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Immediate Moderate Intensity Treadmill Exercise After Restraint Stress Induced ERK-mediated Anxiety and Depression

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PURPOSE Chronic stress cause physical and mental function disorders such as anxiety and depression. One of the effective ways to relieve this stress is regular moderate intensity exercise. However effect of exact role of moderate intensity exercise on physical and mental function is not clear. This study aim to investigate the effect of immediate moderate intensity exercise after stress on anxiety, depression-like behavior and motor ability. METHODS Six-week-old male wister rat were divided into three group which were control(CT) group, restraint stress (RS) group and treadmill exercise after restraint stress (EX) group. RS and EX group were subjected to restraint stress (1h/day) for 5 days, while CT group were stay in normal condition. Immediate after restraint stress, EX group were subjected to treadmill-running (30min/day) for 5 days immediate after restraint stress. Free moving tests and open field tests were used to analyze behavior and athletic competence such as anxiety and depression, and phosphorylation levels of ERK were assessed using western blotting of the brain hippocampus. RESULTS In free moving test, freezing time of EX group were increased compared to RS group(p<.05) and CT group(p<.05). On the other hand, Velocity of EX group were decreased compared to RS group(p<.05) and CT group(p<.05). In open field test, velocity, distance and frequency in center of RS group were lower than CT group(p<.05) and EX group were lower than ST group(p<.01). Phosphorylation of ERK were increased on EX group. CONCLUSIONS Immediate moderate intensity treadmill exercise after restraint stress increased anxiety and depression-like behavior and decreased motor ability. Furthermore, the activity of ERK protein associated with stress and depression was increased by immediate exercise after stress. The results suggest that immediate exercise after stress can lead to mental and physical depression.

Abstract

PURPOSE Chronic stress cause physical and mental function disorders such as anxiety and depression. One of the effective ways to relieve this stress is regular moderate intensity exercise. However effect of exact role of moderate intensity exercise on physical and mental function is not clear. This study aim to investigate the effect of immediate moderate intensity exercise after stress on anxiety, depression-like behavior and motor ability. METHODS Six-week-old male wister rat were divided into three group which were control(CT) group, restraint stress (RS) group and treadmill exercise after restraint stress (EX) group. RS and EX group were subjected to restraint stress (1h/day) for 5 days, while CT group were stay in normal condition. Immediate after restraint stress, EX group were subjected to treadmill-running (30min/day) for 5 days immediate after restraint stress. Free moving tests and open field tests were used to analyze behavior and athletic competence such as anxiety and depression, and phosphorylation levels of ERK were assessed using western blotting of the brain hippocampus. RESULTS In free moving test, freezing time of EX group were increased compared to RS group(p<.05) and CT group(p<.05). On the other hand, Velocity of EX group were decreased compared to RS group(p<.05) and CT group(p<.05). In open field test, velocity, distance and frequency in center of RS group were lower than CT group(p<.05) and EX group were lower than ST group(p<.01). Phosphorylation of ERK were increased on EX group. CONCLUSIONS Immediate moderate intensity treadmill exercise after restraint stress increased anxiety and depression-like behavior and decreased motor ability. Furthermore, the activity of ERK protein associated with stress and depression was increased by immediate exercise after stress. The results suggest that immediate exercise after stress can lead to mental and physical depression.

참고문헌 (32)

