학동전기 소아 알레르기비염의 알레르겐 감작과 대기오염과의 연관성
Relation of allergic rhinitis, allergen sensitization, and air pollutants in preschool children
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Purpose: We aimed to investigate the prevalence and allergen sensitization of allergic rhinitis (AR) in preschool children. We assessed the relationship of AR, allergen sensitization, and air pollutants. Methods: Between 2012 and 2016 in Jincheon, skin prick testing and questionnaire survey were performed on 2,958 children. AR have diagnosed on the basis of current symptoms and sign of AR on the Korean International Study of Asthma and Allergies in Childhood questionnaire and 1 or more proven allergen sensitization. Results: A total of 2,052 children completed survey and skin prick testing, and were included in the analysis. The prevalence of AR symptom within last 12 months and AR were 27.0% and 10.9%, respectively. During study, both prevalences were increased from 20.1% and 8.6%, respectively in 2012 to 29.1% and 12.8%, respectively in 2016. The total inhalant allergen sensitization rate was 32.6%. The most common inhalant allergen was Dermatophagoides farinae (23.1%), followed by Dermatophagoides pteronyssinus (22.5%), tree pollens (5.3%), weed pollens (5.2%), fungi (4.7%), dog hair (4.5%) cat fur (3.6%), grass pollens (1.1%), and cockroach (0.8%). Although there was no difference tree or weed pollen sensitization, pollen seasonal prevalence of current AR symptoms is highest in spring (80%) versus autumn (52.3%). Seasonal PM10 (particulate matter with a median aerodynamic diameter less than or equal to 10 μm in diameter) and SO2 (sulfur dioxide) levels were correlated with the prevalence of seasonal AR symptoms. Pollen seasonal current AR symptoms were significantly related to seasonal pollen sensitization, but not inhalant allergens including dust mites. Conclusion: There was a rapid increasing prevalence of AR in preschool children in the areas of urbanization and industrialization. Pollen seasonal current AR symptoms have a close relationship with PM10 and seasonal pollen sensitization.
Abstract
Purpose: We aimed to investigate the prevalence and allergen sensitization of allergic rhinitis (AR) in preschool children. We assessed the relationship of AR, allergen sensitization, and air pollutants. Methods: Between 2012 and 2016 in Jincheon, skin prick testing and questionnaire survey were performed on 2,958 children. AR have diagnosed on the basis of current symptoms and sign of AR on the Korean International Study of Asthma and Allergies in Childhood questionnaire and 1 or more proven allergen sensitization. Results: A total of 2,052 children completed survey and skin prick testing, and were included in the analysis. The prevalence of AR symptom within last 12 months and AR were 27.0% and 10.9%, respectively. During study, both prevalences were increased from 20.1% and 8.6%, respectively in 2012 to 29.1% and 12.8%, respectively in 2016. The total inhalant allergen sensitization rate was 32.6%. The most common inhalant allergen was Dermatophagoides farinae (23.1%), followed by Dermatophagoides pteronyssinus (22.5%), tree pollens (5.3%), weed pollens (5.2%), fungi (4.7%), dog hair (4.5%) cat fur (3.6%), grass pollens (1.1%), and cockroach (0.8%). Although there was no difference tree or weed pollen sensitization, pollen seasonal prevalence of current AR symptoms is highest in spring (80%) versus autumn (52.3%). Seasonal PM10 (particulate matter with a median aerodynamic diameter less than or equal to 10 μm in diameter) and SO2 (sulfur dioxide) levels were correlated with the prevalence of seasonal AR symptoms. Pollen seasonal current AR symptoms were significantly related to seasonal pollen sensitization, but not inhalant allergens including dust mites. Conclusion: There was a rapid increasing prevalence of AR in preschool children in the areas of urbanization and industrialization. Pollen seasonal current AR symptoms have a close relationship with PM10 and seasonal pollen sensitization.
