Effect of Oxcarbazepine on Language Function in Patients With Newly Diagnosed Pediatric Epilepsy
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background and Purpose This study aimed to determine the effects of oxcarbazepine (OXC) on the language function of patients with pediatric epilepsy. Methods We assessed the language abilities of patients aged 5–17 years with newly diagnosed focal epilepsy and the same number of age-matched healthy children using the Test of Problem Solving (TOPS) and the Receptive and Expressive Vocabulary Test–Receptive (REVT-R). The Mean Length of Utterance–words (MLU-w) was used to estimate linguistic productivity before and after OXC initiation. All patients received OXC monotherapy with a starting dosage of 10 mg/kg/day for 1 week, which in some cases was increased to 30 mg/kg/ day (or 1,200 mg/day). Results The study finally included 41 pediatric patients (22 males and 19 females; age 9.9±3.0 years, mean±standard deviation). All language parameters of the TOPS improved significantly after initiating OXC (determining cause, 12.5±4.8–13.7±4.1 [p=0.016]; making inference, 15.6±5.6–17.4±6.4 [p<0.001]; and predicting, 9.8±5.0–11.6±4.5 [p=0.001]). However, patients who received OXC did not exhibit a significantly extended MLU-w (determining cause, p=0.493; making inference, p=0.386; and predicting, p=0.341). Receptive language scores also significantly increased after taking OXC (REVT-R: 121.0±43.1–129.4±43.8, p=0.002), but the percentage of development age to chronological age did not vary (REVT-developmental quotient: p=0.075). Conclusions Our results suggest that OXC is safe and preserves language function in patients with pediatric epilepsy.
Abstract
Background and Purpose This study aimed to determine the effects of oxcarbazepine (OXC) on the language function of patients with pediatric epilepsy. Methods We assessed the language abilities of patients aged 5–17 years with newly diagnosed focal epilepsy and the same number of age-matched healthy children using the Test of Problem Solving (TOPS) and the Receptive and Expressive Vocabulary Test–Receptive (REVT-R). The Mean Length of Utterance–words (MLU-w) was used to estimate linguistic productivity before and after OXC initiation. All patients received OXC monotherapy with a starting dosage of 10 mg/kg/day for 1 week, which in some cases was increased to 30 mg/kg/ day (or 1,200 mg/day). Results The study finally included 41 pediatric patients (22 males and 19 females; age 9.9±3.0 years, mean±standard deviation). All language parameters of the TOPS improved significantly after initiating OXC (determining cause, 12.5±4.8–13.7±4.1 [p=0.016]; making inference, 15.6±5.6–17.4±6.4 [p<0.001]; and predicting, 9.8±5.0–11.6±4.5 [p=0.001]). However, patients who received OXC did not exhibit a significantly extended MLU-w (determining cause, p=0.493; making inference, p=0.386; and predicting, p=0.341). Receptive language scores also significantly increased after taking OXC (REVT-R: 121.0±43.1–129.4±43.8, p=0.002), but the percentage of development age to chronological age did not vary (REVT-developmental quotient: p=0.075). Conclusions Our results suggest that OXC is safe and preserves language function in patients with pediatric epilepsy.
참고문헌 (40)
- Afzal KI, "The effects of antiepileptic drugs on pediatric cognition, mood, and behavior", J Pediatr Epilepsy, 6, pp.3~18 (2017)
- Loring DW, "Cognitive side effects of antiepileptic drugs in children", Neurology, 62, pp.872~877 (2004)
- Doo JW, "Influence of valproate on language functions in children with epilepsy", Epilepsy Behav, 78, pp.68~72 (2018)
- Vlooswijk MC, "Functional connectivity and language impairment in cryptogenic localization-related epilepsy", Neurology, 75, pp.395~402 (2010)
- Parkinson GM, "High incidence of language disorder in children with focal epilepsies", Dev Med Child Neurol, 44, pp.533~537 (2002)
- Bailey K, "Language measurement in childhood epilepsy : a review", Brain Lang, 217, pp.104940~ (2021)
- Rho JM, "Brief history of anti-seizure drug development", Epilepsia Open, 3(Suppl 2), pp.114~119 (2018)
- Ijff DM, "Cognitive side-effects of antiepileptic drugs in children", Handb Clin Neurol, 111, pp.707~718 (2013)
- Besag FMC, "Neurocognitive effects of antiseizure medications in children and adolescents with epilepsy", Paediatr Drugs, 23, pp.253~286 (2021)
- Callisto SP, "Severity of topiramate-related working memory impairment is modulated by plasma concentration and working memory capacity", J Clin Pharmacol, 60, pp.1166~1176 (2020)
