Effects of Acetaminophen on Reproductive Activities in Male Golden Hamsters
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Acetaminophen [Paracetamol, N-acetyl-para-aminophenol (APAP)] is a common over-thecounter analgesic agent as nonsteroidal anti-inflammatory drugs (NSAIDs). The high doses or the long-term treatment of acetaminophen via usual gavage feeding resulted in damage of testicles that presented recoverable impairment, as well as liver and kidney. The influence of acetaminophen was examined in male golden hamsters treated with acetaminophencontaining diet feeding. They were divided into 5 groups and subjected to this experiment for 4 weeks: animals housed in long photoperiod (LP) as LP control, animals housed in short photoperiod (SP) for 4 weeks as SP control (SP4), and groups of animals treated with low, middle, and high concentrations of acetaminophen (Low, Middle, High groups). Also animals housed in SP for 8 weeks were included (SP8) to contrast testicular activities, if necessary. As results, spermatozoa filled the seminiferous tubules of the testicles of animals in LP control and SP4 groups. The aspects were seen in the animals taken diets of low and middle doses of acetaminophen. The animals who fed high dose of acetaminophen showed large or small testicles. The large testicles displayed all germ cells at the steps of spermatogenesis. The small testicles presented no sperm as the animals housed in SP for 8 weeks. Thus these results indicate that acetaminophen invokes the antigonadal effects and accelerates the regressing process of the testicles in the animals compared to the animals exposed to SP.
Abstract
Acetaminophen [Paracetamol, N-acetyl-para-aminophenol (APAP)] is a common over-thecounter analgesic agent as nonsteroidal anti-inflammatory drugs (NSAIDs). The high doses or the long-term treatment of acetaminophen via usual gavage feeding resulted in damage of testicles that presented recoverable impairment, as well as liver and kidney. The influence of acetaminophen was examined in male golden hamsters treated with acetaminophencontaining diet feeding. They were divided into 5 groups and subjected to this experiment for 4 weeks: animals housed in long photoperiod (LP) as LP control, animals housed in short photoperiod (SP) for 4 weeks as SP control (SP4), and groups of animals treated with low, middle, and high concentrations of acetaminophen (Low, Middle, High groups). Also animals housed in SP for 8 weeks were included (SP8) to contrast testicular activities, if necessary. As results, spermatozoa filled the seminiferous tubules of the testicles of animals in LP control and SP4 groups. The aspects were seen in the animals taken diets of low and middle doses of acetaminophen. The animals who fed high dose of acetaminophen showed large or small testicles. The large testicles displayed all germ cells at the steps of spermatogenesis. The small testicles presented no sperm as the animals housed in SP for 8 weeks. Thus these results indicate that acetaminophen invokes the antigonadal effects and accelerates the regressing process of the testicles in the animals compared to the animals exposed to SP.
참고문헌 (34)
- Aksu EH, "Mitigation of paracetamol-induced reproductive damage by chrysin in male rats via reducing oxidative stress", Andrologia, 48, pp.1145~1154 (2016)
- Banihani SA, "Effect of paracetamol on semen quality", Andrologia, 50, pp.e12874~ (2018)
- Boizet-Bonhoure B, "Using experimental models to decipher the effects of acetaminophen and NSAIDs on reproductive development and health", Front Toxicol, 4, pp.835360~ (2022)
- Boyer TD, "Acetaminophen-induced hepatic necrosis and renal failure", JAMA, 218, pp.440~441 (1971)
- Chilvery S, "Acetaminophen induced hepatotoxicity: An overview of the promising protective effects of natural products and herbal formulations", Phytomedicine, 108, pp.154510~ (2023)
