제2형 당뇨병 환자에서 Vitamin D와 HbA1c 및 Fructosamine과의 관련성
Relationship of Vitamin D Levels with HbA1c and Fructosamine in Korean Type 2 Diabetic Patients
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: Although previous studies reported an association of serum vitamin D with glycated hemoglobin (HbA1c) and fructosamine, the relationships remain unclear. Therefore, this study aims to identify the relationships of serum vitamin D with HbA1c and fructosamine independent of parathyroid hormone (PTH) in Korean type 2 diabetic patients. Methods: Total 227 adults (male 112 and female 115) who treated for type 2 diabetes in a general hospital participated in this study. The serum vitamin D, HbA1c, fructosamine and fasting blood glucose (FBG) were measured in participants who met the detailed inclusion criteria. The level of serum vitamin D was defined as follows; deficient: <10.0 ng/mL, insufficient: 10.0-19.9 ng/mL, optimal: ≥20.0 ng/m. Results: In the analysis of covariance, after adjusted for other covariates including PTH, the means (standard error, SE) values of HbA1c became lower with higher serum vitamin D level (deficiency: 7.8 [0.2]%, insufficient: 7.5 [0.1]%, optimal: 7.2 [0.1]%, p=0.015). Also, after adjusted for other covariates including PTH, the mean (SE) values of fructosamine became lower with higher serum vitamin D level (deficiency: 357.1 [13.1] µmol/L, insufficient: 344.5 [4.9] µmol/L, optimal: 313.3 [6.4] µmol/L, p=0.001). However, the mean values of FBG were not significantly associated with the serum vitamin D level. Conclusions: There were significant associations of vitamin D with HbA1c and fructosamine independent of PTH, but there was no association of vitamin D with FBG in Korean type 2 diabetic patients.
Abstract
Objectives: Although previous studies reported an association of serum vitamin D with glycated hemoglobin (HbA1c) and fructosamine, the relationships remain unclear. Therefore, this study aims to identify the relationships of serum vitamin D with HbA1c and fructosamine independent of parathyroid hormone (PTH) in Korean type 2 diabetic patients. Methods: Total 227 adults (male 112 and female 115) who treated for type 2 diabetes in a general hospital participated in this study. The serum vitamin D, HbA1c, fructosamine and fasting blood glucose (FBG) were measured in participants who met the detailed inclusion criteria. The level of serum vitamin D was defined as follows; deficient: <10.0 ng/mL, insufficient: 10.0-19.9 ng/mL, optimal: ≥20.0 ng/m. Results: In the analysis of covariance, after adjusted for other covariates including PTH, the means (standard error, SE) values of HbA1c became lower with higher serum vitamin D level (deficiency: 7.8 [0.2]%, insufficient: 7.5 [0.1]%, optimal: 7.2 [0.1]%, p=0.015). Also, after adjusted for other covariates including PTH, the mean (SE) values of fructosamine became lower with higher serum vitamin D level (deficiency: 357.1 [13.1] µmol/L, insufficient: 344.5 [4.9] µmol/L, optimal: 313.3 [6.4] µmol/L, p=0.001). However, the mean values of FBG were not significantly associated with the serum vitamin D level. Conclusions: There were significant associations of vitamin D with HbA1c and fructosamine independent of PTH, but there was no association of vitamin D with FBG in Korean type 2 diabetic patients.
