Impacts of Senolytic Phytochemicals on Gut Microbiota: A Comprehensive Review

키워드

참고문헌 (53)

1. Lopes-Paciencia S, "The senescence-associated secretory phenotype and its regulation", Cytokine, 117, pp.15~22 (2019)
2. Lujambio A, "Non-cell-autonomous tumor suppression by p53", Cell, 153, pp.449~460 (2013)
3. Gasek NS, "Strategies for targeting senescent cells in human disease", Nat. Aging, 1, pp.870~879 (2021)
4. Chandeck C, "Oncogene-induced cellular senescence", Adv. Anat. Pathol, 17, pp.42~48 (2010)
5. Nousis L, "Oxidative stress-induced cellular senescence: is labile iron the connecting link?", Antioxidants (Basel), 12, pp.1250~ (2023)
6. Miwa S, "Mitochondrial dysfunction in cell senescence and aging", J. Clin. Invest, 132, pp.e158774~ (2022)
7. Peng X, "Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem", progenitor cell niche, 2020, pp.11, 854~
8. Guillon J, "Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneity", Cell Cycle, 18, pp.2385~2397 (2019)
9. Soto-Gamez A, "Regulation of survival networks in senescent cells : From mechanisms to interventions", J. Mol. Biol, 431, pp.2629~2643 (2019)
10. Hickson LJ, "Senolytics decrease senescent cells in humans : preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease", EBioMedicine, 47, pp.446~456 (2019)
11. Chen J, "The cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression", Cold Spring Harb. Perspect. Med, 6, pp.a026104~ (2016)
12. Seluanov A, "Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53", Mol. Cell Biol, 21, pp.1552~1564 (2001)
13. Zhu Y, "The Achilles' heel of senescent cells : from transcriptome to senolytic drugs", Aging Cell, 14, pp.644~658 (2015)
14. Fuhrmann-Stroissnigg H, "Identification of HSP90 inhibitors as a novel class of senolytics", Nat. Commun, 8, pp.422~ (2017)
15. Zhu Y, "Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors", Aging Cell, 15, pp.428~435 (2016)
16. Zhu Y, "New agents that target senescent cells : the flavone, fisetin, and the BCL-X(L)inhibitors, A1331852 and A1155463", Aging(Albany NY), 9, pp.955~963 (2017)
17. Huang B, "Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3", Aging(Albany NY), 1, pp.845~854 (2009)
18. Baar MP, "Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging", Cell, 169, pp.132~147 (2017)
19. Nogueira V, "Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis", Cancer Cell, 14, pp.458~470 (2008)
20. Schlessinger J, "New roles for Src kinases in control of cell survival and angiogenesis", Cell, 100, pp.293~296 (2000)
21. Anerillas C, "Early SRC activation skews cell fate from apoptosis to senescence", Sci. Adv, 8, pp.eabm0756~ (2022)
22. Rivera-Torres J, "Src tyrosine kinase inhibitors: new perspectives on their immune, antiviral, and senotherapeutic potential", Front. Pharmacol, 10, pp.1011~ (2019)
23. Fuhrmann-Stroissnigg H, "Hsp90 inhibitors as senolytic drugs to extend healthy aging", Cell Cycle, 17, pp.1048~1055 (2018)
24. Geng X, "Cardiac glycosides inhibit cancer through Na", K-ATPase-dependent cell death induction, 2020, pp.182, 114226~
25. Oliver PL, "Oxr1 is essential for protection against oxidative stressinduced neurodegeneration", PLoS Genet, 7, pp.e1002338~ (2011)
26. Yang M, "Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21", Free Radic. Biol. Med, 77, pp.41~48 (2014)
27. Wang R, "Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism", Aging Cell, 16, pp.564~574 (2017)
28. Maduro AT, "Ageing, cellular senescence and the impact of diet : an overview", Porto Biomed J, 6, pp.e120~ (2021)
29. Hwang HV, "Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells", PLoS One, 13, pp.e0190374~ (2018)
