중년 여성에서 혈청 호모시스테인 농도와 골밀도와의 연관성
Association between Serum Homocysteine Concentrations and Bone Mineral Density in Middle Aged Women
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초록
연구목적: 고호모시스테인혈증이 이른 골다공증과 연관되어 있다는 것은 잘 알려져 있다. 본 연구에서는 중년 여성에서 혈청 호모시스테인 농도가 골밀도와 연관이 있는지 알아보고자 하였다. 연구재료 및 방법: 이 연구는 2009년 1월부터 2010년 10월까지 대학병원의 건강검진센터에 내원하고 골밀도 검사를 시행받은 여성 중 409명을 대상으로 하였다. 모두 골밀도 외에 혈청 호모시스테인 농도를 측정하였다. 결과: 폐경 군 (n = 109)이 폐경 전 군 (n = 300)에 비해 유의하게 높은 혈청 호모시스테인 농도와 유의하게 낮은 요추 및 대퇴목의 골밀도 수치를 보였다. 그러나 나이와 체질량지수 및 폐경 여부를 보정한 분석에서는 혈청 호모시스테인 농도와 골밀도간의 유의성은 보이지 않았다. 결론: 중년 여성에서 혈청 호모시스테인의 측정은 골다공증의 지표로 유용하지 못하나, 보조적으로 사용할 수 있다.
Abstract
Objectives: Hyperhomocysteinemia is known to be related with the early onset of osteoporosis. This study was to examine the association between serem homocysteine levels and bone mineral density (BMD) in middle aged women. Methods: The study included 409 women who underwent bone density tests in the health screening centers from January 2009 to october 2010. Serum homocysteine levels and BMD were measured. Results: Postmenopause group (n = 109) showed significantly lower BMD score in lumbar spine and femoral neck and significantly higher serum homocysteine concentration compared to premenopause group (n = 300). However, after adjusting for age, body mass index, and the menopausal condition in total 409 women, there were no significant correlations between serum homocysteine levels and BMD. Conclusion: Measurement of serum homocysteine levels may not be useful, but adjunctive for the risk assessment of osteoporosis in middle aged women.
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