유방암의 악성도에 따른 스테로이드호르몬 수용체와 종양단백질의 발현과의 상관성

Abstract

This study was designed to compare and analyze the overall relationship between independent factors inducing breast cancer, the steroid hormone receptors(ER and PR), and oncoproteins(C-erbB-2, P-53 and Bcl-2). A total of 21 test samples underwent tissue studies with H&E staining to test histologic grading. ER, PR, P-53, C-erbB-2, Bcl-2, and Ki 67 were examined with immunohistochemistry. Although ER and PR showed no statistically significant difference in histologic grade, the induction of PR increased when induction of ER increased showing a significant relationship(P<0.05). C-erbB-2 oncoprotein showed no statistically significant relationship with histologic grade, nuclei mitosis index, lymphnode metastasis, menopause, and P-53 oncoprotein, whereas it showed a statistically significant relationship with PR, ER, and Bcl-2 oncoproteins(P<0.05). P-53 oncoprotein showed no statistically significant relationship with C-erbB-2 oncoprotein, histologic grade, lymphnode metastasis, and menopause, whereas it showed statistically significant relationships with ER, PR, Bcl-2, and nuclei mitosis index(P<0.05). Bcl-2 oncoprotein showed no statistically significant relationship with lymphnode metastasis, histologic grade, and menopause, whereas it showed statistically significant relationships with other pathological prognosis factors(ER, PR, P-53, C-erbB-2 and nuclei mitosis index)(P<0.05). In conclusion, ER, PR, and oncoproteins(C-erbB-2, P-53 and Bcl-2) showed no significant difference with histologic grade. However ER, PR, and oncoproteins showed significant relationships with each other. The induction rate of P-53 oncoprotein was low when that of Bcl-2 oncoprotein was high while Bcl-2 oncoprotein and P-53 oncoprotein showed a reciprocal relationship with each other.