30. Yousefzadeh MJ, "Fisetin is a senotherapeutic that extends health and lifespan", EBioMedicine, 36, pp.18~28 (2018)
31. Malavolta M, "Pleiotropic effects of tocotrienols and quercetin on cellular senescence : Introducing the perspective of senolytic effects of phytochemicals", Curr. Drug Targets, 17, pp.447~459 (2016)
32. Ota H, "Dasatinib plus quercetin attenuates some frailty characteristics in SAMP10 mice", Sci. Rep, 12, pp.2425~ (2022)
33. Justice JN, "Senolytics in idiopathic pulmonary fibrosis : Results from a first-in-human, open-label, pilot study", EBioMedicine, 40, pp.554~563 (2019)
34. Currais A, "Fisetin reduces the impact of aging on behavior and physiology in the rapidly aging SAMP8 mouse", J. Gerontol. A Biol. Sci. Med. Sci, 73, pp.299~307 (2018)
35. Li W, "The curcumin analog EF24 is a novel senolytic agent", Aging(Albany NY), 11, pp.771~782 (2019)
36. Kumar R, "Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K", Akt, Bcl-2 pathway, pp.Biogerontology, 2019[DOI]
37. Xu Q, "The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice", Nat. Metab, 3, pp.1706~1726 (2021)
38. Moaddel R, "Identification of gingerenone A as a novel senolytic compound", PLoS One, 17, pp.e0266135~ (2022)
39. Varela-Eirin M, "Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis", Aging(Albany NY), 12, pp.15882~15905 (2020)
40. Zheng D, "Interaction between microbiota and immunity in health and disease", Cell Res, 30, pp.492~506 (2020)
41. Hohman LS, "A gut-centric view of aging: Do intestinal epithelial cells contribute to age-associated microbiota changes, inflammaging, and immunosenescence?", Aging Cell, 21, pp.e13700~ (2022)
42. Walrath T, "Age-related changes in intestinal immunity and the microbiome", J. Leukoc. Biol, 109, pp.1045~1061 (2021)
43. Ren J, "Gut microbiome-mediated mechanisms in aging-related diseases : are probiotics ready for prime time?", Front. Pharmacol, 14, pp.1178596~ (2023)
44. Stebegg M, "Heterochronic faecal transplantation boosts gut germinal centres in aged mice", Nat. Commun, 10, pp.2443~ (2019)
45. Saccon TD, "Senolytic combination of dasatinib and quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice", J. Gerontol. A Biol. Sci. Med. Sci, 76, pp.1895~1905 (2021)
46. Ashiqueali SA, "Fisetin modulates the gut microbiota alongside biomarkers of senescence and inflammation in a DSS-induced murine model of colitis", Geroscience, 46, pp.3085~3103 (2024)
47. Wei R, "Chlorogenic acid combined with epigallocatechin-3-gallate mitigates D-galactose-induced gut aging in mice", Food Funct, 14, pp.2684~2697 (2023)
48. Sharma R, "Long-term consumption of green tea EGCG enhances murine health span by mitigating multiple aspects of cellular senescence in mitotic and post-mitotic tissues, gut dysbiosis, and immunosenescence", J. Nutr. Biochem, 107, pp.109068~ (2022)
49. Wang X, "Procyanidin C1 modulates the microbiome to increase FOXO1 signaling and valeric acid levels to protect the mucosal barrier in inflammatory bowel disease", Engineering (2024)[DOI]
50. Zhao Q, "Akkermansia muciniphila plays critical roles in host health", Crit Rev Microbiol, 49, pp.82~100 (2023)
51. Chen TJ, "Fisetin regulates gut microbiota and exerts neuroprotective effect on mouse model of Parkinson's disease", Front. Neurosci, 14, pp.549037~ (2020)
52. Huang S, "Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus", Sci. Adv, 9, pp.eadi7337~ (2023)
53. Sharma R, "Emerging interrelationship between the gut microbiome and cellular senescence in the context of aging and disease : perspectives and therapeutic opportunities", Probiotics Antimicrob. Proteins, 14, pp.648~663 (2022)

관련 논문AI추천