3D 인공 피부모델을 이용한 화장품 안전성 및 효능 평가 연구
The Safety and Efficacy Evaluation of Cosmetics using 3D Skin Model
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Cosmetics and their raw materials must be safe for consumers under the conditions of use. Safety assessments for some toxicological endpoints and efficacy evaluation of raw materials have relied on animal studies for a long time. However, in addition to animal welfare concerns and regulatory measures, more human-relevant data without animal testing have led to a new approach to safety assessment. As animal testing for safety evaluation of cosmetics and its raw materials is prohibited, various alternative test methods have been developed and used. Recently, interest in efficacy evaluation and safety confirmation systems using artificial skin models as alternative for animal testing is increasing. In this study, latest research trends for alternative animal testing methods for cosmetic safety evaluation were reviewed, and the limitations and directions for improvement of the current alternative animal testing methods were investigated. In addition, the current status of cosmetic efficacy evaluation research using artificial skin model and guidelines for evaluating the functional efficacy of existing cosmetics were investigated.
Abstract
Cosmetics and their raw materials must be safe for consumers under the conditions of use. Safety assessments for some toxicological endpoints and efficacy evaluation of raw materials have relied on animal studies for a long time. However, in addition to animal welfare concerns and regulatory measures, more human-relevant data without animal testing have led to a new approach to safety assessment. As animal testing for safety evaluation of cosmetics and its raw materials is prohibited, various alternative test methods have been developed and used. Recently, interest in efficacy evaluation and safety confirmation systems using artificial skin models as alternative for animal testing is increasing. In this study, latest research trends for alternative animal testing methods for cosmetic safety evaluation were reviewed, and the limitations and directions for improvement of the current alternative animal testing methods were investigated. In addition, the current status of cosmetic efficacy evaluation research using artificial skin model and guidelines for evaluating the functional efficacy of existing cosmetics were investigated.
참고문헌 (30)
- Abbott, A., "Animal testing : more than a cosmetic change", Nature, 438(7065), pp.144~147 (2005)
- Adler, S., "Alternative(non-animal)methods for cosmetics testing : current status and future prospects—2010", Archives of toxicology, 85(5), pp.367~485 (2011)
- Barthe, M., "Safety Testing of Cosmetic Products : Overview of Established Methods and New Approach Methodologies(NAMs)", Cosmetics, 8(2), pp.50~ (2021)
- Bataillon, M., "Characterization of a new reconstructed full thickness skin model, T-Skin™, and its application for investigations of anti-aging compounds", International journal of molecular sciences, 20(9), pp.2240~ (2019)
- Bell, E., "The reconstitution of living skin", Journal of investigative dermatology, 81(1), pp.S2~ (1983)
- Chung, J. H., "Regulations of collagen synthesis by ascorbic acid, transforming growth factor-βand interferon-γ in human dermal fibroblasts cultured in three-dimensional collagen gel are photoaging-and aging"independent", Journal of dermatological science, 15(3), pp.188~200 (1997)
- Cottrez, F., "Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model", Development of the SENS-IS assay. Toxicology in Vitro, 29(4), pp.787~802 (2015)
- D’Mello, S. A., "Signaling pathways in melanogenesis", International journal of molecular sciences, 17(7), pp.1144~ (2016)
- do Nascimento Pedrosa, T., "A new reconstructed human epidermis for in vitro skin irritation testing", Toxicology in Vitro, 42, pp.31~37 (2017)
- Grazul‐Bilska, A., "Antioxidant capacity of 3D human skin EpiDermTM model : effects of skin moisturizers", International journal of cosmetic science, 31(3), pp.201~208 (2009)
- Groeber, F., "Skin tissue engineering—in vivo and in vitro applications", Advanced drug delivery reviews, 63(4-5), pp.352~366 (2011)
- Groeber, F., "Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis(phase II)", Toxicology in Vitro, 36, pp.254~261 (2016)
- Han, J., "Me-too validation study for in vitro skin irritation test with a reconstructed human epidermis model, KeraSkin™ for OECD test guideline 439", Regulatory Toxicology and Pharmacology, 117, pp.104725~ (2020)
- Ishihara, Y., "Melanostatin, a new melanin synthesis inhibitor", The Journal of antibiotics, 44(1), pp.25~32 (1991)
- Kim, D. J., "Anti-aging potential of substance P-based hydrogel for human skin longevity", International journal of molecular sciences, 20(18), pp.4453~ (2019)
- 김규리, "Acremonidin E produced by Penicillium sp. SNF123, a fungal endophyte of Panax ginseng , has antimelanogenic activities", Journal of Ginseng Research, 45(1), pp.98~107 (2021), 고려인삼학회[DOI]
- Krewski, D., "Toxicity testing in the 21st century : implications for human health risk assessment", Risk Analysis : An International Journal, 29(4), pp.474~479 (2009)
- Krupsky, M., "Retinoic acid-induced inhibition of type I collagen gene expression by human lung fibroblasts", Biochimica et Biophysica Acta(BBA)-Gene Structure and Expression, 1219(2), pp.335~341 (1994)
- Küchler, S., "3D-wound healing model : influence of morphine and solid lipid nanoparticles", Journal of biotechnology, 148(1), pp.24~30 (2010)
- Li, Z., "Three-dimensional perfused cell culture", Biotechnology advances, 32(2), pp.243~254 (2014)
- Lotte, C., "Permeation and skin absorption: reproducibility of various industrial reconstructed human skin models", Skin Pharmacology and Physiology, 15(Suppl. 1), pp.18~30 (2002)
- Mewes, K., "Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis(phase I)", Toxicology in Vitro, 36, pp.238~253 (2016)
- Phillips, T. J., "Treatment of skin ulcers with cultured epidermal allografts", Journal of the American Academy of Dermatology, 21(2), pp.191~199 (1989)
- Poumay, Y., "A simple reconstructed human epidermis : preparation of the culture model and utilization in in vitro studies", Archives of dermatological research, 296(5), pp.203~211 (2004)
- Rheinwald, J. G., "Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma", Cell, 6(3), pp.317~330 (1975)
- Rimann, M., "Synthetic 3D multicellular systems for drug development", Current opinion in biotechnology, 23(5), pp.803~809 (2012)
- Song, D., "PAL-12, a new anti-aging hexa-peptoid, inhibits UVB-induced photoaging in human dermal fibroblasts and 3D reconstructed human full skin model, Keraskin-FT™", Archives of dermatological research, 309(9), pp.697~707 (2017)
- Sugimoto, K., "Inhibitory effects of α-arbutin on melanin synthesis in cultured human melanoma cells and a three"dimensional human skin model", Biological Pharmaceutical Bulletin, 27(4), pp.510~514 (2004)
- Vinardell, M. P., "Alternative methods to animal testing for the safety evaluation of cosmetic ingredients : an overview", Cosmetics, 4(3), pp.30~ (2017)
- Wang, Z., "Effects of aloesin on melanogenesis in pigmented skin equivalents", International journal of cosmetic science, 30(2), pp.121~130 (2008)