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Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis

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초록

Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity.

Abstract

Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity.

참고문헌 (50)

  1. Chung HY, "Molecular inflammation : underpinnings of aging and age-related diseases", Ageing Res Rev, 8, pp.18~30 (2009)
  2. Chung HY, "Redefining Chronic Inflammation in Aging and Age-Related Diseases:Proposal of the Senoinflammation Concept", Aging Dis (2018)
  3. Vasto S, "Inflammatory networks in ageing, age-related diseases and longevity", Mech Ageing Dev, 128, pp.83~91 (2007)
  4. Yu BP, "Critical evaluation of the free radical theory of aging. A proposal for the oxidative stress hypothesis", Ann N Y Acad Sci, 786, pp.1~11 (1996)
  5. Groslambert M, "Spotlight on the NLRP3inflammasome pathway", J Inflamm Res, 11, pp.359~374 (2018)
  6. Hanouna G, "Specific calpain inhibition protects kidney against inflammaging", Sci Rep, 7, pp.8016~ (2017)
  7. Baker DJ, "Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan", Nature, 530, pp.184~189 (2016)
  8. Salminen A, "Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype(SASP)", Cell Signal, 24, pp.835~845 (2012)
  9. Young AR, "SASP reflects senescence", EMBO Rep, 10, pp.228~230 (2009)
  10. Coppe JP, "Senescenceassociated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor", PLoS Biol, 6, pp.2853~2868 (2008)
  11. Freund A, "Inflammatory networks during cellular senescence : causes and consequences", Trends Mol Med, 16, pp.238~246 (2010)
  12. Seo YH, "Enhanced glycogenesis is involved in cellular senescence via GSK3", GS modulation, 2008, pp.7, 894~907
  13. Coppe JP, "The senescence-associated secretory phenotype : the dark side of tumor suppression", Annu Rev Pathol, 5, pp.99~118 (2010)
  14. Georgilis A, "PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells", Cancer Cell, 34, pp.85~102 (2018)[DOI]
  15. Fuhrmann-Stroissnigg H, "Hsp90 inhibitors as senolytic drugs to extend healthy aging", Cell Cycle, 17, pp.1048~1055 (2018)
  16. Redman LM, "Caloric restriction in humans : impact on physiological, psychological, and behavioral outcomes", Antioxid Redox Signal, 14, pp.275~287 (2011)
  17. Gonzalez O, "Caloric restriction and chronic inflammatory diseases", Oral Dis, 18, pp.16~31 (2012)
  18. Anderson RM, "The caloric restriction paradigm : implications for healthy human aging", Am J Hum Biol, 24, pp.101~106 (2012)
  19. Nadon NL, "Design of aging intervention studies: the NIA interventions testing program", Age (Dordr), 30, pp.187~199 (2008)
  20. Mattson MP, "Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment : molecular mechanisms", Mech Ageing Dev, 122, pp.757~778 (2001)
  21. Cohen DE, "Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction", Genes Dev, 23, pp.2812~2817 (2009)
  22. Pahlavani MA, "Caloric restriction and immunosenescence : a current perspective", Front Biosci, 5, pp.D580~D587 (2000)
  23. Kurki E, "Distinct effects of calorie restriction on adipose tissue cytokine and angiogenesis profiles in obese and lean mice", Nutr Metab (Lond), 9, pp.64~ (2012)
  24. Lijnen HR, "Caloric restriction improves coagulation and inflammation profile in obese mice", Thromb Res, 129, pp.74~79 (2012)
  25. 최원희, "Cooked Rice Inhibits Hepatic Fat Accumulation by Regulating Lipid Metabolism–Related Gene Expression in Mice Fed a High-Fat Diet", Journal of Medicinal Food, 17(1), pp.36~42 (2014), 한국식품영양과학회[DOI]
  26. Jung KJ, "Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney", Inflamm Res, 58, pp.143~150 (2009)
  27. Sadagurski M, "Transient early food restriction leads to hypothalamic changes in the long-lived crowded litter female mice", Physiol Rep, 3, pp.e12379~ (2015)
  28. Tsutsumi A, "Caloric restriction decreases ER stress in liver and adipose tissue in ob", ob mice, 2011, pp.404, 339~344
  29. Escriva F, "Effect of age and moderate food restriction on insulin sensitivity in Wistar rats : role of adiposity", J Endocrinol, 194, pp.131~141 (2007)
  30. Zheng Y, "Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats", J Endocrinol, 203, pp.337~347 (2009)
  31. Park MH, "Potent anti-diabetic effects of MHY908, a newly synthesized PPAR alpha", gamma dual agonist in db, PLoS One, pp.2013, 8[DOI]
  32. Youm YH, "The ketone metabolite beta-hydroxybutyrate blocks NLRP3inflammasome-mediated inflammatory disease", Nat Med, 21, pp.263~269 (2015)
  33. Fann DY, "Intermittent fasting attenuates inflammasome activity in ischemic stroke", Exp Neurol, 257, pp.114~119 (2014)
  34. Traba J, "Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects", J Clin Invest, 125, pp.4592~4600 (2015)
  35. Chung KW, "Recent advances in calorie restriction research on aging", Exp Gerontol, 48, pp.1049~1053 (2013)
  36. Kim HJ, "Modulation of redox-sensitive transcription factors by calorie restriction during aging", Mech Ageing Dev, 123, pp.1589~1595 (2002)
  37. Sung B, "Modulation of PPAR in aging, inflammation, and calorie restriction", J Gerontol A Biol Sci Med Sci, 59, pp.997~1006 (2004)
  38. Delerive P, "Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators", J Biol Chem, 275, pp.36703~36707 (2000)
  39. Chung SW, "Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B", J Biol Chem, 275, pp.32681~32687 (2000)
  40. Chung JH, "Molecular mechanism of PPAR in the regulation of age-related inflammation", Ageing Res Rev, 7, pp.126~136 (2008)
  41. Satoh A, "Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH", Cell Metab, 18, pp.416~430 (2013)
  42. Nisoli E, "Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS", Science, 310, pp.314~317 (2005)
  43. Frescas D, "Nuclear trapping of the forkhead transcription factor FoxO1 via Sirtdependent deacetylation promotes expression of glucogenetic genes", J Biol Chem, 280, pp.20589~20595 (2005)
  44. Hong SE, "Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome", Age (Dordr), 32, pp.15~30 (2010)
  45. Park D, "Identification of the dichotomous role of age-related LCK in calorie restriction revealed by integrative analysis of cDNA microarray and interactome", Age (Dordr), 35, pp.1045~1060 (2013)
  46. Park D, "RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney", Oncotarget, 7, pp.30037~30048 (2016)
  47. He S, "Senescence in Health and Disease", Cell, 169, pp.1000~1011 (2017)
  48. Kim CH, "Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation", Aging Cell, 15, pp.1074~1081 (2016)
  49. 박민희, "Age-related inflammation and insulin resistance: a review of their intricate interdependency", Archives of Pharmacal Research, 37(12), pp.1507~1514 (2014), 대한약학회
  50. Kim DH, "The activation of NF-kappaB through Akt-induced FOXO1phosphorylation during aging and its modulation by calorie restriction", Biogerontology, 9, pp.33~47 (2008)

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