파킨슨병 환자의 통증에 대한 한의치료의 효과 : 후향적 연구
Effects of Korean Medicine on Pain in Patients with Parkinson's Disease: A Retrospective Study
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Objectives: To investigate efficacy of Korean medicine for patients with Parkinson’s Disease (PD) with pain. Methods: We performed a retrospective review of the medical records for patients diagnosed with PD between 2012 and 2019 at Gangdong Kyung Hee University Korean Medicine Hospital in South Korea. Results: Twenty-two patients with King's Parkinson's Disease Pain Scale(KPPS) scores at least twice were analyzed for evaluating the efficacy of Korean medicine for pain treatment in PD. The mean total scores before and after Korean medicine treatment were 15.23±11.01 and 9.2±8.7, respectively, and the mean difference between the before/after total scores was 6.0±5.8 (P<0.001). Specifically, the score of radicular pain was significantly decreased (P=0.048). Conclusions: These findings suggest that Korean medicine could be beneficial for reducing pain associated with PD. Clinical efficacy should be confirmed by further studies, such as large-sample cohort studies and randomized controlled trials to clarify the pathological pain relief mechanism and the analgesic effect of Korean medicine.
Abstract
Objectives: To investigate efficacy of Korean medicine for patients with Parkinson’s Disease (PD) with pain. Methods: We performed a retrospective review of the medical records for patients diagnosed with PD between 2012 and 2019 at Gangdong Kyung Hee University Korean Medicine Hospital in South Korea. Results: Twenty-two patients with King's Parkinson's Disease Pain Scale(KPPS) scores at least twice were analyzed for evaluating the efficacy of Korean medicine for pain treatment in PD. The mean total scores before and after Korean medicine treatment were 15.23±11.01 and 9.2±8.7, respectively, and the mean difference between the before/after total scores was 6.0±5.8 (P<0.001). Specifically, the score of radicular pain was significantly decreased (P=0.048). Conclusions: These findings suggest that Korean medicine could be beneficial for reducing pain associated with PD. Clinical efficacy should be confirmed by further studies, such as large-sample cohort studies and randomized controlled trials to clarify the pathological pain relief mechanism and the analgesic effect of Korean medicine.
참고문헌 (37)
- Association of Korean Medicine Professors for Cardiovascular and Neurologic Medicine, "Cardiovascular and Neurological Medicine in Korean Medicine 3", pp.113~114 (2016), WOORI Medical Books
- Gelb DJ, "Diagnostic Criteria for Parkinson Disease", JAMA Neurol, 56(1), pp.33~39 (1999)
- Korean Longitudinal Study of Ageing(KLoSA), "Ministry of Employment and Labor", Korea Employment Information Service, ~ (2013)
- Nègre-Pages L, "DoPaMiP Study Group. Chronic pain in Parkinson's disease:the cross-sectional French DoPaMiP survey", Mov Disord, 23(10), pp.1361~1369 (2008)
- Perrotta A, "Facilitated temporal summation of pain at spinal level in Parkinson's disease", Mov Disord, 26(3), pp.442~448 (2011)
- Brefel-Courbon C, "Effect of levodopa on pain threshold in Parkinson's disease : a clinical and positron emission tomography study", Mov Disord, 20(12), pp.1557~1563 (2005)
- Tinazzi M, "Muscular pain in Parkinson's disease and nociceptive processing assessed with CO2 laser-evoked potentials", Mov Disord, 25(2), pp.213~220 (2010)
- Scherder E, "Pain in Parkinson's disease and multiple sclerosis : its relation to the medial and lateral pain systems", Neurosci Biobehav Rev, 29(7), pp.1047~1056 (2005)
- Broen MPG, "Prevalence of pain in Parkinson's disease : a systematic review using the modified QUADAS tool", Mov Disord, 27(4), pp.480~484 (2012)
- Ford B, "Pain in Parkinson's disease", Clin Neurosci, 5(2), pp.63~72 (1998)
