환경 중 Thiram에 대한 초기위해성평가
Initial Risk Assessment of Thiram in Environment
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Thiram is a High Production Volume Chemical (HPV), mainly used as vulcanizing agents in the rubber industry, complexing agents and catalyser. In Korea, the production volume is about 604 tonnes/year as of 2006. The aim of this present investigation is to evaluate the toxic potential of thiram for the environment. In this study, Quantitative Structure-Activity Relationships (QSARs) are used to get adequate information on the environment fate and pathways. In water, this substance is rapidly broken down by hydrolysis and photodegradation,especially under acidic conditions. It is not readily biodegradable and has a low bioaccumulation potential. 72 hr-EC_(50) (growth rate) and 72hr-EC_(50) (yield) for algae were 0.19 mg/L, 0.060 mg/L, respectively. The 48hr-EC_(50) for daphnia was 0.036 mg/L and the 96hr-LC_(50) of acute toxicity to fish was 0.17 mg/L. From the acute toxicity value of algae, daphnia and fish, an assessment factor of 100 was used to determine the predicted no effect concentration (PNEC). The PNEC was calculated to be 0.36 μg/L based on the 48hr-EC_(50)daphnia (0.036 mg/L). Based on these data, it is concluded that the substance possesses properties hazardous to the environment. Therefore, environment exposure assessment is recommended.
Abstract
Thiram is a High Production Volume Chemical (HPV), mainly used as vulcanizing agents in the rubber industry, complexing agents and catalyser. In Korea, the production volume is about 604 tonnes/year as of 2006. The aim of this present investigation is to evaluate the toxic potential of thiram for the environment. In this study, Quantitative Structure-Activity Relationships (QSARs) are used to get adequate information on the environment fate and pathways. In water, this substance is rapidly broken down by hydrolysis and photodegradation,especially under acidic conditions. It is not readily biodegradable and has a low bioaccumulation potential. 72 hr-EC_(50) (growth rate) and 72hr-EC_(50) (yield) for algae were 0.19 mg/L, 0.060 mg/L, respectively. The 48hr-EC_(50) for daphnia was 0.036 mg/L and the 96hr-LC_(50) of acute toxicity to fish was 0.17 mg/L. From the acute toxicity value of algae, daphnia and fish, an assessment factor of 100 was used to determine the predicted no effect concentration (PNEC). The PNEC was calculated to be 0.36 μg/L based on the 48hr-EC_(50)daphnia (0.036 mg/L). Based on these data, it is concluded that the substance possesses properties hazardous to the environment. Therefore, environment exposure assessment is recommended.
참고문헌 (15)
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