兩義供辰丹을 倂用한 한방치료가 重症度의 통증 환자에 미치는 진통 효과 : 후향적 연구
Analgesic Effect of a Traditional Korean Medicine Yang Eui Gongjin-dan on Severe Pain: A Retrospective Study
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Objectives: The aim of this study was to investigate the analgesic effect of Yang Eui Gongjin-dan (YEGJD), a traditional Korean medicine, on severe pain or numbness, including acute and chronic non-cancer pain. Methods: Records of patients visiting the Department of Traditional Korean Internal Medicine, Stroke and Neurological Disorders Center, from March 2011 to January 2015, were searched. Their chief complaint was severe numbness or pain (NRS≥7). We compared the NRS of pain pre- and post-YEGJD treatment in 34 patients; and analyzed changes in pain severity pre- and post-YEGJD treatment in 17 chronic non-cancer pain patients. We also investigated other accompanying symptoms, such as insomnia, anorexia, dyspepsia, fatigue, coldness, and excessive sweating, related to the deficiency state (虛症) in traditional Korean medicine. Results: The average pain NRS for the 34 patients significantly decreased from 8.04±1.08 to 3.75±2.54 after YEGJD treatment. The average pain NRS score in chronic non-cancer pain patients also significantly declined from 7.91±0.97 to 3.29±2.29. Conclusions: The traditional Korean medicine Yang Eui Gongjin-dan has an analgesic effect and is useful for treating severe pain or numbness. We recommend a randomized controlled trial using objective assessment scales and a large patient sample to further test the effects of Yang Eui Gongjin-dan.
Abstract
Objectives: The aim of this study was to investigate the analgesic effect of Yang Eui Gongjin-dan (YEGJD), a traditional Korean medicine, on severe pain or numbness, including acute and chronic non-cancer pain. Methods: Records of patients visiting the Department of Traditional Korean Internal Medicine, Stroke and Neurological Disorders Center, from March 2011 to January 2015, were searched. Their chief complaint was severe numbness or pain (NRS≥7). We compared the NRS of pain pre- and post-YEGJD treatment in 34 patients; and analyzed changes in pain severity pre- and post-YEGJD treatment in 17 chronic non-cancer pain patients. We also investigated other accompanying symptoms, such as insomnia, anorexia, dyspepsia, fatigue, coldness, and excessive sweating, related to the deficiency state (虛症) in traditional Korean medicine. Results: The average pain NRS for the 34 patients significantly decreased from 8.04±1.08 to 3.75±2.54 after YEGJD treatment. The average pain NRS score in chronic non-cancer pain patients also significantly declined from 7.91±0.97 to 3.29±2.29. Conclusions: The traditional Korean medicine Yang Eui Gongjin-dan has an analgesic effect and is useful for treating severe pain or numbness. We recommend a randomized controlled trial using objective assessment scales and a large patient sample to further test the effects of Yang Eui Gongjin-dan.
참고문헌 (28)
- Bennett M, "The LANSS Pain Scale: the Leeds assessment of neuropathic symptoms and signs", Pain, 92, pp.147~157 (2001)
- Trescot AM, "Opioids in the management of chronic non-cancer pain: an update of American Society of interventional Pain Physicians'(ASIPP) guidelines", Pain Physician, 11, pp.S5~S62 (2008)
- 남언정, "만성 통증을 호소하는 환자의 치료와 접근방법", 대한내과학회지, 73(2), pp.S794~S805 (2007)
- 윤덕미, "질병의 특성에 따른 진통제의 선택", 대한의사협회지, 54(7), pp.739~746 (2011), 대한의사협회
- 이재수, "내경의 원리를 기반으로 한 비증에 대한연구", 제한동의학술원, 20(3), pp.83~92 (1995)
- 위역림, "세의득효방", pp.271~ (1990), 인민위생출판사
- 황도연, "신증 방약합편", pp.142~ (2002), 영림사
- 박치상, "拱辰丹의 성분 분석 및 抗酸化 작용에 미치는 영향", 대한본초학회지, 22(2), pp.51~63 (2007), 대한본초학회
- 김홍준, "마우스 복강대식세포에서 加減拱辰丹의 항염증 효과", 대한한의학 방제학회지, 19(1), pp.207~217 (2011), 대한한의학방제학회
- Hong SS, "The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model", J Ethnopharmacol, 168, pp.268~278 (2015)
- Moon E, "The multi-herbal medicine Gongjin-dan enhances memory and learning tasks via NEG regulation", Neurosci Lett, (9), pp.114~119 (2009)
- 정효창, "공진단이 알츠하이머형 치매 환자에게 미치는 영향", 동의신경정신과학회지, 15(2), pp.141~148 (2004), 대한한방신경정신과학회
- 김민경, "중등도의 寒痺證을 주소로 내원한 환자에게 兩儀供辰丹을 투여하여 호전된 4례 : 증례보고", 대한한방내과 학술대회지, pp.312~318 (2012)
- 한국 한의학연구원 침구경락연구센터, "침의 서양의학적 접근과 임상", pp.41~47 (2010), Elsevier Korea
- Pain Intensity Instruments, , National Institutes of Health-Warren Grant Magnuson Clinical Center, ~ (2003)
- 강윤규, "근골격계 만성 통증의 평가와 치료", Korean Journal of Family Medicine, 24(2), pp.1~111 (2003), 대한가정의학회
- 2011년 환자 1060명 대상 설문조사, "대한통증학회", ~
- 권태동, "급⋅만성 통증의 관리", 대한내과학회추계학술대회, pp.96~100 (2011)
- 전국한의과대학 심계내과학교실, "한방순환신경내과학", pp.416~423 (2011), 군자출판사
- 김상수, "비증에 대한 동서의학적 고찰(원인, 증상을위주로)", 대한한방내과학회지, 15(1), pp.116~127 (1994)
- 김명욱, "20세기 중의사들의 비증에 대한논술 연구", 대전대학교 한의학연구소 논문집, 9(1), pp.547~594 (2000)
- 허준, "대역 동의보감", pp.1180~ (1999), 법인문화사
- 이규재, "사향에 대한 문헌적 고찰", Journal of Pharmacopuncture, 8(3), pp.71~77 (2005), 대한약침학회
- 허준, "대역 동의보감", pp.982~ (1999), 법인문화사
- 이보영, "사향이 생쥐의 뇌손상에 미치는 영향", 대한한의학회지, 16(2), pp.299~311 (1995)
- 류도균, "목향및 사향이 저산소증 유발 배양 대뇌신경세포에미치는 영향", 대한한방내과학회지, 24(2), pp.348~357 (2003)
- 임석린, "사향의 수용성분이 생쥐 복강내 거식세포의 활성에 미치는 영향", 대한예방한의학회지, 6(2), pp.147~155 (2002)
- 황성록, "牛黃淸心元이 당뇨병 Rat의 혈액순환장애에 미치는 영향", 대한한의학회지, 23(2), pp.352~367 (2002), 대한한의학회