폐경기 여성에서의 골밀도에 따른 혈청 호모시스테인 농도
Homocysteine Levels and the BMD in Postmenopausal Women
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적: 현재 homocysteinuria가 있는 환자들에게서 골다공증의 유병률이 높다는 사실에 착안하여 혈청 호모시스테인 농도와 골절, 골밀도의 상관관계를 밝히기 위해 외국에서 여러 연구들이 진행되고 있으나 그 연관성은 아직 정립된 이론이 없다. 본 연구는 우리나라의 연구 결과가 미비한 점을 감안하여 골다공증에 취약한 폐경기 여성에서 혈청 호모시스테인 농도에 따른 골밀도의 차이에 대해 알아보고자 하였다. 방법: 2004년 2월부터 2005년 2월까지 서울 소재 일개 대학병원 건강검진센터를 방문한 폐경기 여성 200명을 대상으로 폐경기 여성을 요추 및 대퇴골 골밀도에 따라 정상군, 골감소증군, 골다공증군으로 분류하여 각각의 혈청 호모시스테인 수치를 검정하였다(by ANOVA and post hoc). 결과: 정상군, 골감소증군, 골다공증의 호모시스테인 수치는 각각 7.01±1.73mg/dL, 7.26±1.08mg/dL, 6.62±1.51mg/dL로 나타났으며 각 군 간의 호모시스테인 수치는 유의한 차이를 보이지 않았다. 결론: 폐경기 여성에서 혈청 호모시스테인 농도에 따른 골밀도의 차이는 통계적으로 유의한 차이를 나타내지 못하였다. 호모시스테인이 단백질의 cross linking을 방해하여 뼈의 질을 낮추기는 하나 뼈의 양에는 큰 영향을 미치는 않는 것으로 생각되며 이를 입증하기 위해서는 향후 대규모의 연구가 진행되어야 할 것이다.
Abstract
Objectives: The presence of homocysteine is associated with the early onset of generalized osteoporosis. It has been hypothesized that the homocysteine is involved in osteoporosis. A foreign study suggested the possible involvement of increased plasma homocysteine levels in BMD is unknown. In this study, to examine the influence of homocysteine on osteoporosis, we studied the relationship between homocysteine levels and the BMD in korean postmenopausal women. Methods: The subjects were 200 postmenopausal women who visited a health promotion center of a university hospital in seoul from February 2004 to February 2005. We assigned the women to 3 group by lumbar 2-4 BMD and Femur neck BMD and checked the serum homocysteine levels and then analyzed by ANOVA. Results: In the normal BMD group, the homocysteine levels was 7.01±1.73mg/dL, in the osteopenic group, 7.26±1.08mg/dL, in the osteoporotic group, 6.62±1.51mg/dL, respectively. Thus it was non-significant. Conclusion: In the postmenopausal women serum homocysteine levels according to BMD is not significant in analysis.
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