Proton pump inhibitor intake negatively affects the osseointegration of dental implants: a retrospective study
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Objectives: This study sought to investigate the association between the systemic intake of proton pump inhibitors (PPI) and the early failure of dental implants. Materials and Methods: A retrospective cohort study involving 1,918 dental implants in 592 patients (69 implants in 24 PPI users and 1,849 implants in 568 nonusers, respectively) was conducted. The effect of PPI intake on the osseointegration of dental implants was evaluated using patient- and implant-level models. Results: Among 24 PPI users, two patients experienced implant failure, one of whom had three and the other of whom had one failed implant, respectively. Thus, the rate of failure for this population was 8.3%. Separately, 11 nonusers each experienced one implant failure, and the failure rate for these patients was 1.9%. Fisher’s exact test revealed statistically significant differences between PPI users and nonusers at the implant level (P=0.002) but failed to show any significance at the patient level (P=0.094). The odds of implant failure were 4.60 times greater among PPI users versus nonusers. Dental implants that were placed in patients using PPIs were found to be 4.30 times more likely to fail prior to loading. Conclusion: The findings of this study suggest that PPI intake may be associated with an increased risk of early dental implant failure.
Abstract
Objectives: This study sought to investigate the association between the systemic intake of proton pump inhibitors (PPI) and the early failure of dental implants. Materials and Methods: A retrospective cohort study involving 1,918 dental implants in 592 patients (69 implants in 24 PPI users and 1,849 implants in 568 nonusers, respectively) was conducted. The effect of PPI intake on the osseointegration of dental implants was evaluated using patient- and implant-level models. Results: Among 24 PPI users, two patients experienced implant failure, one of whom had three and the other of whom had one failed implant, respectively. Thus, the rate of failure for this population was 8.3%. Separately, 11 nonusers each experienced one implant failure, and the failure rate for these patients was 1.9%. Fisher’s exact test revealed statistically significant differences between PPI users and nonusers at the implant level (P=0.002) but failed to show any significance at the patient level (P=0.094). The odds of implant failure were 4.60 times greater among PPI users versus nonusers. Dental implants that were placed in patients using PPIs were found to be 4.30 times more likely to fail prior to loading. Conclusion: The findings of this study suggest that PPI intake may be associated with an increased risk of early dental implant failure.
참고문헌 (30)
- Mangano F, "Is low serum vitamin D associated with early dental implant failure? A retrospective evaluation on 1625 implants placed in 822 patients", Mediators Inflamm, 2016, pp.5319718~ (2016)
- Chrcanovic BR, "Factors influencing early dental implant failures", J Dent Res, 95, pp.995~1002 (2016)
- Olmedo-Gaya MV, "Risk factors associated with early implant failure : a 5-year retrospective clinical study", J Prosthet Dent, 115, pp.150~155 (2016)
- Koldsland OC, "Prevalence of implant loss and the influence of associated factors", J Periodontol, 80, pp.1069~1075 (2009)
- Jemt T, "Incidence of first implant failure: a retroprospective study of 27 years of implant operations at one specialist clinic", Clin Implant Dent Relat Res, 17(Suppl 2), pp.e501~e510 (2015)
- Berglundh T, "A systematic review of the incidence of biological and technical complications in implant dentistry reported in prospective longitudinal studies of at least 5 years", J Clin Periodontol, 29(Suppl 3), pp.197~212 (2002)
- Charyeva O, "Longterm dental implant success and survival--a clinical study after an observation period up to 6 years", Swed Dent J, 36, pp.1~6 (2012)
- Albrektsson T, "Osseointegrated titanium implants. Requirements for ensuring a longlasting, direct bone-to-implant anchorage in man", Acta Orthop Scand, 52, pp.155~170 (1981)
- Trindade R, "Current concepts for the biological basis of dental implants : foreign body equilibrium and osseointegration dynamics", Oral Maxillofac Surg Clin North Am, 27, pp.175~183 (2015)
- Mangano C, "Morse taper connection implants supporting"planned"maxillary and mandibular bar-retained overdentures : a 5-year prospective multicenter study", Clin Oral Implants Res, 22, pp.1117~1124 (2011)
- Apostu D, "Systemic drugs that influence titanium implant osseointegration", Drug Metab Rev, 49, pp.92~104 (2017)
- Kellesarian SV, "Role of local alendronate delivery on the osseointegration of implants : a systematic review and metaanalysis", Int J Oral Maxillofac Surg, 46, pp.912~921 (2017)
- Wu X, "Antihypertensive medications and the survival rate of osseointegrated dental implants : a cohort study", Clin Implant Dent Relat Res, 18, pp.1171~1182 (2016)
- Wu X, "Selective serotonin reuptake inhibitors and the risk of osseointegrated implant failure : a cohort study", J Dent Res, 93, pp.1054~1061 (2014)
- Al Subaie A, "Systemic administration of omeprazole interferes with bone healing and implant osseointegration : an in vivo study on rat tibiae", J Clin Periodontol, 43, pp.193~203 (2016)
- Chrcanovic BR, "Intake of proton pump inhibitors is associated with an increased risk of dental implant failure", Int J Oral Maxillofac Implants, 32, pp.1097~1102 (2017)
- Wu X, "Proton pump inhibitors and the risk of osseointegrated dental implant failure : a cohort study", Clin Implant Dent Relat Res, 19, pp.222~232 (2017)
- Leontiadis GI, "Proton pump inhibitors and risk of bone fractures", Curr Treat Options Gastroenterol, 12, pp.414~423 (2014)
- Stedman CA, "Review article : comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors", Aliment Pharmacol Ther, 14, pp.963~978 (2000)
- Freedberg DE, "The risks and benefits of longterm use of proton pump inhibitors : expert review and best practice advice from the American Gastroenterological Association", Gastroenterology, 152, pp.706~715 (2017)
- Abraham NS, "Proton pump inhibitors : potential adverse effects", Curr Opin Gastroenterol, 28, pp.615~620 (2012)
- Yang YX, "Long-term proton pump inhibitor therapy and risk of hip fracture", JAMA, 296, pp.2947~2953 (2006)
- Costa-Rodrigues J, "Dose-dependent inhibitory effects of proton pump inhibitors on human osteoclastic and osteoblastic cell activity", FEBS J, 280, pp.5052~5064 (2013)
- Dobrowolski P, "Can 2-oxoglutarate prevent changes in bone evoked by omeprazole", Nutrition, 29, pp.556~561 (2013)
- Devlin JW, "Proton pump inhibitor formulary considerations in the acutely ill. Part 2: clinical efficacy, safety, and economics", Ann Pharmacother, 39, pp.1844~1851 (2005)
- Yu LY, "A review of the novel application and potential adverse effects of proton pump inhibitors", Adv Ther, 34, pp.1070~1086 (2017)
- Serfaty-Lacrosniere C, "Hypochlorhydria from short-term omeprazole treatment does not inhibit intestinal absorption of calcium, phosphorus, magnesium or zinc from food in humans", J Am Coll Nutr, 14, pp.364~368 (1995)
- Boyce BF, "Stomaching calcium for bone health", Nat Med, 15, pp.610~612 (2009)
- Lau YT, "Fracture risk and bone mineral density reduction associated with proton pump inhibitors", Pharmacotherapy, 32, pp.67~79 (2012)
- Gunasekaran TS, "Efficacy and safety of omeprazole for severe gastroesophageal reflux in children", J Pediatr, 123, pp.148~154 (1993)