ACM의 Sprague-Dawley Rat 경구 단회 투여 독성시험
Single Oral Dose Toxicity Test of ACM(Added Chongmyung-tang) in Sprague-Dawley Rat
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초록
Objectives :This research investigates the single oral dose toxicity of ACM in SD rats. Methods :ACMs were administered to female and male SD rats, as an oral dose of 5000 ㎎/㎏. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing,upon necropsy. Results :We could not find any mortality. Compared with the control group, significant weight change was not observed in the experimental group. First day after administration, compound-colored stool was observed in all rats. After the second day of administration, the more common symptoms were not observed. There were no gross abnormalities in all cases. [ED NOTE: highlight: given the context, this is very vague]Conclusions :The results obtained in this study suggest that the approximate lethal dose of ACM in both female and male rats were considered as over 5000 ㎎/㎏.
Abstract
Objectives :This research investigates the single oral dose toxicity of ACM in SD rats. Methods :ACMs were administered to female and male SD rats, as an oral dose of 5000 ㎎/㎏. Animals were monitored for the mortality and changes in the body weight, clinical signs and gross observation during the 14 days after dosing,upon necropsy. Results :We could not find any mortality. Compared with the control group, significant weight change was not observed in the experimental group. First day after administration, compound-colored stool was observed in all rats. After the second day of administration, the more common symptoms were not observed. There were no gross abnormalities in all cases. [ED NOTE: highlight: given the context, this is very vague]Conclusions :The results obtained in this study suggest that the approximate lethal dose of ACM in both female and male rats were considered as over 5000 ㎎/㎏.
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