한국 성인여성에서 골대사 지표(Osteocalcin, Bone Specific Alkaline Phosphatase and Cross-linked C Telopeptides of Type I Collagen)와 골밀도의 연령별 변화 및 상관성
Age-related Changes of Serum Bone Turnover Marker(Osteocalcin, Bone Specific Alkaline Phosphatase and Cross-linked C Telopeptides of Type I Collagen) and the Relationship with Bone Mineral Density in Korean Women
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목적: 한국 여성을 대상으로 골대사지표들(OC, BSAP, sCTX)의 연령에 따른 변화와 골밀도와의 상관성을 알아보고자 한다. 방법: 2002년 2월부터 2005년 1월까지 서울소재 일개 대학병원 건강검진센터를 내원한 30대에서 60대의 905명의 여성을 대상으로 요추(L2-4)와 대퇴골경부에서 골밀도를 측정하였으며, 골대사지표 중 OC, BSAP, sCTX 등을 포함한 혈액검사를 시행하였다. 결과: 연령이 증가하면서 대퇴골경부와 요추의 골밀도 모두 통계학적으로 유의한 음의 상관관계를 가지고 있었다(P<0.001). 모든 골지표대사(OC, BSAP, CTX)는 연령이 증가하면서 증가소견을 보였으며, 특히 폐경주변기(40대와 50대 사이)에서 모두 통계학적으로 유의하게 증가소견을 보였다(P<0.001). 골밀도에 따라 정상, 골감소증과 골다공증 3군으로 나누었을 때 BSAP와 CTX 소견이 각각의 군에서 유의하게 증가하는 소견을 보였다(P<0.001). 결론: 한국여성에서의 골밀도는 폐경기 주변기인 40-50대에서 골밀도가 큰 폭으로 감소하며, 골대사 지표인 OC, BAP와 CTX 모두는 연령이 증가함에 따라 유의하게 증가 소견을 보였으며, BSAP와 CTX는 골다공증 군에서 유의하게 증가되어 있었다.
Abstract
Objectives: This study investigated age-related changes of serum bone turnover marker(osteocalcin(OC), bone specific alkaline phosphatase(BSAP) and cross-linked C telopeptides of type I collagen(CTX)) and the relationship with bone mineral density(BMD) in Korean women Methods: From February 2002 to January 2005 we retrospectively reviewed 905 women aged 30～69 years who had no known diseases and did not take any drugs and operations affecting bone metabolism. OC, serum BSAP and serum CTX(sCTX) were measured to evaluate the state of bone formation and resorption, respectively. BMD was measured in the lumbar spine and femur neck using a dual-energy X-ray absorptiometry(DEXA). Results: The prevalence of osteoporosis increasing decades(4 groups: thirties, forties, fifties, sixties) were 4.5%, 13.6%, 55.3%, 62.0% and there were significantly negative correlation between age and BMD(L-spine and femur neck all)(P<0.001). There were significantly positive correlation between age and all bone turnover markers (OC, BSAP, CTX) specially during perimenopause phase(forties, fifties decades)(p<0.001) There were significantly negative correlation between all bone turnover markers and BMD(L-spine and femur neck all)(P<0.001). Conclusion: In Korea women, BMD showed a large decline in perimenopausal age(forties and fifties) and all bone turnover markers(OC, BSAP, CTX) were significantly increased according to age increasing and BSAP and CTX were significantly increased in osteoporosis group.
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