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알코올가상현실치료：다감각 자극에 대한 알코올 의존 환자의 갈망 및 뇌파 반응

Virtual Reality Alcohol Treatment：Craving and EEG Responding to Multi-Sensory Stimulation in Patient with Alcohol Dependence

이상훈|이영식|오세만|한덕현
대한신경정신의학회 (Korean Neuropsychiatric Association)|2009.07|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제48권 제4호|pp. 255-261

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참고문헌

키워드

가상현실·알코올의존·갈망감·뇌파·전두피질Virtual reality·Alcohol dependence·Craving·EEG·Frontal cortex
주제분류정신과학

초록

본 연구 결과는 알코올 의존 환자의 전두엽은 술마시는 상황에서 정상인에 비해 불안정하게 반응하며, 이것이 술 에 대한 갈망을 증가시키는 것과 관련이 있을 것으로 생각 된다.

Abstract

Objectives In our previous report, alcohol dependent patients (ADP) with virtual reality treatment showed a greater decrease in cravings for alcohol and increase in alpha power of the frontal lobe, compared to ADP who underwent general treatment. For the showing different responsibility on alcohol consumption situation between ADP and healthy comparisons, we compared the change in cravings and alpha waves in frontal lobe during virtual reality treatment for alcohol dependence (VRT). Methods Thirty seven alcohol-dependent male inpatients diagnosed using DSM-IV, and 25 ageand education-matched healthy adult males were recruited. We measured the changes in cravings and Electroencephalogram (EEG) activity between alcoholic patients and healthy control subjects during VRT. Results During the VRT, ADP reported higher craving for alcohol during the high risk situation and lower craving for alcohol during aversive situation, compared to healthy controls. The alpha wave of frontal lobe activity in ADP was decreased while that in healthy subject was increased from relaxation to high risk situation (HRS). In ADP, the changes of EEG (Fp1-A1 (r=-0.48, p=0.04), F7-A1 (r=- 0.49, p=0.03), Fp2-A2 (r=-0.46, p<0.05), and F8-A2 (r=-0.54, p=0.02)) in the frontal lobe were negatively correlated with the change of craving for alcohol. Conclusion The present study demonstrated that the ready availability and the affinity of alcohol cues in ADP appear to be correlated with decreased function of the frontal lobe.

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