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Brain-derived neurotrophic factor 와 알쯔하이머병

Brain-derived neurotrophic factor and Alzheimer's disease

김상헌|곽경필|이상희
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2005.12|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제11권 제2호|pp. 121-129

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참고문헌

키워드

BDNFBDNF Neural plasticity Neurogenesis 우울증 항우울제Neural plasticity Neurogenesis Depression Antidepressant
주제분류정신과학

초록

BDNF의 발현이 항우울제의 세포내 신호전달의 목표일 수도 있고, 우울증의 동물 모형에서 BDNF는 항우울제와 같은 효과를 보인다. 게다가 BDNF는 스트레스에 의한 신경세포의 손상을 막고, 해마에서 neurogenesis에도 영향을 준다. 약물치료를 받지 않은 우울증 환자의 혈청 BDNF가 대조군에 비해 감소되어 있고, BDNF가 우울증에서 회복되는 데 중요한 인자일 수도 있다는 임상 연구들이 있다. 이런 연구들은 BDNF가 우울증의 병태생리와 항우울제의 치료적 작용 기전에서 중요한 역할을 하고 있다는 것을 시사하고 있다. 이에 따라 BDNF와 관련된 세포내 신호전달 경로들이 치료적 개입의 새로운 표적이 되고 있다. 그러나 현재까지 우리가 알고 있는 지식은 다양한 신호전달 경로들이 복잡한 상호작용을 통해 정보를 전달하고 진행시켜 반응하도록 하는 복잡한 과정의 일부분에 지나지 않을 수 있다. 이들 복잡한 조절경로들과 이에 관여하는 유전자들을 규명하는 작업은 앞으로 계속적인 과제가 될 것이다.

Abstract

Brain-derived neurotrophic factor (BDNF) is involved in the development, survival, maintenance and plasticity of neurons in the nervous systems. Recent pre-clinical studies suggest that the expression of BDNF is up-regulated by antidepressant treatments and the expression of BDNF might be a downstream target of antidepressant treatments. In addition, BDNF exerts antidepressant activity in animal models of depression. BDNF protects against stress-induced neuronal damage, and it might affect neurogenesis in the hippocampus, which is thought to be involved in the pathogenesis of the depression. In human studies, serum levels of BDNF in drug-naive patients with major depressive disorder are significantly decreased as compared with normal controls, and that BDNF might be a important agent for therapeutic recovery from major depressive disorder. These findings suggest that BDNF plays a critical role in the pathophysiology of depression and in the mechanism of action of antidepressant agents.

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