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한국인 정신분열병 환자에서 COMT 유전자내의 단일염기 다형성 분석

Analysis of Single Nucleotide Polymorphisms of COMT Gene in Korean Schizophrenics

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주제분류정신과학

초록

Objectives: Catechol-O-methyltransferase (COMT) plays an important role in metabolizing catecholamines,including dopamine. Also, several single-nucleotide polymorphisms (SNPs) of the COMT gene are associated with schizophrenia. Therefore, this study aimed to find the association between COMT gene SNPs and schizophrenia in Koreans. Methods: Participants were 366 schizophrenia patients and 359 normal controls. To identify the SNPs, we performed genetic analyses in 4 SNP regions, via SNP-ITTM assays. We compared allele,genotype, and haplotype frequencies between the two groups. Moreover, we built subgroups,based on onset age, and compared individual allele and genotype frequencies among these subgroups. Results: In female patients, genotype frequencies showed a significant difference in rs2020917among the 4 SNPs (p=0.0224), but haplotype frequencies showed no such difference among the 4 SNPs between patients and controls. We noted a significant difference in rs1544325 allele frequencies according to onset age. Also, in female patients, rs1544325 allele and genotype frequencies varied significantly according to onset age. Conclusion: This study found no genetic association between the COMT gene’ s 4 SNPs and schizophrenia in Koreans. However, our findings suggest genetic components for sex-specificity and onset age in Korean schizophrenics.

Abstract

Objectives: Catechol-O-methyltransferase (COMT) plays an important role in metabolizing catecholamines,including dopamine. Also, several single-nucleotide polymorphisms (SNPs) of the COMT gene are associated with schizophrenia. Therefore, this study aimed to find the association between COMT gene SNPs and schizophrenia in Koreans. Methods: Participants were 366 schizophrenia patients and 359 normal controls. To identify the SNPs, we performed genetic analyses in 4 SNP regions, via SNP-ITTM assays. We compared allele,genotype, and haplotype frequencies between the two groups. Moreover, we built subgroups,based on onset age, and compared individual allele and genotype frequencies among these subgroups. Results: In female patients, genotype frequencies showed a significant difference in rs2020917among the 4 SNPs (p=0.0224), but haplotype frequencies showed no such difference among the 4 SNPs between patients and controls. We noted a significant difference in rs1544325 allele frequencies according to onset age. Also, in female patients, rs1544325 allele and genotype frequencies varied significantly according to onset age. Conclusion: This study found no genetic association between the COMT gene’ s 4 SNPs and schizophrenia in Koreans. However, our findings suggest genetic components for sex-specificity and onset age in Korean schizophrenics.

참고문헌 (38)

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관련 논문AI추천

정신분열병의 인지적 표지자와 Catechol-O-Methyltransferase Val158Met 유전자 다형성의 연합연구김나라, 박동연, 박해정, 이동수, 이유상, 전현옥, 조은영, 홍경수대한신경정신의학회 · 신경정신의학2008 · 제47권 제2호No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population김병권, 김성환, 이경무, 최병무, 홍영습, Ho Jin Kang, Seung-Rak Son한국역학회 · Epidemiology and Health2010 · 제32권 기능성 Catechol-O-Methyltransferase 유전자 다형성과 한국인 정신분열병의 관련성강대희, 김형섭, 박임순, 박태원, 배수영, 윤경식, 최인미, 홍영준대한신경정신의학회 · 신경정신의학2001 · 제40권 제4호한국인 정신분열병 환자의 안구추적운동 이상과 COMT 유전자의 Val108/158Met 다형성의 연합 연구김기훈, 김임렬, 문현일, 박병래, 서한길, 신태민, 신형두, 우성일, 이연정, 이인상, 장호준, 한상우, 한선호대한생물정신의학회 · 생물정신의학2008 · 제15권 제4호Dopamine Beta-Hydroxylase 유전자 내 4개의 단일염기다형성과 한국 정신분열병 환자 간 연관성 연구김종우, 박진경, 반건호, 송지영, 정주호, 조아랑대한생물치료정신의학회 · 생물치료정신의학2007 · 제13권 제1호한국인 조현병 집단에서 에스트로겐 대사(ESR1, COMT) 유전자의 가족연합분석: 예비연구김경원, 문은수, 박제민, 서화규, 이병대, 이수연, 이영민, 정우영, 정희정대한생물치료정신의학회 · 생물치료정신의학2021 · 제27권 제3호

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