재발성 천명을 나타내는 어린 소아들에서의 혈청 아연치
Serum Zinc Levels in Young Children with Recurrent Wheeze
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Purpose:Zinc is a dietary antioxidant which is crucial for normal development and function of the immune system. Zinc supplementation is reported to reduce respiratory infections and prevent severe pneumonia in children. We examined serum zinc levels in young children who had recurrent wheezing and evaluated the clinical and laboratory findings in relation to serum zinc levels. Methods:Seventy three patients admitted due to lower respiratory infections with wheezing were enrolled. All children had experienced more than 3 episodes of wheezing before admission. Serum zinc levels were measured by using inductively coupled plasma-optical emission spectrometry (ICP-OES), and serum zinc level of ＜64 µg/dL was defined as zinc deficiency. Clinical and laboratory findings were evaluated and compared between the patients with zinc deficiency and those without it. Two age-matched control groups: normal controls (control 1) and patients with acute viral illnesses (control 2) were also studied. Results:Zinc levels were significantly lower in the patient group than in the 2 control groups.(P<0.0001) Zinc deficiency was observed in 49.3% of the patient group, which was significantly higher than in controls.(P<0.0001) Peripheral blood CD4/CD8 was significantly lower in the patients with zinc deficiency than in the subjects with a normal value.(P=0.01) Conclusion:This study showed that the serum zinc level was significantly lower and that zinc deficiency was more frequently observed in the patients with recurrent early wheeze. Zinc deficiency was found to be associated with lower CD4/CD8. Our results suggest that zinc deficiency may be associated with frequent respiratory infections, a likely trigger for recurrent early wheeze.
Abstract
Purpose:Zinc is a dietary antioxidant which is crucial for normal development and function of the immune system. Zinc supplementation is reported to reduce respiratory infections and prevent severe pneumonia in children. We examined serum zinc levels in young children who had recurrent wheezing and evaluated the clinical and laboratory findings in relation to serum zinc levels. Methods:Seventy three patients admitted due to lower respiratory infections with wheezing were enrolled. All children had experienced more than 3 episodes of wheezing before admission. Serum zinc levels were measured by using inductively coupled plasma-optical emission spectrometry (ICP-OES), and serum zinc level of ＜64 µg/dL was defined as zinc deficiency. Clinical and laboratory findings were evaluated and compared between the patients with zinc deficiency and those without it. Two age-matched control groups: normal controls (control 1) and patients with acute viral illnesses (control 2) were also studied. Results:Zinc levels were significantly lower in the patient group than in the 2 control groups.(P<0.0001) Zinc deficiency was observed in 49.3% of the patient group, which was significantly higher than in controls.(P<0.0001) Peripheral blood CD4/CD8 was significantly lower in the patients with zinc deficiency than in the subjects with a normal value.(P=0.01) Conclusion:This study showed that the serum zinc level was significantly lower and that zinc deficiency was more frequently observed in the patients with recurrent early wheeze. Zinc deficiency was found to be associated with lower CD4/CD8. Our results suggest that zinc deficiency may be associated with frequent respiratory infections, a likely trigger for recurrent early wheeze.
참고문헌 (28)
- Dreosti IE, "Recommended dietary intakes of iron, zinc, and other inorganic nutrients and their chemical form and bioavailability", Nutrition, 9, pp.542~545 (1993)
- Hambidge M, "Inter-relationships of key variables of human zinc homeostasis: relevance to dietary zinc requirements", Ann Rev Nutr, 21, pp.429~452 (2001)
- Vallee BL, "The biochemical basis of zinc physiology", Physiol Rev, 73, pp.79~118 (1993)
- Shankar AH, "Zinc and immune function: the biological basis of altered resistance to infection", Am J Clin Nutr, 68(2), pp.447~463 (1998)
- Prasad AS, "Zinc and immunity", Mol Cell Biochem, 188, pp.63~69 (1998)
- Powell SR, "The antioxidant properties of zinc", J Nutr, 130, pp.1447~1454 (2000)
- Carter JE, "Involvement of redox events in caspase activation in Zn-depleted airway epithelial cells", Biochem Biophys Res Commum, 297, pp.1062~1070 (2002)
- Fernandes G, "Impairment of cell mediated immune functions by dietary Zn deficiency in mice", Proc Natl Acad Sci USA, 통권 : 76, pp.457~461 (1979)
- Allen JI, "Alterations in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency", J Lab Clin Med, 102, pp.577~589 (1983)
- Chandra RK, "Single nutrient deficiency and cell-mediated immune responses. I. Zinc", Am J Clin Nutr, 33, pp.736~738 (1980)
- Black RE, "Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries", Am J Clin Nutr, 68, pp.476~479 (1998)
- Keen CL, "Zinc deficiency and immune function", Annu Rev Nutr, 10, pp.415~431 (1990)
- Feiler LS, "Herpetic keratitis in Zinc deficient rabbits", Invest Ophthalmol Vis Sci, 22, pp.788~795 (1982)
- Singh KP, "Effect of zinc on immune functions and host resistance against infection and tumor challenge", Immunopharmacol Immunotoxicol, 14, pp.813~840 (1992)
- Cuevas LE, "Zinc and infection: a review", Ann Trop Paediatr, 25, pp.149~160 (2005)
- Shenkin A, "Trace elements and inflammatory response: implications for nutritional support", Nutrition, 11, pp.100~105 (1995)
- Sazawal S, "Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children : a double-blind, controlled trial", Pediatrics, 102, pp.1~5 (1998)
- Baqui AH, "Simultaneous weekly supplementation of iron and zinc is associated with lower morbidity due to diarrhea and acute lower respiratory infection in Bangladeshi infants", J Nutr, 133, pp.4150~4157 (2003)
- Brooks WA, "Effect of weekly zinc supplements on incidence of pneumonia and diarrhea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial", Lancet, 366, pp.999~1004 (2005)
- Truong-Tran AQ, "New insights into the role of zinc in the respiratory epithelium", Immunol Cell Biol, 79, pp.170~177 (2001)
- Zalewski PD, "Zinc metabolism in airway epithelium and airway inflammation : basic mechanisms and clinical targets. A review", Pharmaco Ther, 105, pp.127~149 (2005)
- Truong-Tran AQ, "Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation", Am J Respir cell Mol Biol, 27, pp.286~296 (2002)
- Behrman RE, "Nelson textbook of Pediatrics", pp.2414~ (2004), Saunders: International Edition
- Prasad AS, "Effects of zinc deficiency on Th1 and Th2 cytokine shifts", J Infect Dis, 182, pp.62~68 (2000)
- Beck FW, "Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans", Am J Physiol, 272, pp.E1002~E1007 (1997)
- Di Toro R, "Zinc and copper status of allergic children", Acta Paediatr Scand, 76, pp.612~617 (1987)
- Aggarwal BB, "Nuclear transcription factor NF kappa B : role in biology and medicine", Indian J Exp Biol, 42, pp.341~353 (2004)
- Ho LH, "Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-κB translocatoin", J immunol, 172, pp.7750~7760 (2004)