Change of Antibiotic Resistance to the Causative Organisms of Pelvic Wound Infection for Recent 5 Years
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: We researched microbial profiles and the antimicrobial resistance profile of wound infection of the pelvic area in Korea for the recent 5 years in order to provide useful information on the choice of adequate drugs in the treatment of pelvic wound infection.Materials and Methods: We retrospectively analyzed 211 pelvic wound culture samples and their antimicrobial resistance in 198 in- or out-patients of the Urology and Plastic surgery department from January 2010 to December 2014.Results: Of the total samples, Staphylococcus aureus was isolated most frequently (35.3%), followed by Escherichia coli (15.1%), Staphylococcus epidermidis (12.6%), Staphylococcus haemolyticus (12.6%), Staphylococcus lugdunensis (8.4%), Pseudomonas aeruginosa (6.7%), Enterococcus spp. (4.2%), and Streptococcus spp. (3.3%). There were no notable changes of bacterial distribution for 5 years. For Gram-positive isolates, the oxacillin resistance rate for Gram-positive bacteria was 42.6% and showed an increasing tendency for the recent 5 years. Piperacillin, rifampicin, and vancomycin had low resistance for Gram-positive bacteria. Carbapenems, piperacillin/tazobactam had low resistance for Gram-negative bacteria. The Gram-positive organisms were more sensitive to many antibiotics in contrast to the Gram-negative organisms. Conclusions: Of varied causative organisms and susceptibility of the pelvic wound site, the most frequently infected organisms of the pelvic area were S. aureus, followed by E. coli. The methicillin resistive S. aureus (MRSA) incidence showed a tendency to increase yearly, thus selection or early change of antibiotics considering MRSA is recommended if the antibiotic response is poor. Gram-negative bacteria has a higher resistance rate compared with Gram-positive bacteria and had carbapenems and piperacillin/tazobactam.
Abstract
Purpose: We researched microbial profiles and the antimicrobial resistance profile of wound infection of the pelvic area in Korea for the recent 5 years in order to provide useful information on the choice of adequate drugs in the treatment of pelvic wound infection.Materials and Methods: We retrospectively analyzed 211 pelvic wound culture samples and their antimicrobial resistance in 198 in- or out-patients of the Urology and Plastic surgery department from January 2010 to December 2014.Results: Of the total samples, Staphylococcus aureus was isolated most frequently (35.3%), followed by Escherichia coli (15.1%), Staphylococcus epidermidis (12.6%), Staphylococcus haemolyticus (12.6%), Staphylococcus lugdunensis (8.4%), Pseudomonas aeruginosa (6.7%), Enterococcus spp. (4.2%), and Streptococcus spp. (3.3%). There were no notable changes of bacterial distribution for 5 years. For Gram-positive isolates, the oxacillin resistance rate for Gram-positive bacteria was 42.6% and showed an increasing tendency for the recent 5 years. Piperacillin, rifampicin, and vancomycin had low resistance for Gram-positive bacteria. Carbapenems, piperacillin/tazobactam had low resistance for Gram-negative bacteria. The Gram-positive organisms were more sensitive to many antibiotics in contrast to the Gram-negative organisms. Conclusions: Of varied causative organisms and susceptibility of the pelvic wound site, the most frequently infected organisms of the pelvic area were S. aureus, followed by E. coli. The methicillin resistive S. aureus (MRSA) incidence showed a tendency to increase yearly, thus selection or early change of antibiotics considering MRSA is recommended if the antibiotic response is poor. Gram-negative bacteria has a higher resistance rate compared with Gram-positive bacteria and had carbapenems and piperacillin/tazobactam.
