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No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population

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초록

OBJECTIVES: Common genetic SNPs in two genes, encoding catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR), which are interconnected with COMT gene regulation, have been reported to contribute to schizophrenia risk. In this study, we evaluated the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk with a case-control study in a Korean population. METHODS: We performed a case-control study by genotyping analysis using 360 cases and 348 controls in Korean subjects to determine the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk. RESULTS: Four functional SNPs in COMT (Val158Met and rs165599) and MTHFR (C677T and A1298C) were genotyped by primer extension assay. None of the genotype distributions for the four SNPs was significantly different between cases and controls. Stratified analysis did not show any significant gender difference for any polymorphism. In addition, we found no evidence of a gene-gene interaction in the analysis of combined genotypes. CONCLUSION: Our results suggest no significant association between the selected functional polymorphisms of COMT or MTHFR in Korean schizophrenia subjects. However, further studies are required to confirm our findings in a larger number of subjects.

Abstract

OBJECTIVES: Common genetic SNPs in two genes, encoding catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR), which are interconnected with COMT gene regulation, have been reported to contribute to schizophrenia risk. In this study, we evaluated the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk with a case-control study in a Korean population. METHODS: We performed a case-control study by genotyping analysis using 360 cases and 348 controls in Korean subjects to determine the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk. RESULTS: Four functional SNPs in COMT (Val158Met and rs165599) and MTHFR (C677T and A1298C) were genotyped by primer extension assay. None of the genotype distributions for the four SNPs was significantly different between cases and controls. Stratified analysis did not show any significant gender difference for any polymorphism. In addition, we found no evidence of a gene-gene interaction in the analysis of combined genotypes. CONCLUSION: Our results suggest no significant association between the selected functional polymorphisms of COMT or MTHFR in Korean schizophrenia subjects. However, further studies are required to confirm our findings in a larger number of subjects.

참고문헌 (37)

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관련 논문AI추천

한국인 정신분열병환자에서 MTHFR 유전자의 단일 염기다형성인 C677T와 A1298C의 연관성 분석강호진, 김병권, 김성환, 김제원, 최병무, 홍영습대한생물치료정신의학회 · 생물치료정신의학2009 · 제15권 제2호한국인 정신분열병 환자에서 COMT 유전자내의 단일염기 다형성 분석강호진, 김성환, 박재홍, 손성락, 이동기, 최병무, 홍영습대한신경정신의학회 · 신경정신의학2010 · 제49권 제2호정신분열병의 인지적 표지자와 Catechol-O-Methyltransferase Val158Met 유전자 다형성의 연합연구김나라, 박동연, 박해정, 이동수, 이유상, 전현옥, 조은영, 홍경수대한신경정신의학회 · 신경정신의학2008 · 제47권 제2호한국인 정신분열병 환자의 안구추적운동 이상과 COMT 유전자의 Val108/158Met 다형성의 연합 연구김기훈, 김임렬, 문현일, 박병래, 서한길, 신태민, 신형두, 우성일, 이연정, 이인상, 장호준, 한상우, 한선호대한생물정신의학회 · 생물정신의학2008 · 제15권 제4호한국인 정신분열병 및 양극성 기분장애와 Catechol-O-Methyltransferase 유전자 다형성 (Valine/Methionine)과의 연합연구김명수, 선석철, 이선우, 이영호, 지익성대한신경정신의학회 · 신경정신의학2001 · 제40권 제3호Serum Homocysteine and Folate Levels in Korean Schizophrenic Patients문석우, Tae Ho Kim대한신경정신의학회 · PSYCHIATRY INVESTIGATION2011 · 제8권 제2호

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