- Pandina GJ, "Cognitive effects of topiramate in migraine patients aged 12 through 17 years", Pediatr Neurol, 42, pp.187~195 (2010)
- Moavero R, "Cognitive and behavioral effects of new antiepileptic drugs in pediatric epilepsy", Brain Dev, 39, pp.464~469 (2017)
- Schachter SC, "Oxcarbazepine : current status and clinical applications", Expert Opin Investig Drugs, 8, pp.1103~1112 (1999)
- Beydoun A, "Current role of carbamazepine and oxcarbazepine in the management of epilepsy", Seizure, 83, pp.251~263 (2020)
- Donati F, "Effects of oxcarbazepine on cognitive function in children and adolescents with partial seizures", Neurology, 67, pp.679~682 (2006)
- Kim SM, "Effect of oxcarbazepine on background EEG activity and cognition in epilepsy", J Epilepsy Res, 3, pp.7~15 (2013)
- Suo GH, "Effects of levetiracetam and oxcarbazepine monotherapy on intellectual and cognitive development in children with benign epilepsy with centrotemporal spikes", Acta Neurol Belg, 121, pp.1265~1273 (2021)
- Mecarelli O, "Clinical, cognitive, and neurophysiologic correlates of shortterm treatment with carbamazepine, oxcarbazepine, and levetiracetam in healthy volunteers", Ann Pharmacother, 38, pp.1816~1822 (2004)
- Salinsky MC, "Effects of oxcarbazepine and phenytoin on the EEG and cognition in healthy volunteers", Epilepsy Behav, 5, pp.894~902 (2004)
- Husebye ESN, "Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero-the Norwegian Mother and Child Cohort Study", Eur J Neurol, 27, pp.667~675 (2020)
- Arif H, "Patient-reported cognitive side effects of antiepileptic drugs : predictors and comparison of all commonly used antiepileptic drugs", Epilepsy Behav, 14, pp.202~209 (2009)
- Berwick RC, "Evolution, brain, and the nature of language", Trends Cogn Sci, 17, pp.89~98 (2013)
- Gray T, "The relationship between language control and cognitive control in bilingual aphasia", Biling(Camb Engl), 19, pp.433~452 (2016)
- Perlovsky L, "Language and cognition", Neural Netw, 22, pp.247~257 (2009)
- 한민정, "Effects of Antiepileptic Drugs on Language Abilities in Benign Epilepsy of Childhood with Centrotemporal Spikes", Journal of Clinical Neurology, 14(4), pp.523~529 (2018), 대한신경과학회[DOI]
- Riney K, "International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age : position statement by the ILAE task force on nosology and definitions", Epilepsia, 63, pp.1443~1474 (2022)
- Kwang Min Choi, "Correlations Between Values of Articulation Tests and Language Tests for Children With Articulation Disorder in Korea", Annals of Rehabilitation Medicine, 43(4), pp.483~489 (2019), 대한재활의학회[DOI]
- Bae SY, "Test of Problem Solving", Community Rehabilitation Center, ~ (2005)
- Kim YT, "Korean Version of Peabody-Picture Vocabulary Test", Community Rehabilitation Center, ~ (1995)
- Price LH, "Incorporating computer-aided language sample analysis into clinical practice", Lang Speech Hear Serv Sch, 41, pp.206~222 (2010)
- Rice ML, "Mean length of utterance in children with specific language impairment and in younger control children shows concurrent validity and stable and parallel growth trajectories", J Speech Lang Hear Res, 49, pp.793~808 (2006)
- Kwan P, "Effectiveness of first antiepileptic drug", Epilepsia, 42, pp.1255~1260 (2001)
- McCabe PC, "The relationship between language and social competence : how language impairment affects social growth", Psychol Sch, 41, pp.313~321 (2004)
- Nevile M, "The embodied turn in research on language and social interaction", Res Lang Soc Interact, 48, pp.121~151 (2015)
- Kim SY, "Cognitive effects of lowdose topiramate compared with oxcarbazepine in epilepsy patients", J Clin Neurol, 2, pp.126~133 (2006)
- 서종근, "Comparison of Cognitive Effects of Lamotrigine and Oxcarbazepine in Epilepsy Patients", Journal of Clinical Neurology, 3(1), pp.31~37 (2007), 대한신경과학회
- Thelengana A, "Cognitive, behavioural and sleep-related adverse effects on introduction of levetiracetam versus oxcarbazepine for epilepsy", Epilepsy Res, 150, pp.58~65 (2019)
- Kim D, "Cognitive and psychosocial effects of oxcarbazepine monotherapy in newly diagnosed partial epilepsy", Clin Neuropharmacol, 37, pp.100~107 (2014)
- Eun SH, "A multicenter trial of oxcarbazepine oral suspension monotherapy in children newly diagnosed with partial seizures : a clinical and cognitive evaluation", Seizure, 21, pp.679~684 (2012)
- Chen J, "Long-term antiepileptic drug administration during early life inhibits hippocampal neurogenesis in the developing brain", J Neurosci Res, 87, pp.2898~2907 (2009)