반복되는 천명을 주소로 내원한 3세 미만의 환아에서 25-hydroxyvitamin D의 혈청 내 농도와 관련된 인자
Factors associated with serum vitamin D levels in children with recurrent wheezing less than 3 years old
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Purpose: We evaluated the relationship between laboratory/clinical factors and vitamin D levels in recurrent wheezers less than 3 years old. Methods: We retrospectively analyzed clinical data and laboratory factors (25-hydroxyvitamin D, complete blood count, C-reactive protein, glutamic oxaloacetic transaminase, glutamyl purovic transaminase, alkaline phosphatase [ALP], eosinophil counts, and serum IgE IgG, IgA, IgM) of 84 children less than 3 years who had experienced wheezing episodes at least 3 times. Results: Children in the normal group (1.4±0.9 years) were younger than those in the deficient (2.2±1.2 years) and insuffient (2.31.0 years) groups (P=0.010). Glutamyl purovic transaminase were higher in the normal group (24.5±19.4 IU/L) than in the deficient (16.0±4.7 IU/L) and insufficient (15.3±4.5 IU/L) groups (P=0.009). ALP were higher in the deficient (791.4±180.8 IU/L) and insufficient (770.4±251.2 IU/L) groups than in the normal group (631.9±127.0 IU/L, P=0.034). Total IgE levels were higher in the deficient group (171.9±212.1 kU/L) than in the normal group (43.7±58.3 kU/L, P<0.05), and the rate of sensitization to aeroallergens was higher in the insufficient group (36.1%) than in the normal group (10%, P<0.05). Conclusion: Among children with recurrent wheezing less than 3 years old, low vitamin D levels may be associated with older age, total IgE, ALP level, glutamic pyruvate transaminase level, and rate of sensitization to aeroallergens.
Abstract
Purpose: We evaluated the relationship between laboratory/clinical factors and vitamin D levels in recurrent wheezers less than 3 years old. Methods: We retrospectively analyzed clinical data and laboratory factors (25-hydroxyvitamin D, complete blood count, C-reactive protein, glutamic oxaloacetic transaminase, glutamyl purovic transaminase, alkaline phosphatase [ALP], eosinophil counts, and serum IgE IgG, IgA, IgM) of 84 children less than 3 years who had experienced wheezing episodes at least 3 times. Results: Children in the normal group (1.4±0.9 years) were younger than those in the deficient (2.2±1.2 years) and insuffient (2.31.0 years) groups (P=0.010). Glutamyl purovic transaminase were higher in the normal group (24.5±19.4 IU/L) than in the deficient (16.0±4.7 IU/L) and insufficient (15.3±4.5 IU/L) groups (P=0.009). ALP were higher in the deficient (791.4±180.8 IU/L) and insufficient (770.4±251.2 IU/L) groups than in the normal group (631.9±127.0 IU/L, P=0.034). Total IgE levels were higher in the deficient group (171.9±212.1 kU/L) than in the normal group (43.7±58.3 kU/L, P<0.05), and the rate of sensitization to aeroallergens was higher in the insufficient group (36.1%) than in the normal group (10%, P<0.05). Conclusion: Among children with recurrent wheezing less than 3 years old, low vitamin D levels may be associated with older age, total IgE, ALP level, glutamic pyruvate transaminase level, and rate of sensitization to aeroallergens.
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