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장뇌삼 잎 추출물의 분획물이 Scopolamine으로 유도된 Mouse의 기억력 개선에 미치는 영향

Effects of Korean Mountain Ginseng Leaves and Its Active Constituents on Scopolamine-induced Amnesia in Mouse

김수현|박선영|정대규|김주봉
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2010.03|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제21권 제1호|pp. 125-144

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참고문헌

키워드

MemoryScopolamineExtracellular signal-regulated kinaseKorean Mountain GinsengAcetylcholine esterase activityImmunihistochemistry
주제분류한의학

초록

Objectives : The purpose of this study was to characterize the effect of the fraction of Korean mountain ginseng folium (FKG) on the learning and memory impairments induced by scopolamine. Methods : The memory ameliorating effect of FKG was investigated using a passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : FKG (2 or 4 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance test and the Y-maze test (P<0.05), and also improved escape latency in the Morris water maze test at 2 or 4 mg/kg (P<0.05). Although FKG has little inhibitory activity for AChE (IC50 value; 1847 μg/ml) in an invitro study, phosphorylated extracellular signal-regulated kinase (pERK) was increased by the administration of FKG in hippocampus on immunohistochemistry. Conclusions : These results suggest that FKG may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via activation of ERK pathway.

Abstract

Objectives : The purpose of this study was to characterize the effect of the fraction of Korean mountain ginseng folium (FKG) on the learning and memory impairments induced by scopolamine. Methods : The memory ameliorating effect of FKG was investigated using a passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : FKG (2 or 4 mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance test and the Y-maze test (P<0.05), and also improved escape latency in the Morris water maze test at 2 or 4 mg/kg (P<0.05). Although FKG has little inhibitory activity for AChE (IC50 value; 1847 μg/ml) in an invitro study, phosphorylated extracellular signal-regulated kinase (pERK) was increased by the administration of FKG in hippocampus on immunohistochemistry. Conclusions : These results suggest that FKG may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via activation of ERK pathway.

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