  1. Babyak, M., "Exercise treatment for major depression : maintenance of therapeutic benefit at 10 months", Psychosomatic Medicine, 62(5), pp.633~638 (2000)
  2. Berton, O., "Essential role of BDNF in the mesolimbic dopamine pathway in social defeat", Stress Science, 311(5762), pp.864~868 (2006)
  3. Blumenthal, J. A., "Effects of exercise training on older patients with major depression", Archives of Internal Medicine, 159(19), pp.2349~2356 (1999)
  4. Carver C. S, "Assessing coping strategies : a theoretical based approach", Journal of Personality and Social Psychology, 56, pp.267~283 (1989)
  5. Christakis, D. A., "Overstimulation of newborn mice leads to behavioral differences and deficits in cognitive performance", Scientific Reports, 2, pp.546~ (2012)
  6. Craft, L., "The benefits of exercise for the clinically depressed", Primary Care Companion to the Journal of clinical Psychiatry, 6(3), pp.104~111 (2004)
  7. Duman, R. S., "A neurotrophic model for Stress-related mood disorders", Biological Psychiatry, 59(12), pp.1116~1127 (2006)
  8. Dulawa, S. C., "Effects of Chronic Fluoxetine in Animal Models of Anxiety and Depression", Neuropsychopharmacology, 29(7), pp.1321~1330 (2004)
  9. Einat, H., "The role of the extracellular signal-regulated kinase signaling pathway in mood modulation", Journal of Neuroscience, 23(19), pp.7311~7316 (2003)
  10. Erickson, K. I., "Aerobic exercise effects on cognitive and neural plasticity in older adults", British Journal of Sports Medicine, 43, pp.22~24 (2009)
  11. Fasting, K., "Leisure Time Physical activity and some indices of mental health", Scandinavian Journal of Social Medicine, 29, pp.113~119 (1982)
  12. Ferrer, I., "Early modifications in the expression of mitogen-activated protein kinase(MAPK", ERK), stress-activated kinases SAPK, Acta Neuropathologica, pp.2003, 105(5)[DOI]
  13. Fordyce, D. E., "Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL", 6 and DBA, Brain Research, pp.1993, 619(1-2)[DOI]
  14. Greenwood, B. N., "Freewheel running prevents learned helplessness", behavioral depression : role of dorsal raphe serotonergic neurons, 2003, pp.23(7), 2889~2898
  15. Hayley, S., "stress and cytokine-elicited neuroendocrine and neurotransmitter sensitization Implication for depressive illness", Stress, 6, pp.19~32 (2003)
  16. Kempermann, G., "Activity-dependent regulation of neuronal plasticity and self repair", Progress in Brain Research, 127, pp.35~48 (2000)
  17. 김은경, "Effect of postnatal treadmill running on the serotonin expression in the raphe nuclei of rat pups born from the maternal rats exposed to noise during pregnancy", 한국체육과학회지, 17(4), pp.1157~1168 (2008), 한국체육과학회
  18. Leão, R. M., "Stress induces behavioral sensitization, increases nicotine-seeking behavior and leads to a decrease of CREB in the nucleus accumbens", Pharmacology Biochemistry and Behavior, 101(3), pp.434~442 (2012)
  19. Matheny K. B., "Stress Coping : a Qualitative and quantitative synthesis with implications for treatment", The Counseling Psychologist, 14, pp.499~549 (1986)
  20. Mead G. E, "Exercise for depression", The Cochrane Database of Systematic Reviews, 8(4), pp.121~129 (2008)
  21. Miché, M., "Mental disorders and the risk for the subsequent first suicide attempt: results of a community study on adolescents and young adults", European Child & Adolescent Psychiatry, 219(26), pp.135~143 (2017)
  22. Moraska, A., "Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats", American Journal of Physiology Regulatory, Integrative and Comparative Physiology, 279(4), pp.1321~1329 (2000)
  23. Oh, J. J., "The relationship between stress and life styles in businessman", Journal of the Korean Academy of Family Medicine, 19(4), pp.394~404 (1998)
  24. Pacak, K., "Stressor specificity of central neuroendocrine responses : Implications for stress-related disorders", Endocrine Reviews, 22(4), pp.502~548 (2001)
  25. Reichardt, L. F, "Neurotrophin-regulated signalling pathways", Philosophical Transactions of the Royal Society B Biological Sciences, 361(1473), pp.1545~1564 (2006)
  26. Revest, J. M., "BDNF-TrkB signaling through Erk1", 2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids, 2014, pp.19(9), 1001~1009
  27. Ruscheweyh, R., "Physical activity and memory functions : and interventional study", Neurobiology of Aging, 32, pp.1304~1319 (2011)
  28. Ross, C. E., "Exercise and psychologic well-being in the community", American Journal of Epidemiology, 127(4), pp.762~771 (1988)
  29. Sierles, F. S., "Posttraumatic stress disorder and concurrent psychiatric illness : a preliminary report", The American Journal of Psychiatry, 140, pp.1177~1179 (1983)
  30. Smith, M. S., "Evaluation and management of psychosomatic symptoms in adolescence", Clinical Pediatrics, 25(3), pp.131~135 (1986)
  31. Strekalova, T., "Stress-induced hyperlocomotion as a confounding factor in anxiety and depression models in mice", Behavior Pharmacology, 16(3), pp.171~180 (2005)
  32. Van Praag, H., "Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus", Nature Neuroscience, 2(3), pp.266~270 (1999)

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