- 최돈찬, "Potency of Melatonin in Living Beings", 발생과 생식, 17(3), pp.149~177 (2013), 한국발생생물학회
- 최돈찬, "Effects of Dietary Supplement Containing Melatonin on Reproductive Activity in Male Golden Hamsters", 발생과 생식, 23(2), pp.101~110 (2019), 한국발생생물학회
- 최돈찬, "Neuroendocrine System in Seasonal Breeder: Focusing on the Reproductive Activity of Male Golden Hamster", 발생과 생식, 16(1), pp.1~8 (2012), 한국발생생물학회[DOI]
- Davidson DG, "Acute liver necrosis following overdose of paracetamol", Br Med J, 2, pp.497~499 (1966)
- de Kretser DM, "Spermatogenesis", Hum Reprod, 13, pp.1~8 (1998)
- Du K, "Oxidative stress during acetaminophen hepatotoxicity:Sources, pathophysiological role and therapeutic potential", Redox Biol, 10, pp.148~156 (2016)
- Elliott JA, "Circadian rhythms and photoperiodic time measurement in mammals", Fed Proc, 35, pp.2339~2346 (1976)
- Gaston S, "Photoperiodic control of hamster testis", Science, 158, pp.925~928 (1967)
- Geon Hyung Jeon, "The Effects of Daily Melatonin Gavage on Reproductive Activity in the Male Syrian Hamsters", 발생과 생식, 24(4), pp.263~275 (2020), 한국발생생물학회
- Jóźwiak-Bebenista M, "Paracetamol: Mechanism of action, applications and safety concern", Acta Pol Pharm, 71, pp.11~23 (2014)
- Khayyat LI, "Extra virgin olive oil protects the testis and blood from the toxicity of paracetamol (overdose) in adult male rats", Biology, 10, pp.1042~ (2021)
- Kristensen DM, "Analgesic use — prevalence, biomonitoring and endocrine and reproductive effects", Nat Rev Endocrinol, 12, pp.381~393 (2016)
- Lancaster EM, "Acetaminophen hepatotoxicity: An updated review", Arch Toxicol, 89, pp.193~199 (2015)
- 이지수, "The Effects of Cynomorium songaricum on the Reproductive Activity in Male Golden Hamsters", 발생과 생식, 17(1), pp.37~43 (2013), 한국발생생물학회
- Luangpirom A, "Attenuating effect of Allium ascalonicum L. on paracetamol induced seminal quality impairment in mice", J Med Plants Res, 6, pp.2655~2659 (2012)
- Mazer M, "Acetaminophen-induced nephrotoxicity: Pathophysiology, clinical manifestations, and management", J Med Toxicol, 4, pp.2~6 (2008)
- "History of tylenol" (2014)[URL]
- Olaleye MT, "Acetaminophen induced liver damage in mice: Effect of some medicinal plants on the oxidative defense system", Exp Toxicol Pathol, 59, pp.319~327 (2008)
- Oyedeji KO, "Effect of paracetamol (acetaminophen) on haematological and reproductive parameters in male albino rats", IOSR J Pharm Biol Sci, 4, pp.65~70 (2013)
- Rahimi O, "Hepatorenal protective effects of hydroalcoholic extract of Solidago canadensis L. against paracetamol-induced toxicity in mice", J Toxicol, 2022, pp.9091605~ (2022)
- Ratnasooriya WD, "Long-term administration of large doses of paracetamol impairs the reproductive competence of male rats", Asian J Androl, 2, pp.247~255 (2000)
- Reel JR, "Reproductive toxicity evaluation of acetaminophen in Swiss CD-1 mice using a continuous breeding protocol", Fundam Appl Toxicol, 18, pp.233~239 (1992)
- Reiter RJ, "The pineal and its hormones in the control of reproduction in mammals", Endocr Rev, 1, pp.109~131 (1980)
- Seco-Rovira V, "Testicular histomorphometry and the proliferative and apoptotic activities of the seminiferous epithelium in Syrian hamster (Mesocricetus auratus) during regression owing to short photoperiod", Andrology, 3, pp.598~610 (2015)
- Sinha Hikim AP, "Morphometric studies on hamster testes in gonadally active and inactive states: Light microscope findings", Biol Reprod, 39, pp.1225~1237 (1988)
- Stetson MH, "The Pineal Gland", pp.109~153 (1984), Raven Press
- Stetson MH, "Effects of exogenous and endogenous melatonin on gonadal function in hamsters", J Neural Transm, 21, pp.55~80 (1986)
- Tadokoro-Cuccaro R, "Maternal paracetamol intake during pregnancy—impacts on offspring reproductive development", Front Toxicol, 4, pp.884704~ (2022)
- Watson-Whitmyre M, "A mathematical method for estimating paired testes weight from in situ testicular measurements in three species of hamster", Anat Rec, 213, pp.473~476 (1985)