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흰쥐의 胃 排出能에 대한 半夏瀉心湯의 效能

Effect of Banhasasimtang Granule on Gastric Emptying in Rats

윤상협|김진성|류봉하|이준석
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2006.06|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제27권 제2호|pp. 471-479

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Abstract

Backgrounds & Objectives: Banhasasimtang granule(BHSST) has been used for the treatment of functional dyspepsia regarded as one of the gastric dysmotility disease. but its mechanisms of action are not well known yet. So we investigated the effects of BHSST on gastric emptying and its mechanisms of action in rats. Methods: Gastric emptying was measured by glass beads(1mm in diameter) expelled from the stomach for 60 min after administration of normal saline(NS) or BHSST 31mg/kg or 93mg/kg in rats. And by the same method gastric emptying was measured after administration of NS or BHSST 93mg/kg in rats treated with atropine sulfate(1mg/kg, s.c.), quinpirol HCl(0.3mg/kg, i.p.), NAME(NG-nitro-L-arginine methyl ester, 75mg/kg, s.c.) or cisplatin(10mg/kg, i.p.) to make delayed gastric emptying. Results: BHSST 93mg/kg improved gastric emptying more than NS or BHSST 31mg/kg(p=0.016). Under the delayed gastric emptying, BHSST 93mg/kg improved gastric emptying in the group treated with NAME(5.00±3.101 vs 9.00±3.51, p=0.046), but aggravated it with atropine sulfate(5.71±3.45 vs 2.57±1.62, p=0.050) and cisplatin(12.71±2.29 vs 8.57±5.06, p=0.072). Conclusions: BHSST improves the gastric emptying through cholinergic and 5-hydroxytryptamine 3 receptors. Especially it is effective to improve gastric emptying delayed by NAME. So we expect that it would be effective in functional dyspepsia with impaired reservoir functions such as gastric adaptive relaxation.

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