광주 소재 한 종합병원을 방문한 성인에서 혈중 Osteocalcin과 HbA1c의 상관관계
Correlation between Serum Osteocalcin and Hemoglobin A1c in Gwangju General Hospital Patients
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초록
최근 골대사와 당뇨병 발생 기전의 관계에 대해 많은 연구가 진행되고 있으며, osteocalcin이 제 2형 당뇨병을 위한 치료법에 관련될 수 있다는 것이 밝혀지고 있다. 따라서 본 연구는 osteocalcin과 HbA1c의 상관관계를 알아보고자 한다. 2015년 1월 1일부터 2016년 12월 31일까지 광주 소재 한 종합병원 수진자 중 osteocalcin과 HbA1c를 비롯하여 칼슘, 카르복시말단펩티드, 총 콜레스테롤, 중성지방, 고밀도 지질단백 콜레스테롤, 저밀도 지질단백 콜레스테롤, 25-수산화비타민D, 키, 몸무게를 측정한 40세 이상의 성인 총 714명(70.8±10.4세)을 연구대상자로 최종 선정하였다. 성별은 남자(452명, 63.3%)가 여자(262명, 36.7%)보다 많았다. 당뇨환자군에서 osteocalcin과 HbA1c는 약한 음의 상관관계(r=−0.183, P＜0.001)가 있었고, 다른 요인들을 모두 보정했을 때에도 여전히 음의 상관관계(r=−0.251, P＜0.001)가 있었다. 본 연구는 당뇨환자에서의 osteocalcin과 HbA1c가 음의 상관관계가 있음을 보여주었다. 골대사와 당대사의 생물학적 기전 및 관련요인들이 미치는 영향을 바탕으로 골대사와 당뇨병 발생의 상호관계에 대한 연구가 지속되어야 한다.
Abstract
Recently, there have been many studies on the relationship between the bone metabolism and the mechanism of diabetes. In those studies, it was shown that osteocalcin can be involved in the treatment of type 2 diabetes. Therefore, this study examined the correlation between osteocalcin and HbA1c. From January 1, 2015 to December 31, 2016, a total of 714 adults aged 40 years or older (70.8±10.4 years, 452 males), in whom both osteocalcin and HbA1c checked in a general hospital in Gwangju, were enrolled in the study. The serum calcium, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, and 25-(OH) vitamin D were measured and basic information, such as the height and weight, were recorded. There was a weak negative correlation (r=−0.183, P＜0.001) between the osteocalcin and HbA1c levels in diabetic patients but a negative correlation (r=−0.251, P＜0.001) when adjusted by all other study variables. The present study showed that there was a negative correlation between the osteocalcin and HbA1c levels in diabetic patients. The relationship between the bone metabolism and the incidence of diabetes mellitus should be studied based on the influence of biological mechanisms and associated factors of bone and glucose metabolism.
참고문헌 (29)
- 오기원, "당뇨병과 골다공증", Diabetes and Metabolism Journal, 33(3), pp.169~177 (2009), 대한당뇨병학회
- 한아름, "당뇨병이 없는 농촌지역의 건강한 성인 남녀에서 당화혈색소와 내장지방과의 관계", 농촌의학.지역보건, 37(4), pp.215~222 (2012), 한국농촌의학.지역보건학회
- 이영실, "한국인 당뇨병의 진단을 위한 당화혈색소 측정의 유용성", 대한내과학회지, 80(3), pp.291~297 (2011), 대한내과학회
- Ferron M, "Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism", Cell, 142, pp.296~308 (2010)[DOI]
- Wang Q, "The relationship between serum osteocalcin concentration and glucose metabolism in patients with Type 2 diabetes mellitus", Int J Endocrinol, 7 (2013)
- 김기준, "국내 건강검진센터를 방문한 당뇨가 없는 건강한 여성에서 혈중 오스테오칼신과 체질량지수와의 상관관계", Journal of Obesity & Metabolic Syndrome, 20(2), pp.51~58 (2011), 대한비만학회
- Chen Y, "Association between serum osteocalcin and glucose", lipid metabolism in Chinese Han and Uygur populations with Type 2 diabetes mellitus in Xinjiang: two cross-sectional studies, 2017, pp.16, 139~
- [URL]
- Bao YQ, "Relationship between serum osteocalcin and glycaemic variability in Type 2 diabetes", Clin Exp Pharmacol Physiol, 38, pp.50~54 (2011)[DOI]
- Lipscombe LL, "The risk of hip fractures in older individuals with diabetes: a population-based study", Diabetes Care, 30, pp.835~841 (2007)[DOI]
- Zhou M, "Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals", Eur J Endocrinol, 161, pp.723~729 (2009)[DOI]
- Xuan Y, "Positive association between serum levels of bone resorption marker CTX and HbA1c in women with normal glucose tolerance", J Clin Endocrinol Metab, 100, pp.274~281 (2015)[DOI]
- Urano T, "Low serum osteocalcin concentration is associated with incident type 2 diabetes mellitus in Japanese women", J Bone Miner Metab, 36, pp.470~477 (2017)
- Parfitt AM, "Vitamin D and bone health in the elderly", Am J Clin Nutr, 36, pp.1014~1031 (1982)[DOI]
- Auwerx J, "Relation between 25-hydroxyvitamin D3, apolipoprotein A-1 and high density lipoprotein cholesterol", Arterioscler Thromb, 12, pp.671~674 (1992)[DOI]
- Chiu KC, "Hypovitaminosis D is associated with insulin resistance and beta cell dysfuntion", Am J Clin Nutr, 79, pp.820~825 (2004)[DOI]
- 김미연, "한국 성인의 비타민D 섭취량과 혈중 25OHD 농도 및 골밀도와의 관련성 : 2011 국민건강영양조사 결과 재분석", Journal of Nutrition and Health, 49(6), pp.437~446 (2016), 한국영양학회
- Starup-Linde J, "Diabetes, biochemical markers of bone turnover, diabetes control, and bone", Front Endocrinol (Lausanne), 4, pp.21~ (2013)
- [URL]
- Tentolouris N, "Type 2 diabetes mellitus is associated with obesity, smoking and low socioeconomic status in large and representative samples of rural, urban, and suburban adult Greek populations", Hormones (Athens), 11, pp.458~467 (2012)[DOI]
- 권세영, "당뇨병 및 공복혈당장애 예측을 위한 당화혈색소 값", 대한임상검사과학회지, 49(2), pp.114~120 (2017), 대한임상검사과학회[DOI]
- Chubb SA, "Measurement of C-terminal telopeptide of type I collagen (CTX) in serum", Clin Biochem, 45, pp.928~935 (2012)[DOI]
- Chung YS, "The relationship between vitamin D levels and chronic diseases", Korean J Clin Geriatr, 11, pp.154~169 (2010)
- Holick MF, "Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis", Am J Clin Nutr, 79, pp.362~371 (2004)[DOI]
- Ducy P, "The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism", Diabetologia, 54, pp.1291~1297 (2011)[DOI]
- Ferron M, "Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice", Bone, 50, pp.568~575 (2012)[DOI]
- Kim DW, "Hemoglobin Alc levels according to duration and complications of diabetes mellitus", The DongGuk Journal of Medicine, 6, pp.424~435 (1999)
- Qvist P, "Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting", Bone, 31, pp.57~61 (2002)[DOI]
- Maddaloni E, "Osteocalcin levels are inversely associated with Hba1c and BMI in adult subjects with long-standing type 1 diabetes", J Endocrinol Invest, 37, pp.661~666 (2014)[DOI]