common in pollen-sensitized children. OAS should be considered in children with allergic disease and sensitization to pollens.
Abstract
Purpose: Oral allergy syndrome (OAS) is a unique allergic reaction to fresh fruits or vegetables, which is caused by cross-reactivity between foods and pollens. This study was conducted to investigate the clinical feature of OAS and relevant pollen allergens as well as the association between them in Korean children. Methods: This single-center study included 290 children who were sensitized to pollens at Severance Hospital, and the clinical characteristics of children with and without OAS were compared. A multicenter study included 97 children who were diagnosed with OAS at 3 hospitals between January 2008 and June 2014. The details of clinical features were collected by retrospective medical record reviews using a standardized case report form. The relevant pollen allergens were identified by skin prick tests and/or serum specific IgE levels. Results: The most commonly sensitized allergen was Japanese hop in pollen-sensitized children. Children with OAS were most commonly sensitized to birch and oak, and 12.4% of the pollen-sensitized children had OAS in the single center. The number of children who were newly diagnosed with OAS has increased over the past 7 years. The most common causative food of OAS was apple. More than 60% of patients with OAS had oral allergic reactions to multiple foods. Conclusion: OAS may be relatively common in pollen-sensitized children. OAS should be considered in children with allergic disease and sensitization to pollens.
참고문헌 (31)
- Mari A, "The oral allergy syndrome: improved diagnostic and treatment methods", Curr Opin Allergy Clin Immunol, 5, pp.267~273 (2005)[DOI]
- Yagami T, "Digestibility of allergens extracted from natural rubber latex and vegetable foods", J Allergy Clin Immunol, 106, pp.752~762 (2000)[DOI]
- Ma S, "A survey on the management of pollen-food allergy syndrome in allergy practices", J Allergy Clin Immunol, 112, pp.784~788 (2003)[DOI]
- Katelaris CH, "Food allergy and oral allergy or pollen-food syndrome", Curr Opin Allergy Clin Immunol, 10, pp.246~251 (2010)[DOI]
- Hoffmann-Sommergruber K, "Molecular characterization of Dau c 1, the Bet v 1 homologous protein from carrot and its cross-reactivity with Bet v 1 and Api g 1", Clin Exp Allergy, 29, pp.840~847 (1999)[DOI]
- Brown CE, "The prevalence of the oral allergy syndrome and pollen-food syndrome in an atopic paediatric population in south-west Sydney", J Paediatr Child Health, 50, pp.795~800 (2014)[DOI]
- Bedolla-Barajas M, "Prevalence of oral allergy syndrome in children with allergic diseases", Allergol Immunopathol (Madr), 45, pp.127~133 (2017)[DOI]
- Cho YS, "Oral allergy syndrome in pollen - sensitized patients", J Asthma Allergy Clin Immunol, 18, pp.458~465 (1998)
- Dreborg S, "Food allergy in pollen-sensitive patients", Ann Allergy, 61(6 Pt 2), pp.41~46 (1988)
- 박혜정, "A Six-Year Study on the Changes in Airborne Pollen Counts and Skin Positivity Rates in Korea: 2008–2013", Yonsei Medical Journal, 57(3), pp.714~720 (2016), 연세대학교의과대학[DOI]
- 김주화, "Changes in Sensitization Rate to Weed Allergens in Children with Increased Weeds Pollen Counts in Seoul Metropolitan Area", Journal of Korean Medical Science, 27(4), pp.350~355 (2012), 대한의학회[DOI]
- Webber CM, "Oral allergy syndrome: a clinical, diagnostic, and therapeutic challenge", Ann Allergy Asthma Immunol, 104, pp.101~108 (2010)[DOI]
- Yun YY, "IgE immune response to Ginkgo biloba pollen", Ann Allergy Asthma Immunol, 85, pp.298~302 (2000)[DOI]
- Bousquet J, "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)", Allergy, 63(Suppl 86), pp.8~160 (2008)[DOI]
- Crapo RO, "Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999", Am J Respir Crit Care Med, 161, pp.309~329 (2000)[DOI]
- Williams H, "Is eczema really on the increase worldwide?", J Allergy Clin Immunol, 121, pp.947~954 (2008)[DOI]
- 최민환, "학동전기 소아에서 흡입항원에의 감작과 알레르기질환과의 연관성", 천식 및 알레르기, 32(3), pp.176~182 (2012), 대한천식알레르기학회
- 이진우, "1999년, 2005년, 2008년 피부반응검사 분석을 통해 본 지난 10년간 경기 남부지역 대학병원에 내원한 알레르기 환자의 화분 알레르겐 감작률의 변화", 천식 및 알레르기, 31(1), pp.33~40 (2011), 대한천식알레르기학회
- 진현정, "The Allergenic Potency of Japanese Hop Pollen Is Increasing With Environmental Changes in Korea", Allergy, Asthma & Immunology Research, 5(5), pp.309~314 (2013), 대한천식알레르기학회
- Caliskaner Z, "Risk factors for oral allergy syndrome in patients with seasonal allergic rhinitis", Med Oral Patol Oral Cir Bucal, 16, pp.e312~e316 (2011)
- Ludman S, "Pollen food syndrome amongst children with seasonal allergic rhinitis attending allergy clinic", Pediatr Allergy Immunol, 27, pp.134~140 (2016)[DOI]
- American College of Allergy, "Food allergy: a practice parameter", Ann Allergy Asthma Immunol, 96(3 Suppl 2), pp.S1~S68 (2006)
- Kondo Y, "Oral allergy syndrome", Allergol Int, 58, pp.485~491 (2009)[DOI]
- Mogensen JE, "The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands", J Biol Chem, 277, pp.23684~23692 (2002)[DOI]
- Asero R, "EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multi-centre study", Clin Exp Allergy, 39, pp.547~555 (2009)[DOI]
- Kondo Y, "Assessment of cross-reactivity between Japanese cedar (Cryptomeria japonica) pollen and tomato fruit extracts by RAST inhibition and immunoblot inhibition", Clin Exp Allergy, 32, pp.590~594 (2002)[DOI]
- Maeda N, "Correlation of oral allergy syndrome due to plant-derived foods with pollen sensitization in Japan", Ann Allergy Asthma Immunol, 104, pp.205~210 (2010)[DOI]
- Cuesta-Herranz J, "Allergy to plant-derived fresh foods in a birch- and ragweed-free area", Clin Exp Allergy, 30, pp.1411~1416 (2000)[DOI]
- Egger M, "Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view", Allergy, 61, pp.461~476 (2006)[DOI]
- 홍가나, "쑥갓 및 깻잎에 의한 구강 알레르기증후군 1예", Allergy Asthma & Respiratory Disease, 2(4), pp.306~309 (2014), 대한 소아알레르기 호흡기학회
- 이근호, "면역치료로 치유된 구강 알레르기 증후군 1예", 천식 및 알레르기, 25(2), pp.150~152 (2005), 대한천식알레르기학회