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Neuroprotective Effect of Yukmijihwang-tang(Liuweidihuangtang) Gamibang on the Deficits of Learning and Memory in Trimethyltin-Intoxicated Rats

김근우|구병수|정희상
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2009.03|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제20권 제1호|pp. 75-88

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참고문헌

키워드

트리메틸틴육미지황가미방학습과 기억신경퇴행콜린 아세틸전환효소
주제분류한의학

초록

목적 : 이 연구는 알쯔하이머 병에 대한 육미지황가미방의 효과를 조사하였다. 육미지황가미방은 산약, 산수유, 복령, 목단피, 구기자, 택사, 숙지황을 포함한 여러 가지 한약재의 전탕액으로 치매의 한약 치료제로 널리 사용되어 왔다. 방법 : 이 약물의 신경보호 작용을 조사하기 위해, 수중미로를 사용하여 학습과 기억에 대한 육미지황가미방의 효과를 평가했고, 트리메틸틴으로 신경과 인지 장애를 유발시킨 쥐의 해마의 중추성 콜린계에서의 작용을 연구했다. 트리메틸틴은 강력한 유독물질로 선택적으로 중추신경계와 면역계의 세포를 파괴시킨다. 트리메틸틴(6.0 mg/kg, i.p.) 주입 후, 쥐에게 육미지황가미방(400 mg/kg, p.o.)를 2주 동안 날마다 복용시켰으며, 수중미로를 수행시켰다. 결과 : 육미지황가미방을 트리메틸틴에 노출시킨 쥐에 투약했으며, 그들은 수중미로에서 학습과 기억의 향상을 보였고, 이는 육미지황가미방이 어떠한 환경에서는 트리메틸틴으로 유발된 신경퇴화 후 중추신경계의 결손을 감소시킬 수 있음을 보여준다. 결론 : 이러한 결론은 육미지황가미방이 인지능력을 증가시키고, 트리메틸틴으로 유발된 신경퇴화에서 콜린 아세틸전환효소의 정도를 변화시킬 수 있음을 보여준다.

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