참고문헌 (27)
- Leaper DJ, "Wounds: biology and management" (1998), Oxford University Press
- Bowler PG, "Wound microbiology and associated approaches to wound management", Clin Microbiol Rev, 14, pp.244~269 (2001)
- Forbes BA, "Bailey & Scott’s diagnostic microbiology", pp.972~984 (1998), Mosby
- Dykhuizen RS, "An analysis of 900 consecutive admissions to a regional infection unit", J Infect, 29, pp.189~193 (1994)
- Bannister BA, "Infectious disease", pp.76~102 (1996), Blackwell Science
- Finch R, "Skin and soft-tissue infections", Lancet, 1, pp.164~168 (1988)
- Sands K, "Surgical site infections occurring after hospital discharge", J Infect Dis, 173, pp.963~970 (1996)
- Garner JS, "CDC guideline for prevention of surgical wound infections, 1985. Supersedes guideline for prevention of surgical wound infections published in 1982. (Originally published in November 1985). Revised", Infect Control, 7, pp.193~200 (1986)
- Gaynes RP, "Surgical site infection (SSI) rates in the United States, 1992-1998: the National Nosocomial Infections Surveillance System basic SSI risk index", Clin Infect Dis, 33(Suppl 2), pp.S69~S77 (2001)
- Lee MS, "Characteriscs of methicillin-resistant Staphylococcus aureus isolated from wounds in Korean patients", J Infect Chemother, 2, pp.130~135 (1996)
- 김정만, "비뇨기과 주요 수술 후 발생한 창상 파열과 MRSA균 감염과의 관계", Investigative and Clinical Urology, 47(3), pp.298~302 (2006), 대한비뇨기과학회
- 이재혁, "외과 환자의 수술창 감염에 대한 전향적인 연구", 대한외과학회지, 66(02), pp.133~137 (2004), 대한외과학회
- Kim DW, "Risk factors and prognostic influences of burn wound infection", J Korean Surg Soc, 61, pp.195~202 (2001)
- Pondei K, "Current microbial isolates from wound swabs, their culture and sensitivity pattern at the niger delta university teaching hospital, okolobiri, Nigeria", Trop Med Health, 41, pp.49~53 (2013)
- Basu S, "A prospective, descriptive study to identify the microbiological profile of chronic wounds in outpatients", Ostomy Wound Manage, 55, pp.14~20 (2009)
- Gupta AK, "Microbial epidemiology and antimicrobial susceptibility profile of wound infections in out-patients at a level 1 trauma centre", J Patient Saf Infect Control (2015)[DOI]
- Wariso BA, "A survey of common pathogens in wound in patients at the University of Port Harcourt Teaching Hospital (U.P.T.H), Port Harcourt", West Afr J Med, 22, pp.50~54 (2003)
- Phillips J, "Prevention of surgical site infections", Surgery, 32, pp.468~471 (2014)
- Kim JM, "A single center study of the change of antibiotic resistance to the causative organisms of urinary tract infection for recent 10 years", Korean J Urogenit Tract Infect Inflamm, 3, pp.63~74 (2008)
- Hooton TM, "Diagnosis and treatment of uncomplicated urinary tract infection", Infect Dis Clin North Am, 11, pp.551~581 (1997)
- Jones ME, "Epidemiology and antibiotic susceptibility of bacteria causing skin and soft tissue infections in the USA and Europe: a guide to appropriate antimicrobial therapy", Int J Antimicrob Agents, 22, pp.406~419 (2003)
- Kaul R, "Population-based surveillance for group A streptococcal necrotizing fasciitis: clinical features, prognostic indicators, and microbiologic analysis of seventy-seven cases. Ontario Group A Streptococcal Study", Am J Med, 103, pp.18~24 (1997)
- Moet GJ, "Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY Antimicrobial Surveillance Program (1998-2004)", Diagn Microbiol Infect Dis, 57, pp.7~13 (2007)
- 최성호, "연부조직 감염 진료지침 권고안", Infection and Chemotherapy, 44(4), pp.213~232 (2012), 대한감염학회
- Goswami NN, "Antibiotic sensitivity profile of bacterial pathogens in postoperative wound infections at a tertiary care hospital in Gujarat, India", J Pharmacol Pharmacother, 2, pp.158~164 (2011)
- Giacometti A, "Epidemiology and microbiology of surgical wound infections", J Clin Microbiol, 38, pp.918~922 (2000)
- Gustafson TL, "Pseudomonas folliculitis: an outbreak and review", Rev Infect Dis, 5, pp.1~8 (1983)