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六君子湯이 흰쥐의 胃 排出能에 미치는 영향

Effect of Yukgunjatang Granule on Gastric Emptying in Rats

윤상협|원종만
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2007.06|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제28권 제2호|pp. 242-249

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Abstract

Backgrounds & Objectives : Yukgunjatanggranule (YGJT) has been used for the treatment of functional dyspepsia, regarded as one of the gastric dysmotility diseases, but its mechanisms of action are not yet well known. We investigated the effects of YGJT on gastric emptying and its mechanisms of action in rats. Methods : Gastric emptying was measured by glass beads (1mm in diameter) expelled from the stomach for 1 hour and 2 hours after administration ofnormal saline (NS) or YGJT 41.6mg/kg or 124.8mg/kg in rats. By the same method, gastric emptying was measured only for 2 hours after administration of NS or YGJT 124.8mg/kg in rats treated with atropine sulfate (1mg/kg, s.c.), quinpirole HCl(0.3mg/kg, i.p.), NAME (NG-nitro-L-arginine methyl ester, 75mg/kg, s.c.) or cisplatin (10mg/kg, i.p.) to delay gastric emptying. Results : YGJT 124.8mg/kg improved gastric emptying more than NS or YGJT 41.6mg/kg (p=0.046). Under delayed gastric emptying, YGJT 124.8mg/kg improved gastric emptying in the group treated with cisplatin (3.1±1.3 vs. 6.6±3.1, p=0.015), quinpirole HCl (4.7±2.8 vs. 5.5±5.6, p=0.874) and NAME (2.2±1.4 vs. 4.7±6.0, p=0.414), but aggravated it with atropine sulfate (1.8±0.9 vs. 1.7±1.0, p=0.957). Conclusions : YGJT improves gastric emptying through the cholinergic pathway, and shows some effect against the toxicity of cisplatin. Therefore, we expect that it would be effective in relieving gastrointestinal symptoms in functional dyspepsia patients and cisplatin-treated patients.

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