참고문헌 (32)
- "Standards of medical care in diabetes-2010", Diabetes Care, 33(Suppl 1), pp.S11~S61 (2010)
- American Diabetes Association, "Diagnosis and classification of diabetes mellitus", Diabetes Care, 37(Supplement 1), pp.S81~S90 (2014)
- Krishnamurti U, "Glycohemoglobin : a primary predictor of the development or reversal of complications of diabetes mellitus", Clin Chem, 47(7), pp.1157~1165 (2001)
- Johnson RN, "Fructosamine: a new approach to the estimation of serum glycosylprotein. An index of diabetic control", Clin Chim Acta, 127(1), pp.87~95 (1983)
- Barr RG, "Tests of glycemia for the diagnosis of type 2 diabetes mellitus", Ann Intern Med, 137(4), pp.263~272 (2002)
- Holick MF, "Vitamin D : a millenium perspective", J Cell Biochem, 88(2), pp.296~307 (2003)
- Inouye K, "Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase(CYP27B1)and 24-hydroxylase(CYP24)", Biotechnol Annu Rev, 7, pp.179~194 (2001)
- Christodoulou S, "Vitamin D and bone disease", Biomed Res Int, 2013, pp.396541~ (2013)
- Pludowski P, "Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence", Autoimmun Rev, 12(10), pp.976~989 (2013)
- Holick MF, "High prevalence of vitamin D inadequacy and implications for health", Mayo Clin Proc, 81(3), pp.353~373 (2006)
- Kositsawat J, "Association of A1C levels with vitamin D status in U.S. adults: data from the National Health and Nutrition Examination Survey", Diabetes Care, 33(6), pp.1236~1238 (2010)
- Choi SW, "25-hydroxyvitamin D and parathyroid hormone levels are independently associated with the hemoglobin A1c level of Korean type 2 diabetic patients : the Dong-Gu study", PLoS One, 11(6), pp.e0158764~ (2016)
- Joergensen C, "Vitamin D levels and mortality in type 2 diabetes", Diabetes Care, 33(10), pp.2238~2243 (2010)
- Thacher TD, "Vitamin D insufficiency", Mayo Clin Proc, 86(1), pp.50~60 (2011)
- Lim S, "Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects", Am J Clin Nutr, 97(3), pp.524~530 (2013)
- Pittas AG, "Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women", Diabetes Care, 33(9), pp.2021~2023 (2010)
- Song Y, "Blood 25-hydroxy vitamin D levels and incident type 2 diabetes : a meta-analysis of prospective studies", Diabetes Care, 36(5), pp.1422~1428 (2013)
- Miñambres I, "Hypovitaminosis D in type 2 diabetes : relation with features of the metabolic syndrome and glycemic control", Endocr Res, 40(3), pp.160~165 (2015)
- Takiishi T, "Vitamin D and diabetes", Endocrinol Metab Clin North Am, 39(2), pp.419~446 (2010)
- Holick MF, "McCollum Award Lecture, 1994 : vitamin D―new horizons for the 21st century", Am J Clin Nutr, 60(4), pp.619~630 (1994)
- Boland ARD, "Influx of extracellular calcium mediates 1, 25-dihydroxyvitamin D3-dependent transcaltachia(the rapid stimulation of duodenal Ca2+ transport)", Endocrinology, 127(5), pp.2475~2480 (1990)
- d’Emden MC, "The in vitro effect of 1 alpha, 25-dihydroxyvitamin D3 on insulin production by neonatal rat islets", Biochem Biophys Res Commun, 164(1), pp.413~418 (1989)
- Kolb H, "An immune origin of type 2 diabetes?", Diabetologia, 48(6), pp.1038~1050 (2005)
- Lemire JM, "Immunomodulatory actions of 1, 25-Dihydroxyvitamin D3", J Steroid Biochem Mol Biol, 53(1), pp.599~602 (1995)
- Dalgard C, "Vitamin D status in relation to glucose metabolism and type 2 diabetes in Septuagenarians", Diabetes Care, 34(6), pp.1284~1288 (2011)
- Madar AA, "Effect of vitamin D3 supplementation on glycated hemoglobin(HbA1c), fructosamine, serum lipids, and body mass index : a randomized, double-blinded, placebo-controlled trial among healthy immigrants living in Norway", BMJ Open Diabetes Res Care, 2(1), pp.e000026~ (2014)
- Rahman NMA, "Study the effect of Zinc", or Vit.D3 on percentage of healing of diabetic foot ulcer in Iraqi patients, 2013, pp.2, 600~604
- Maestro B, "Stimulation by 1, 25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells", Endocr J, 47(4), pp.383~391 (2000)
- Slominski AT, "In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1", FASEB J, 26(9), pp.3901~3915 (2012)
- Slominski AT, "Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland", Sci Rep, 5, pp.14875~ (2015)
- Zbytek B, "20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation", J Invest Dermatol, 128(9), pp.2271~2280 (2008)