참고문헌 (26)
- Nimmagadda SR, "Allergy: etiology and epidemiology", Pediatr Rev, 20, pp.111~115 (1999)
- Lee SI, "Prevalences of symptoms of asthma and other allergic diseases in korean children: a nationwide questionnaire survey", J Korean Med Sci, 16, pp.155~164 (2001)[DOI]
- Beasley R, "Prevalence and etiology of asthma", J Allergy Clin Immunol, 105(2 Pt 2), pp.S466~S472 (2000)[DOI]
- 이하백, "New Patterns of Childhood Asthma Pevalence in Six Asian Countries: Comparison of ISAAC Phases I and III", Allergy Asthma & Respiratory Disease, 18(1), pp.70~77 (2008), 대한 소아알레르기 호흡기학회
- [URL]
- 안강모, "2010년 한국 어린이·청소년의 천식, 알레르기 비결막염, 아토피피부염 증상 유병률 조사: 복합표본설계를 이용한 전국 서베이", 대한의사협회지, 54(7), pp.769~778 (2011), 대한의사협회
- 권성은, "광주 지역 소아청소년에서 알레르기비염 유병률과 주요 알레르겐 조사", Allergy Asthma & Respiratory Disease, 3(1), pp.54~61 (2015), 대한 소아알레르기 호흡기학회
- Lim DH, "Epidemiology of allergic rhinitis in Korean children", World Allergy Organ J, 8(Suppl 1), pp.A41~ (2015)[DOI]
- Morgenstern V, "Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children", Am J Respir Crit Care Med, 177, pp.1331~1337 (2008)[DOI]
- 정달영, "Effect of Traffic-Related Air Pollution on Allergic Disease: Results of the Children’s Health and Environmental Research", Allergy, Asthma & Immunology Research, 7(4), pp.359~366 (2015), 대한천식알레르기학회
- Gehring U, "Traffic-related air pollution and the development of asthma and allergies during the first 8 years of life", Am J Respir Crit Care Med, 181, pp.596~603 (2010)[DOI]
- [URL]
- Keil T, "The natural history of allergic rhinitis in childhood", Pediatr Allergy Immunol, 21, pp.962~969 (2010)[DOI]
- Kurukulaaratchy RJ, "The influence of gender and atopy on the natural history of rhinitis in the first 18 years of life", Clin Exp Allergy, 41, pp.851~859 (2011)[DOI]
- Marinho S, "Rhinoconjunctivitis in 5-year-old children: a population-based birth cohort study", Allergy, 62, pp.385~393 (2007)[DOI]
- Mai XM, "Birth anthropometric measures, body mass index and allergic diseases in a birth cohort study (BAMSE)", Arch Dis Child, 92, pp.881~886 (2007)[DOI]
- Tan TN, "Prevalence of asthma and comorbid allergy symptoms in Singaporean preschoolers", Asian Pac J Allergy Immunol, 24, pp.175~182 (2006)
- Wang XS, "The prevalence of asthma and allergies in Singapore; data from two ISAAC surveys seven years apart", Arch Dis Child, 89, pp.423~426 (2004)[DOI]
- [URL]
- Chiu CY, "Sensitization to food and inhalant allergens in relation to atopic diseases in early childhood: a birth cohort study", PLoS One, 9, pp.e102809~ (2014)[DOI]
- Schoos AM, "Disagreement between skin prick test and specific IgE in young children", Allergy, 70, pp.41~48 (2015)[DOI]
- Rhodes HL, "A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status", Am J Respir Crit Care Med, 165, pp.176~180 (2002)[DOI]
- Lee YL, "Climate, traffic-related air pollutants and allergic rhinitis prevalence in middle-school children in Taiwan", Eur Respir J, 21, pp.964~970 (2003)[DOI]
- Kim BK, "Allergies are still on the rise? A 6-year nationwide population-based study in Korea", Allergol Int, 65, pp.186~191 (2016)[DOI]
- 황선혜, "한국 소아의 알레르기비염 역학", Allergy Asthma & Respiratory Disease, 1(4), pp.321~332 (2013), 대한 소아알레르기 호흡기학회
- Hajat S, "Association between air pollution and daily consultations with general practitioners for allergic rhinitis in London, United Kingdom", Am J Epidemiol, 153, pp.704~714 (2001)[DOI]