- Chaudhuri KR, "King's Parkinson's disease pain scale, the first scale for pain in PD : An international validation", Mov Disord, 30(12), pp.1623~1631 (2015)
- Rukavina K, "Pain in Parkinson's disease : New concepts in pathogenesis and treatment", Curr Opin Neurol, 32(4), pp.579~588 (2019)
- Dellapina E, "Apomorphine effect on pain threshold in Parkinson's disease : a clinical and positron emission tomography study", Mov Disord, 26(1), pp.153~157 (2011)
- Trenkwalder C, "Prolonged-release oxycodone-naloxone for treatment of severe pain in patients with Parkinson's disease(PANDA) : A double-blind, randomised, placebo-controlled trial", Lancet Neurol, 14(12), pp.1161~1170 (2015)
- Mills R, "An Update on the Use of Botulinum Toxin Therapy in Parkinson's Disease", Current Neurology and Neuroscience Reports, 15(1), pp.1~11 (2015)
- Ondo WG, "Predictors of battery life for the Activa Soletra 7426 Neurostimulator", Parkinsonism Relat Disord, 13(4), pp.240~242 (2007)
- Anderson KO, "Rheumatoid Arthritis : Review of Psychological Factors Related to Etiology, Effects and Treatment", Psychological Bulletin, 98(2), pp.358~387 (1985)
- Jankovic J, "Variable expression of Parkinson's disease : A base-line analysis of the DAT ATOP cohort", Neurology, 40(10), pp.1529~1534 (1990)
- 정혜선, "한방병원에 내원한 파킨슨병 환자의 통증의 임상적 특성에 관한 후향적 의무기록 분석 연구", 대한한의학회지, 41(2), pp.23~33 (2020), 대한한의학회[DOI]
- Fil A, "Pain in Parkinson disease : A review of the literature", Parkinsonism and Related Disorders, 19(3), pp.285~294 (2013)
- Kanda T, "Changes of unmyelinated nerve fibers in sural nerve in amyotrophic lateral sclerosis, Parkinson's disease and multiple system atrophy", Acta Neuropathologica, 91(2), pp.145~154 (1996)
- Reichling DB, "Pain and death : Neurodegenerative disease mechanisms in the nociceptor", Annals of Neurology, 69(1), pp.13~21 (2011)
- Nolano M, "Sensory deficit in Parkinson's disease:Evidence of a cutaneous denervation", Brain, 131, pp.1903~1911 (2008)
- Mayela RV, "Clinical Determinants of Parkinson's Disease-associated Pain Using the King's Parkinson's Disease Pain Scale", Mov Disord Clin Pract, 4(4), pp.545~551 (2017)
- Duvoisin RC, "Note on the scoliosis of Parkinsonism", J Neurol Neurosurg Psychiatry, 38(8), pp.787~793 (1975)
- Zella MAS, "Landscape of pain in Parkinson's disease : impact of gender differences", Neurol Res, 41(1), pp.87~97 (2019)
- Chae Y, "Inserting needles into the body : a meta-analysis of brain activity associated with acupuncture needle stimulation", J Pain, 14(3), pp.215~222 (2013)
- Goldman N, "Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture", Nat Neurosci, 13(7), pp.883~888 (2010)
- Kim SN, "Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease", PLoS One, 6(11), pp.e27566~ (2011)
- Jang JH, "Acupuncture alleviates chronic pain and comorbid conditions in a mouse model of neuropathic pain:the involvement of DNA methylation in the prefrontal cortex", Pain (2020)[DOI]
- Alvarez-Fischer D, "Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model", PLoS One, 8(4), pp.e61700~ (2013)
- Li D, "Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain", Toxins (Basel), 7(7), pp.2422~2434 (2015)
- Kang SY, "Repetitive treatment with diluted bee venom reduces neuropathic pain via potentiation of locus coeruleus noradrenergic neuronal activity and modulation of spinal NR1 phosphorylation in rats", J Pain, 13(2), pp.155~166 (2012)
- 윤정원, "중성어혈약침 치료에 대한 임상논문 고찰 - 국내학술지를 중심으로", 한방재활의학과학회지, 27(4), pp.75~84 (2017), 한방재활의학과학회
- 정문재, "烏藥順氣散 및 中性瘀血 藥鍼이 흰쥐 좌골신경 압좌 손상 후 통증 감소와 신경 재생에 미치는 영향", 한방재활의학과학회지, 19(2), pp.51~72 (2009), 한방재활의학과학회
- 이성환, "腰脚痛에 대한 單鍼治療群, 蜂藥鍼 竝行治療群, 中性瘀血藥鍼 竝行治療群의 비교연구", Journal of Acupuncture Research, 24(5), pp.197~205 (2007), 대한침구의학회
- Yoon IJ, "Effect of Jungsongouhyul Herbal Acupuncture Therapy for Neck Pain Patients", Journal of Institute of Oriental Medicine Daejeon University, 16(2), pp.1~5 (2007)
